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Uraemic pruritus: starting from scratch to relieve itch

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Table I

References

  1. Manenti L, Tansinda P, Vaglio, A. Uraemic pruritus: clinical characteristics, pathophysiology and treatment. Drugs 2009; 69(3): 251–63

    Article  PubMed  CAS  Google Scholar 

  2. Pisoni RL, Wikstrom B, Elder SJ, et al. Pruritus in haemodialysis patients: international results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant 2006; 21(12): 3495–505

    Article  PubMed  Google Scholar 

  3. Zucker I, Yosipovitch G, David M, et al. Prevalence and characterization of uremic pruritus in patients undergoing hemodialysis: uremic pruritus is still a major problem for patients with end-stage renal disease. J Am Acad Dermatol 2003; 49(5): 842–6

    Article  PubMed  Google Scholar 

  4. Carruthers SG, Larochelle P, Haynes RB, et al. Report of the Canadian Hypertension Society Consensus Conference. I. Introduction. CMAJ 1993; 149(3): 289–93

    PubMed  CAS  Google Scholar 

  5. Hiroshige K, Kabashima N, Takasugi M, et al. Optimal dialysis improves uremic pruritus. Am J Kidney Dis 1995; 25(3): 413–9

    Article  PubMed  CAS  Google Scholar 

  6. Kato A, Takita T, Furuhashi M, et al. Polymethylmethacrylate efficacy in reduction of renal itching in hemodialysis patients: crossover study and role of tumor necrosis factor-α. Artif Organs 2001; 25(6): 441–7

    Article  PubMed  CAS  Google Scholar 

  7. Lin HH, Liu YL, Liu JH, et al. Uremic pruritus, cytokines and polymethylmethacrilate artificial kidney. Artif Organs 2008; 32(6): 468–72

    Article  PubMed  CAS  Google Scholar 

  8. Aoike I. Clinical significance of protein adsorbable membranes: long-term clinical effects and analysis using a proteomic technique. Nephrol Dial Transplant 2007; 22Suppl. 5: 13–9

    Article  Google Scholar 

  9. Tarng DC, Cho YL, Liu HN, et al. Hemodialysis-related pruritus: a double-blind, placebo-controlled, crossover study of capsaicin 0.025% cream. Nephron 1996; 72(4): 617–22

    Article  PubMed  CAS  Google Scholar 

  10. Breneman DL, Cardone S, Blumsack RF, et al. Topical capsaicin for treatment of hemodialysis-related pruritus. J Am Acad Dermatol 1992; 26(1): 91–4

    Article  PubMed  CAS  Google Scholar 

  11. Weisshaar E, Dunker N, Gollnick H. Topical capsaicin therapy in humans with hemodialysis-related pruritus. Neurosci Lett 2003; 345(3): 192–4

    Article  PubMed  CAS  Google Scholar 

  12. Chen YC, Chiu WT, Wu MS. Therapeutic effect of topical gamma-linolenic acid on refractory uremic pruritus. Am J Kidney Dis 2006; 48(1): 69–76

    Article  PubMed  CAS  Google Scholar 

  13. Okada K, Matsumoto K. Effect of skin care with an emollient containing a high water content on mild uremic pruritus. Ther Apher Dial 2004; 8(5): 419–22

    Article  PubMed  Google Scholar 

  14. Morton CA, Lafferty M, Hau C, et al. Pruritus and skin hydration during dialysis. Nephrol Dial Transplant 1996; 11(10): 2031–6

    Article  PubMed  CAS  Google Scholar 

  15. Szepietowski JC, Reich A, Szepietowski T. Emollients with endo-cannabinoids in the treatment of uremic pruritus: discussion of the therapeutic options. Ther Apher Dial 2005; 9(3): 277–9

    Article  PubMed  Google Scholar 

  16. Kuypers DR, Claes K, Evenepoel P, et al. A prospective proof of concept study of the efficacy of tacrolimus ointment on uremic pruritus (UP) in patients on chronic dialysis therapy. Nephrol Dial Transplant 2004; 19(7): 1895–901

    Article  PubMed  CAS  Google Scholar 

  17. Duque MI, Yosipovitch G, Fleischer Jr AB, et al. Lack of efficacy of tacrolimus ointment 0.1% for treatment of hemodialysis-related pruritus: a randomized, double blind, vehicle-controlled study. J Am Acad Dermatol 2005; 52(3 Pt 1): 519–21

    Article  PubMed  Google Scholar 

  18. Che-Yi C, Wen CY, Min-Tsung K, et al. Acupuncture in haemodi-alysis patients at the Quchi (LI11) acupoint for refractory uraemic pruritus. Nephrol Dial Transplant 2005; 20(9): 1912–5

    Article  PubMed  Google Scholar 

  19. Gao H, Zhang W, Wang Y. Acupuncture treatment for 34 cases of uremic cutaneous pruritus. J Tradit Chin Med 2002; 22(1): 29–30

    PubMed  Google Scholar 

  20. Gilchrest BA, Rowe JW, Brown RS, et al. Relief of uremic pruritus with ultraviolet phototherapy. N Engl J Med 1977; 297(3): 136–8

    Article  PubMed  CAS  Google Scholar 

  21. Schultz BC, Roenigk HH. Uremic pruritus treated with ultraviolet light. JAMA 1980; 243(18): 1836–7

    Article  PubMed  CAS  Google Scholar 

  22. Seckin D, Demircay Z, Akin O. Generalized pruritus treated with narrowband UVB. Int J Dermatol 2007; 46(4): 367–70

    Article  PubMed  Google Scholar 

  23. De Marchi S, Cecchin E, Villalta D, et al. Relief of pruritus and decreases in plasma histamine concentrations during erythropoietin therapy in patients with uremia. N Engl J Med 1992; 326(15): 969–74

    Article  PubMed  Google Scholar 

  24. Gunal AI, Ozalp G, Yoldas TK, et al. Gabapentin therapy for pruritus in haemodialysis patients: a randomized, placebo-controlled, double-blind trial. Nephrol Dial Transplant 2004; 19(12): 3137–9

    Article  PubMed  CAS  Google Scholar 

  25. Naini AE, Harandi AA, Khanbabapour S, et al. Gabapentin: a promising drug for the treatment of uremic pruritus. Saudi J Kidney Dis Transpl 2007; 18(3): 378–81

    PubMed  Google Scholar 

  26. Manenti L, Vaglio A, Costantino E, et al. Gabapentin in the treatment of uremic itch: an index case and a pilot evaluation. J Nephrol 2005; 18(1): 86–91

    PubMed  CAS  Google Scholar 

  27. Russo GE, Spaziani M, Guidotti C, et al. Pruritus in chronic uremic patients in periodic hemodialysis: treatment with terfenadine (an antagonist of histamine H1 receptors) [in Italian]. Minerva Urol Nephrol 1986; 38(4): 443–7

    CAS  Google Scholar 

  28. Legroux-Crespel E, Cledes J, Misery L. A comparative study on the effects of naltrexone and loratadine on uremic pruritus. Dermatology 2004; 208(4): 326–30

    Article  PubMed  CAS  Google Scholar 

  29. Bousquet J, Rivory JP, Maheut M, et al. Double-blind placebo-controlled study of nicergoline in the treatment of pruritus in patients receiving maintenance hemodialysis. J Allergy Clin Immunol 1989; 83(4): 825–8

    Article  PubMed  CAS  Google Scholar 

  30. Pederson JA, Matter BJ, Czerwinski AW, et al. Relief of idiopathic generalized pruritus in dialysis patients treated with activated oral charcoal. Ann Intern Med 1980; 93(3): 446–8

    PubMed  CAS  Google Scholar 

  31. Giovannetti S, Bersotti G, Cupisti A, et al. Oral activated charcoal in patients with uremic pruritus. Nephron 1995; 70(2): 193–6

    Article  PubMed  CAS  Google Scholar 

  32. Peer G, Kivity S, Agami O. Randomized crossover trial of naltrexone in uremic pruritus. Lancet 1996; 348(9041): 1552–4

    Article  PubMed  CAS  Google Scholar 

  33. Wikstrom B, Geliert R, Ladefoged SD, et al. κ-Opioid system in uremic pruritus: multicenter, randomized, double-blind, placebo-controlled clinical studies. J Am Soc Nephrol 2005; 16(12): 3742–7

    Article  PubMed  Google Scholar 

  34. Balaskas EV, Bamihas GI, Karamouzis M, et al. Histamine and serotonine in uremic pruritus: effect of ondasetron in CAPD-pruritc patients. Nephron 1998; 78(4): 395–402

    Article  PubMed  CAS  Google Scholar 

  35. Ashmore SD, Jones CH, Newstead CG, et al. Ondasetron therapy for uremic pruritus in hemodialysis patients. Am J Kidney Dis 2000; 35(5): 827–31

    Article  PubMed  CAS  Google Scholar 

  36. Murphy M, Reaich D, Pai P, et al. A randomized, placebo-controlled, double-blind trial of ondasetron in renal itch. Br J Dermatol 2003; 148(2): 314–7

    Article  PubMed  CAS  Google Scholar 

  37. Layegh P, Mojahedi MJ, Malekshah PET, et al. Effect of oral granisetron in uremic pruritus. Indian J Dermatol Venereol Leprol 2007; 73(4): 231–4

    Article  PubMed  Google Scholar 

  38. Silva SR, Viana PC, Lugon NV, et al. Thalidomide for the treatment of uremic pruritus: a crossover randomized double-blind trial. Nephron 1994; 67(3): 270–3

    Article  PubMed  CAS  Google Scholar 

  39. Balaskas EV, Uldall RP. Erythropoietin treatment does not improve uremic pruritus. Perit Dial Int 1992; 12(3): 330–1

    PubMed  CAS  Google Scholar 

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Uraemic pruritus: starting from scratch to relieve itch. Drugs Ther. Perspect 25, 15–18 (2009). https://doi.org/10.2165/0042310-200925110-00004

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