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Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative

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Central European Journal of Chemistry

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Abstract

This paper presents the synthesis of complex compounds of type [M(L1)2], where M(II)= Cu (1), Co (2), Zn (3), L1=2-aminothiazole-4-acetate and [Mn(L1)2(H2O)] (4) using ethyl 2-(2-aminothiazole-4-yl) acetate (L), and characterization by elemental analysis, magnetic susceptibilities, IR, 1H-NMR, UV-Vis spectroscopy and for [Mn(L1)2(H2O)] also by X-ray diffraction. In vitro cytotoxicity studies were performed on human cervix adenocarcinoma, HeLa cells. The antitumor selectivity was assessed using normal human peripheral blood mononuclear cells, PBMC as control.

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Authors and Affiliations

  1. Inorganic Chemistry Department, University “Politehnica” of Bucharest, 011061, Bucharest, Romania

    Maria-Gabriela Alexandru & Ioana Jitaru

  2. Department of Biochemistry, University of Belgrade, Faculty of Chemistry, 11000, Belgrade, Serbia

    Tanja Cirkovic Velickovic

  3. Faculty of Chemistry, Department of Inorganic Chemistry, University of Belgrade, 11000, Belgrade, Serbia

    Sanja Grguric-Sipka

  4. C.D. Nenitescu Center of Organic Chemistry of the Romanian Academy, 71141, Bucharest, Romania

    Constantin Draghici

Authors
  1. Maria-Gabriela Alexandru
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  2. Tanja Cirkovic Velickovic
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  3. Ioana Jitaru
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  4. Sanja Grguric-Sipka
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  5. Constantin Draghici
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Correspondence to Maria-Gabriela Alexandru.

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Alexandru, MG., Velickovic, T.C., Jitaru, I. et al. Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative. cent.eur.j.chem. 8, 639–645 (2010). https://doi.org/10.2478/s11532-010-0022-2

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  • DOI: https://doi.org/10.2478/s11532-010-0022-2

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