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Treat myasthenia gravis with individualized doses of acetylcholinesterase inhibitors and immunomodulators

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Fig. 1
Table I

References

  1. Angelini C. Diagnosis and management of autoimmune myasthenia gravis. Clin Drug Investig 2011; 31(1): 1–14

    Article  PubMed  CAS  Google Scholar 

  2. Phillips 2nd LH, Torner JC. Epidemiologic evidence for a changing natural history of myasthenia gravis. Neurology 1996; 47(5): 1233–8

    Article  PubMed  Google Scholar 

  3. Drachman DB. Myasthenia gravis. N Engl J Med 1994 Jun 23; 330(25): 1797–810

    Article  PubMed  CAS  Google Scholar 

  4. Phillips 2nd LH. The epidemiology of myasthenia gravis. Ann N Y Acad Sci 2003 Sep; 998: 407–12

    Article  PubMed  Google Scholar 

  5. Aragones JM, Bolibar I, Bonfill X, et al. Myasthenia gravis: a higher than expected incidence in the elderly. Neurology 2003; 60(6): 1024–6

    Article  PubMed  CAS  Google Scholar 

  6. Thanvi BR, Lo TC. Update on myasthenia gravis. Postgrad Med J 2004; 80(950): 690–700

    Article  PubMed  CAS  Google Scholar 

  7. Ohta K, Shigemoto K, Kubo S, et al. MuSK antibodies in AChR Ab-seropositive MG vs AChR Ab-seronegative MG. Neurology 2004; 62(11): 2132–3

    Article  PubMed  CAS  Google Scholar 

  8. Benatar M. A systematic review of diagnostic studies in myasthenia gravis. Neuromuscul Disord 2006; 16(7): 459–67

    Article  PubMed  Google Scholar 

  9. Skeie GO, Apostolski S, Evoli A, et al. Guidelines for the treatment of autoimmune neuromuscular transmission disorders. Eur J Neurol 2006; 13(7): 691–9

    Article  PubMed  CAS  Google Scholar 

  10. Gronseth GS, Barohn RJ. Practice parameter: thymectomy for autoimmune myasthenia gravis (an evidence-based review). Neurology 2009; 55(1): 7–15

    Article  Google Scholar 

  11. Milner-Brown HS, Mellenthin M, Sharma ML, et al. Quantitative correlation between plasma pyridostigmine levels and neuromuscular function in myasthenia gravis. Neurology 1987; 37(5): 800–3

    Article  PubMed  CAS  Google Scholar 

  12. Pascuzzi RM, Coslett HB, Johns TR. Long-term corticosteroid treatment of myasthenia gravis: report of 116 patients. Ann Neurol 1984; 15(3): 291–8

    Article  PubMed  CAS  Google Scholar 

  13. Schneider-Gold C, Gajdos P, Toyka KV, et al. Corticosteroids for myasthenia gravis. Cochrane Database Syst Rev 2005; (2): CD002828

  14. Palace J, Newsom-Davis J, Lecky B. A randomized double-blind trial of prednisolone alone or with azathioprine in myasthenia gravis: Myasthenia Gravis Study Group. Neurology 1998; 50(6): 1778–83

    Article  PubMed  CAS  Google Scholar 

  15. Tindall RS, Rollins JA, Phillips JT, et al. Preliminary results of a double-blind, randomized, placebo-controlled trial of cyclosporine in myasthenia gravis. N Engl J Med 1987; 316(12): 719–24

    Article  PubMed  CAS  Google Scholar 

  16. Bonifati DM, Angelini C. Long-term cyclosporine treatment in a group of severe myasthenia gravis patients. J Neurol 1997; 244(9): 542–7

    Article  PubMed  CAS  Google Scholar 

  17. Hart IK, Sharshar T, Sathasivam S. Immunosuppressant drugs for myasthenia gravis. J Neurol Neurosurg Psychiatry 2009; 80(1): 5–6

    Article  PubMed  CAS  Google Scholar 

  18. Meriggioli MN, Ciafaloni E, Al-Hayk KA, et al. Mycophenolate mofetil for myasthenia gravis: an analysis of efficacy, safety, and tolerability. Neurology 2003; 61(10): 1438–40

    Article  PubMed  CAS  Google Scholar 

  19. Sanders DB, Hart IK, Mantegazza R, et al. An international, phase III, randomized trial of mycophenolate mofetil in myasthenia gravis. Neurology 2008; 71(6): 400–6

    Article  PubMed  CAS  Google Scholar 

  20. Muscle Study Group. A trial of mycophenolate mofetil with prednisone as initial immunotherapy in myasthenia gravis. Neurology 2008; 71(6): 394–9

    Article  Google Scholar 

  21. Hehir MK, Burns TM, Alpers JP, et al. Long-term experience with mycophenolate mofetil (MMF) in myasthenia gravis (MG): retrospective analysis of 103 patients [abstract]. Neurology 2009; 72(11 Suppl. 3): A440

    Google Scholar 

  22. Zinman L, Ng E, Bril V. IV immunoglobulin in patients with myasthenia gravis: a randomized controlled trial. Neurology 2007; 68(11): 837–41

    Article  PubMed  CAS  Google Scholar 

  23. Gajdos P, Chevret S, Toyka K. Plasma exchange for myasthenia gravis. Cochrane Database Syst Rev 2002; (4): CD002275

  24. Hart IK, Sathasivam S, Sharshar T. Immunosuppressive agents for myasthenia gravis. Cochrane Database Syst Rev 2007; (4): CD005224

  25. Gajdos P, Chevret S, Toyka K. Intravenous immunoglobulin for myasthenia gravis. Cochrane Database Syst Rev 2008; (1): CD002277

  26. Chan A, Lee DH, Linker R, et al. Rescue therapy with anti-CD20 treatment in neuroimmunologic breakthrough disease. J Neurol 2007; 254(11): 1604–6

    Article  PubMed  Google Scholar 

  27. Hain B, Jordan K, Deschauer M, et al. Successful treatment of MuSK antibody-positive myasthenia gravis with rituximab. Muscle Nerve 2006; 33(4): 575–80

    Article  PubMed  Google Scholar 

  28. Thakre M, Inshasi J, Marashi M. Rituximab in refractory MuSK antibody myasthenia gravis. J Neurol 2007; 254(7): 968–9

    Article  PubMed  Google Scholar 

  29. Sussman JD, Argov Z, McKee D, et al. Antisense treatment for myasthenia gravis: experience with monarsen. Ann N Y Acad Sci 2008; 1132: 283–90

    Article  PubMed  CAS  Google Scholar 

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Treat myasthenia gravis with individualized doses of acetylcholinesterase inhibitors and immunomodulators. Drugs Ther. Perspect 27, 18–21 (2011). https://doi.org/10.2165/11601680-000000000-00000

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