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Synthesis and pharmacological properties of 3-(2-methyl-furan-3-yl)-4-substituted-Δ2-1,2,4-triazoline-5-thiones

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Central European Journal of Chemistry

Abstract

By the reaction of 2-methyl-furan-3-carboxylic acid hydrazide with isothiocyanates, 1-[(2-methyl-furan-3-yl)carbonyl]-4-substituted thiosemicarbazides 1 were obtained. Further cyclization with 2% NaOH led to the formation of 3-(2-methyl-furan-3-yl)-4-substituted-Δ2-1,2,4-triazoline-5-thiones 2. The pharmacological effects of 2 on the central nervous system in mice were investigated. Strong antinociceptive properties of the investigated derivatives were observed in a wide range of doses.

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Authors and Affiliations

  1. Department of Organic Chemistry, Faculty of Pharmacy, Medical University, Staszica 6, 20-081, Lublin, Poland

    Agata Siwek, Monika Wujec & Maria Dobosz

  2. Department of Toxicology, Medical University, 20-093, Lublin, Poland

    Ewa Jagiełło-Wójtowicz, Anna Chodkowska & Agnieszka Kleinrok

  3. Department of Computer Science, Academy of Humanities and Economics in Lodz, 90-222, Lodz, Poland

    Piotr Paneth

Authors
  1. Agata Siwek
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  2. Monika Wujec
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  3. Maria Dobosz
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  4. Ewa Jagiełło-Wójtowicz
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  5. Anna Chodkowska
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  6. Agnieszka Kleinrok
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  7. Piotr Paneth
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Correspondence to Agata Siwek.

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Siwek, A., Wujec, M., Dobosz, M. et al. Synthesis and pharmacological properties of 3-(2-methyl-furan-3-yl)-4-substituted-Δ2-1,2,4-triazoline-5-thiones. cent.eur.j.chem. 6, 47–53 (2008). https://doi.org/10.2478/s11532-007-0058-0

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  • DOI: https://doi.org/10.2478/s11532-007-0058-0

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