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Two Cases of Statin-Induced Rhabdomyolysis Associated with Mononeuropathy

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Abstract

HMG-CoA reductase inhibitors (statins) are highly effective drugs for prevention of cardiovascular events in high-risk patients. Due to the widespread prescription of these agents, special attention should be given to their rare adverse effects when these may have severe outcomes. Here, we report two cases of localized rhabdomyolysis associated with mononeuropathy in patients taking statins and suggest possible explanations for this uncommon association. Close monitoring for myopathic/neuropathic events is warranted in high-risk patients with pre-existing neuropathies who are taking statins.

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Acknowledgements

No funding was used to assist in the preparation of these case reports. The authors have no conflicts of interest that are directly relevant to the content of these reports.

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Authors and Affiliations

  1. Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy

    Gian Paolo Fadini, Cristina Crepaldi, Saula de Kreutzenberg, Antonio Tiengo & Angelo Avogaro

  2. Department of Medical and Surgical Sciences, University of Padova, Medical School, Padova, Italy

    Enzo Manzato

Authors
  1. Gian Paolo Fadini
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  2. Enzo Manzato
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  3. Cristina Crepaldi
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  4. Saula de Kreutzenberg
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  5. Antonio Tiengo
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  6. Angelo Avogaro
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Correspondence to Gian Paolo Fadini.

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Fadini, G.P., Manzato, E., Crepaldi, C. et al. Two Cases of Statin-Induced Rhabdomyolysis Associated with Mononeuropathy. Clin. Drug Investig. 30, 347–350 (2010). https://doi.org/10.2165/11535470-000000000-00000

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  • DOI: https://doi.org/10.2165/11535470-000000000-00000

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