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Antibacterial Therapy for Acute Group A Streptococcal Pharyngotonsillitis

Short-Course Versus Traditional 10-Day Oral Regimens

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Abstract

The objective of this review is to examine the use of short-course antibacterial therapy of group A β-hemolytic streptococcal (GABHS) pharyngotonsillitis, compared with traditional 10-day therapy. In preparing this paper we reviewed the medical literature of studies comparing 10 days of penicillin with shorter courses of antibacterial therapy.

Short-course therapy of 6 days of amoxicillin, 4 to 5 days of cephalosporins, and 5 days of azithromycin was found to be as, or more effective than traditional 10-day penicillin therapy. The benefits of short-course therapy include superior compliance and adherence, lower incidence of adverse effects, less effect on the bacterial flora, improved patient and parent satisfaction, and lower drug costs.

In conclusion, short courses of amoxicillin, cephalosporins, and macrolides provide superior or equal efficacy to a 10-day course of penicillin therapy in the treatment of GABHS pharyngotonsillitis.

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No sources of funding were used to assist in the preparation of this manuscript. The author has no conflicts of interest that are directly relevant to the content of this manuscript.

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  1. Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA

    Itzhak Brook

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Brook, I. Antibacterial Therapy for Acute Group A Streptococcal Pharyngotonsillitis. Pediatr-Drugs 4, 747–754 (2002). https://doi.org/10.2165/00128072-200204110-00006

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