Abstract
The mixed dissociation constant of naphazoline is determined at various ionic strengths I [mol dm−3] in the range of 0.01 to 0.26 and at temperatures of 25°C and 37°C using ESAB and HYPERQUAD regression analysis of the potentiometric titration data. A strategy of efficient experimentation is proposed in a protonation constant determination, followed by a computational strategy for the chemical model with a protonation constant determination. Two group parameters, L 0 and H T were ill-conditioned in the model and their determination is therefore uncertain. These group parameters, L 0 and H T, can significantly influence a systematic error in the estimated common parameter pKa and they always should be refined together with pK a. The thermodynamic dissociation constant pK Ta was estimated by nonlinear regression of {pK a, I} data at 25°C and 37°C: for naphazoline pK Tal = 10.41(1) and 10.13(2). Goodness-of-fit tests for various regression diagnostics enabled the reliability of the parameter estimates to be found.
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Meloun, M., Ferenčíková, Z., Netolická, L. et al. The thermodynamic dissociation constant of naphazoline by the regression analysis of potentiometric data. cent.eur.j.chem. 9, 66–74 (2011). https://doi.org/10.2478/s11532-010-0117-9
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DOI: https://doi.org/10.2478/s11532-010-0117-9