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Febuxostat: a guide to its use in chronic hyperuricaemia

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References

  1. Hair PI, McCormack PL, Keating GM. Febuxostat. Drugs 2008; 68(13): 1865–74

    Article  PubMed  CAS  Google Scholar 

  2. European Medicines Agency. Adenuric (febuxostat): summary of product characteristics [online]. Available from URL: http://www.emea.europa.eu [Accessed 2008 Nov 7]

  3. Schlesinger N. Management of acute and chronic gouty arthritis: present state-of-the-art. Drugs 2004; 64(21): 2399–416

    Article  PubMed  CAS  Google Scholar 

  4. Wortmann RL, SchumacherJr HR. Monosodium urate deposition arthropathy part II: treatment and long-term management of patients with gout. Adv Studies Med 2005; 5(4): 183–94

    Google Scholar 

  5. Becker MA, SchumacherJr HR, Wortmann RL, et al. Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase: a twenty-eight-day, multicenter, phase II, randomized, double-blind, placebo-controlled, dose-response clinical trial examining safety and efficacy in patients with gout. Arthritis Rheum 2005 Mar; 52(3): 916–23

    Article  PubMed  CAS  Google Scholar 

  6. Becker MA, SchumacherJr HR, Wortmann RL, et al. Febuxostat compared with allopurinol in patients with hyperuricaemia and gout. N Engl J Med 2005 Dec 8; 353(23): 2450–61

    Article  PubMed  CAS  Google Scholar 

  7. Schumacher HR, Wortmann R, Becker M, et al. Long-term safety and efficacy of febuxostat, a novel non-purine selective inhibitor of xanthine oxidase, in subjects with hyperuricemia and gout [abstract no. SAT0282]. Ann Rheum Dis 2005 Jul; 64Suppl. 3: 498

    Google Scholar 

  8. Becker MA, Schumacher R, Wortmann R, et al. Febuxostat, a novel non-purine selective inhibitor of xanthine oxidase, therapy in allopurinol intolerant patients [abstract no. 803]. Arthritis Rheum 2004 Sep; 50(9 Suppl.): S336

    Google Scholar 

  9. Schumacher HR, Becker MA, Wortmann RL, et al. The FOCUS trial 48-month interim analysis: long-term clinical outcomes of treatment with febuxostat in subjects with gout in an ongoing phase 2, open-label extension study [abstract no. OP0130]. Ann Rheum Dis 2006 Jul; 65Suppl. II: 93

    Google Scholar 

  10. SchumacherJr HR, Becker MA, Wortmann RL, et al. Effects of febuxostat versus allopurinol and placebo in reducing serum urate in subjects with hyperuricaemia and gout: a 28-week, phase III, randomized, double-blind, parallel-group trial. Arthritis Rheum 2008 Oct 30; 59(ll): 1540–8

    Article  PubMed  CAS  Google Scholar 

  11. Becker MA, Schumacher HR, Wortmann RL, et al. The long-term clinical benefits of febuxostat vs allopurinol in subjects with gout: interim analysis of the EXCEL trial, an ongoing phase 3, open-label extension study [abstract no. FRI0483]. Ann Rheum Dis 2006 Jul; 65Suppl. II: 431

    Google Scholar 

  12. Becker MA, SchumacherJr HR, MacDonald PA, et al. Urate-lowering therapy (febuxostat or allopurinol) in subjects with gout interim results from the Febuxostat Comparative Extension Long-term Study (EXCEL) [abstract no. 757]. Arthritis Rheum 2007 Sep; 56(9 Suppl.): S322

    Google Scholar 

  13. Wortmann RL, Becker MA, Schumacher Jr HR, et al. Effect of febuxostat or allopurinol on the clinical manifestations of gout: reduction in gout flares and tophus size over time in the EXCEL trial [abstract no. 1592]. Arthritis Rheum 2006 Sep; 54(9 Suppl.): S642

    Google Scholar 

  14. British Medical Association and the Royal Pharmaceutical Society of Great Britain. British national formulary. No. 56. London: BMJ Publishing Group Ltd and RPS Publishing, 2008 Sep

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Febuxostat: a guide to its use in chronic hyperuricaemia. Drugs Ther. Perspect 25, 1–4 (2009). https://doi.org/10.2165/0042310-200925020-00001

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