Abstract
New substituted 2-[2-(4-nitrobenzoyl)hydrazinylidene]-4-oxobut-2-enoic acids have been synthesized by condensation of 4-nitrobenzohydrazide with 4-aryl-2,4-dioxobutanoic acids, and their intramolecular cyclization in the presence of propionic anhydride afforded the corresponding substituted 3-[2-(4-nitrobenzoyl)hydrazinylidene]furan-2(3H)-ones. The synthesized compounds were evaluated for their antinociceptive activity.
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This study was performed under financial support by the “Rational Use of the Earth Interior” Perm Scientific Educational Center, 2021.
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Translated from Zhurnal Organicheskoi Khimii, 2021, Vol. 57, No. 12, pp. 1736–1743 https://doi.org/10.31857/S0514749221120089.
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Denisova, E.I., Lipin, D.V., Parkhoma, K.Y. et al. Synthesis, Intramolecular Cyclization, and Antinociceptive Activity of Substituted 2-[2-(4-Nitrobenzoyl)hydrazinylidene]-4-oxobut-2-enoic Acids. Russ J Org Chem 57, 1955–1960 (2021). https://doi.org/10.1134/S1070428021120083
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DOI: https://doi.org/10.1134/S1070428021120083