Skip to main content
Log in

Optimal Management of Hair Loss (Alopecia) in Children

  • Therapy in Practice
  • Published:
American Journal of Clinical Dermatology Aims and scope Submit manuscript

Abstract

Hair loss in children encompasses a wide range of conditions that can be congenital or acquired. A congenital hair abnormality may be an isolated finding in an otherwise healthy child or may exist as a feature of a clinical syndrome. A thorough understanding of basic hair biology and normal hair development enables accurate assessment of the child with hair loss. Knowledge of the normal range and variation observed in children’s hair additionally enhances this assessment. Social and cultural factors also influence these norms.

The psychological and cosmetic importance of hair is immense in our society. The clinical presentation of pediatric hair disorders ranges from subtle to disfiguring. Management of hair disorders requires a holistic approach to the child and family. Young children usually lack self-awareness and it may be the parent who, projecting their own concerns onto the child, most acutely feels any associated anxiety. In addition, parents of a child with an inherited hair condition often feel guilt, and siblings can develop unsupported fears that they may be affected. Hair loss for the older child can lead to low self-esteem, depression and humiliation.

Congenital and hereditary hypotrichosis and hair shaft abnormalities often have no effective treatment. There is a variety of treatment options for alopecia areata and telogen effluvium, but no single treatment is 100% effective. Tinea capitis is an infective condition of the hair that responds readily to the appropriate medical therapy. If no effective treatment for the hair loss exists, cosmetic camouflage with wigs is the best option.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

Notes

  1. Use of tradenames is for product identification only and does not imply endorsement.

References

  1. Lavker RM, Bertolino AP, Klein LM, et al. Biology of hair follicles. In:Fitzpatick TB, Eisen AZ, Wollf K, et al., editors. Dermatology in general medicine. 5th ed., Boston: McGraw-Hill, 1993: 230–8

    Google Scholar 

  2. Sinclair RD, Banfield CC, Dawber RP. Hair structure and function. In: Sinclair RD, Banfield CC, Dawber RP, editors. Handbook of diseases of the hair and scalp. Oxford: Blackwell Science, 1999: 3–23

    Google Scholar 

  3. Kligman AM. The human hair cycle. J Invest Dermatol 1959; 33: 307–16

    Article  PubMed  CAS  Google Scholar 

  4. Wade M, Sinclair RD. Disorders of hair. In: Parish LC, Brenner S, Ramos-e-Silva M, editors. Women’s dermatology from infancy to maturity. Carnforth: Parthenon Publishing, 2001: 126–59

    Google Scholar 

  5. Dawber RP, de Berker D, Wojnarowska F. Disorders of the hair. In: Champion RH, Burton JL, Burns DA, Breathnach SM, editors. Rook/Wilkinson/Ebling textbook of dermatology. 6th ed. Oxford: Blackwell Science, 1998: 2885–973

    Google Scholar 

  6. Reynolds EL. The appearance of adult patterns of body hair in man. Ann N Y Acad Sci 1951; 53: 576–84

    Article  PubMed  CAS  Google Scholar 

  7. Gilhar A, Shalaginov R, Assy B, et al. Alopecia areata is a T-lymphocyte mediated autoimmune disease: lesional human T-lymphocytes transfer alopecia areata to human skin grafts on SCID mice. J Investig Dermatol Symp Proc 1999 Dec; 4 (3): 207–10

    Article  PubMed  CAS  Google Scholar 

  8. Safavi K. Prevalence of alopecia areata in the first national health and nutrition examination survey. Arch Dermatol 1992; 128: 702–4

    Article  PubMed  CAS  Google Scholar 

  9. Messenger R, Simpson N. Alopecia areata. In: Dawber R, editor. Diseases of the hair and scalp. Oxford: Blackwell Science, 1997: 338–69

    Google Scholar 

  10. Gip L, Lodin A, Molin L. Alopecia areata: a follow-up investigation of outpatient material. Acta Derm Venereol (Stockh) 1969; 49: 180–8

    CAS  Google Scholar 

  11. Green J, Sinclair RD. Genetics of alopecia areata. Australas J Dermatol 2000 Nov; 41 (4): 213–8

    Article  PubMed  CAS  Google Scholar 

  12. Muller SA, Winkelmann RK. Alopecia areata. Arch Dermatol 1963; 88: 106–13

    Google Scholar 

  13. Penders AJM. Alopecia areata and atopy. Dermatologica 1968; 136: 395–9

    Article  PubMed  CAS  Google Scholar 

  14. Duvic M, Nelson A, de Andrade M. The genetics of alopecia areata. Clin Dermatol 2001; 19 (2): 135–9

    Article  PubMed  CAS  Google Scholar 

  15. du Vivier A, Munro DD. Alopecia areata, autoimmunity and Down’s syndrome. BMJ 1975; 1: 191–2

    Article  PubMed  Google Scholar 

  16. Carter DM, Jegasothy BV. Alopecia areata and Down’s syndrome. Arch Dermatol 1976; 112: 1397–9

    Article  PubMed  CAS  Google Scholar 

  17. Sinclair RD, Banfield CC, Dawber RP. Alopecia areata. In: Sinclair RD, Banfield CC, Dawber RP, editors. Handbook of diseases of the hair and scalp. Oxford: Blackwell Science, 1999: 139–40

    Google Scholar 

  18. Eckert J, Church RE, Ebling FJ. The pathogenesis of alopecia areata. Br J Dermatol 1968; 80: 203–10

    Article  PubMed  CAS  Google Scholar 

  19. Muralidhar S, Sharma VK, Kaur S. Ophiasis inversus: a rare pattern of alopecia areata [letter]. Pediatr Dermatol 1998; 15: 326–7

    Article  PubMed  CAS  Google Scholar 

  20. Madini S, Shapiro J. Alopecia areata update. J Am Acad Dermatol 2000; 42: 549–66

    Google Scholar 

  21. Mitchell A, Krull E. Alopecia areata: pathogenesis and treatment. J Am Acad Dermatol 1984; 11: 763–75

    Article  PubMed  CAS  Google Scholar 

  22. So A. Genetics, polymorphism and regulation of expression of HLA region genes. In:Lecher R, editor. HLA and disease. San Diego (CA): Academic Press, 1994: 1

    Google Scholar 

  23. Price VH, Colombe BW. Heritable factors distinguish two types of alopecia areata. Dermatol Clin 1996; 14: 679–89

    PubMed  CAS  Google Scholar 

  24. Colombe BW, Price VH, Khoury EL. HLA class II antigen association help to define two types of alopecia areata. J Am Acad Dermatol 1995; 33: 757–64

    PubMed  CAS  Google Scholar 

  25. Frentz G, Thomsen K, Jakobsen BK, et al. HLA-DR4 in alopecia areata [letter]. J Am Acad Dermatol 1986; 14: 129–30

    Article  PubMed  CAS  Google Scholar 

  26. Orrechia G, Belvedere MC, Martinetti M. Human leukocyte antigen region involvement in the genetic predisposition to alopecia areata. Dermatologica 1987; 175: 10–4

    Article  Google Scholar 

  27. Duvic M, Hordinsky MK, Fiedler VC. HLA-D locus associations in alopecia areata Drw52a may confer disease resistance. Arch Dermatol 1991; 127: 64–8

    Article  PubMed  CAS  Google Scholar 

  28. Welsh EA, Clark HH, Zane S, et al. Human leukocyte antigen DQB01*03 alleles are significantly associated with alopecia areata. J Invest Dermatol 1994; 103: 758–63

    Article  PubMed  CAS  Google Scholar 

  29. Duvic M, Welsh EA, Jackow C, et al. Analysis of HLA-D locus alleles in alopecia areata patients and their families. Arch Dermatol 1995; 104 (5 Suppl.): 5S-6S

    Google Scholar 

  30. Tarlow JK, Clay FE, Cork MJ. Severity of alopecia areata is associated with a polymorphism in the interleukin-1 receptor antagonist gene. J Invest Dermatol 1994; 103: 387–90

    Article  PubMed  CAS  Google Scholar 

  31. Fiedler VC. Alopecia areata: a review of therapy, efficacy, safety and mechanism. Arch Dermatol 1992; 128: 1519–29

    Article  PubMed  CAS  Google Scholar 

  32. Gill KA, Baxter DL. Alopecia totalis: treatment with fluocinolone acetonide. Arch Dermatol 1963; 87: 384–6

    Article  PubMed  Google Scholar 

  33. Leyden JJ, Kligman AM. Treatment of alopecia areata with steroid solution [letter]. Arch Dermatol 1972; 106: 924

    Article  PubMed  CAS  Google Scholar 

  34. Pascher F, Kurtin S, Andrade E. Assay of 0.2% fluocinolone acetonide cream for alopecia areata and totalis. Dermatologica 1970; 141: 193–202

    Article  PubMed  CAS  Google Scholar 

  35. Abell E, Munro DD. Intralesional treatment of alopecia areata with triamcinolone acetonide by jet injector. Br J Dermatol 1979; 88: 55–9

    Article  Google Scholar 

  36. Schmoekel C, Weissman I, Plewig G, et al. Treatment of alopecia areata by anthralin-induced dermatitis. Arch Dermatol 1979; 115: 1254–5

    Article  Google Scholar 

  37. Fiedler-Weiss VC, Buys CM. Evaluation of anthralin in the treatment of alopecia areata. Arch Dermatol 1987; 123: 1491–3

    Article  PubMed  CAS  Google Scholar 

  38. Price VH. Double-blind, placebo-controlled evaluation of topical minoxidil in extensive alopecia areata. J Am Acad Dermatol 1987; 16: 730–6

    Article  PubMed  CAS  Google Scholar 

  39. Price VH. Topical minoxidil (3%) in extensive alopecia areata including long term efficacy. J Am Acad Dermatol 1987; 16: 737–44

    Article  PubMed  CAS  Google Scholar 

  40. Kratha J, Goerz G, Vizethum W. Dinitrochlorobenzene: influence on the cytochrome P450 system and mutagenic effects. Arch Dermatol Res 1979; 266: 315–8

    Article  Google Scholar 

  41. Wiseman MC, Shapiro J, MacDonald N, et al. Predictive model for immunotherapy of alopecia areata with diphencyprone. Arch Dermatol 2001; 137: 1063–8

    PubMed  CAS  Google Scholar 

  42. Schuttelaar M-LA, Hamstra JJ, Plink EPB, et al. Alopecia areata in children: treatment with diphencyprone. Br J Dermatol 1996; 135: 581–5

    Article  PubMed  CAS  Google Scholar 

  43. MacDonald Hull SP, Pepall L, Cunliffe WJ. Alopecia areata in children: response to treatment with diphencyprone. Br J Dermatol 1991; 125: 164–8

    Article  Google Scholar 

  44. Orecchia G, Malagoli P. Topical immunotherapy in children with alopecia areata. J Invest Dermatol Suppl 1995; 104: 35S-6S

    Google Scholar 

  45. Tosti A, Guidetti MS, Bardazzi F, et al. Long-term results of topical immunotherapy in children with alopecia totalis or alopecia universalis. J Am Acad Dermatol 1996; 35: 199–201

    Article  PubMed  CAS  Google Scholar 

  46. Pardasani AG, Turner E, McMichael AJ. Squaric acid dibutylester: indications for use and efficacy in alopecia areata. Arch Dermatol 2001; 137: 970–2

    PubMed  CAS  Google Scholar 

  47. Kligman A. Pathological dynamics of reversible hair loss in humans: I. telogen effluvium: Arch Dermatol 1961; 83: 175–98

    Article  PubMed  CAS  Google Scholar 

  48. Headington J. Telogen effluvium: new concepts and review. Arch Dermatol 1993; 129: 356–63

    Article  PubMed  CAS  Google Scholar 

  49. Wise RP, Kiminyo KP, Salive ME. Hair loss after routine immunization. JAMA 1997; 278: 1176–8

    Article  PubMed  CAS  Google Scholar 

  50. Sinclair R. Diffuse hair loss. Int J Dermatol 1999; 38 Suppl. 1: 8–18

    Article  PubMed  Google Scholar 

  51. Sinclair R. There is no clear association between low serum ferritin and chronic diffuse telogen hair loss. Br J Dermatol 2002; 147: 982–4

    Article  PubMed  CAS  Google Scholar 

  52. Whiting D. Chronic telogen effluvium. Dermatol Clin 1996; 14 (4): 723–31

    Article  PubMed  CAS  Google Scholar 

  53. Feidler VV, Hafeez A. Diffuse alopecia: telogen hair loss. In: Olsen EA, editor. Disorders of hair growth; diagnosis and treatment (New York (NY)): McGraw-Hill, 1994: 249–52

    Google Scholar 

  54. Comaish J. Metabolic disorders and hair growth. Br J Dermatol 1971; 84: 83–5

    Article  PubMed  CAS  Google Scholar 

  55. Rook A. Endocrine influences on hair growth. BMJ 1965; 1: 609–14

    Article  PubMed  CAS  Google Scholar 

  56. Weismann K. Zinc metabolism and the skin. In: Rook ASJ, Savin JA, editors. Recent advances in dermatology 5. Edinburgh: Churchill Livingston, 1980: 109–29

    Google Scholar 

  57. Kennedy C. Syphilis presenting as hair loss. BMJ 1976; II: 854–5

    Article  Google Scholar 

  58. Elston D, Bergfield W. Cicatricial alopecia (and other causes of permanent hair loss). In:Olsen EA, editor. Disorders of hair growth; diagnosis and treatment. New York (NY): McGraw Hill, 1994: 287

    Google Scholar 

  59. Bradfield R, Bailley M. Hair root response to protein undernutrition. In: Montagna W, Dobson R, editors. Advances in biology of the skin: vol. IX, hair growth. Oxford: Pergamon, 1968: 109

    Google Scholar 

  60. Skolnik P, Eaglstein W, Ziboh V. Human essential fatty acid deficiency. Arch Dermatol 1977; 113: 939–41

    Article  PubMed  CAS  Google Scholar 

  61. Wells G. Skin disorders in relation to malabsorption. BMJ 1962; 2: 937–9

    Article  PubMed  CAS  Google Scholar 

  62. Van Dijke CP, Heydendael RJ, de Kleine MJ. Methimazole, carbimazole and congenital skin defects. Ann Intern Med 1987; 106: 60–1

    PubMed  Google Scholar 

  63. Sinclair RD, Banfield CC, Dawber RP. Hereditary and congenital alopecias and hypotrichosis. In: Sinclair RD, Banfield CC, Dawber RP, editors. Handbook of diseases of the hair and scalp. Oxford: Blackwell Science, 1999: 129–55

    Google Scholar 

  64. Trakimas CA, Sperling LC. Temporal triangular alopecia acquired in adulthood. J Am Acad Dermatol 1999; 40: 842–4

    Article  PubMed  CAS  Google Scholar 

  65. Sprecher E, Bergman R, Szargel R. Atrichic with papular lesions maps to 8p in the region containing the human hairless gene. Am J Hum Genet 1998; 80 (5): 546–50

    CAS  Google Scholar 

  66. Roberts JL, Whiting DA, Henry D, et al. Marie Unna congenital hypotrichosis: clinical description, histopathology, scanning electron microscopy of a previously unreported large pedigree. J Invest Dermatol Symp Proc 1999 Dec; 4 (3): 261–7

    Article  CAS  Google Scholar 

  67. Roberts JL, Wong CQ, Stenn KS. Marie Unna hereditary hypotrichosis gene maps to human chromosome 8p21 near hairless. J Invest Dermatol 2000; 114: 595–7

    Article  PubMed  Google Scholar 

  68. Van Steensel M, Smith FJ, Steijlen PM, et al. The gene for hypotrichosis of Marie Unna maps between D8S258 and D8S298: exclusion of the hr gene by cDNA and genomic sequencing. Am J Hum Genet 1999; 65: 413–9

    Article  PubMed  Google Scholar 

  69. Happle R. Genetic hair loss. Clin Dermatol 2001 Mar/Apr; 19 (2): 121–8

    Article  PubMed  CAS  Google Scholar 

  70. de Berker D, Sinclair RD. The hair shaft: normality, abnormality, and genetics. Clin Dermatol 2001 Mar/Apr; 19 (2): 129–34

    Article  PubMed  Google Scholar 

  71. Sinclair RD, Banfield CC, Dawber RPR. Structural abnormalities of the hair shaft. In: Sinclair RD, Banfield CC, Dawber RP, editors. Handbook of diseases of the hair and scalp. Oxford: Blackwell Science, 1999: 156–87

    Google Scholar 

  72. McGowan KM, Coulombe PA. Keratin 17 expression in the hard epithelial context of the hair and nail, and its relevance for the pachyonychia congenita phenotype. J Invest Dermatol 2000; 114: 1101–7

    Article  PubMed  CAS  Google Scholar 

  73. Bjornstad RT. Pili torti and sensory-neural loss of hearing. Paper presented at the 17th Combined Dermatological Association Meeting, Copenhagen, Denmark: May 27–29 1965, Copenhagen

    Google Scholar 

  74. Lubianca Neto JF, Lu L, Eavey RD, et al. The Bjornstad syndrome (sensorineural hearing loss and pili torti) gene maps to chromosome 2q34–36. Am J Hum Genet 1998; 62: 1107–12

    Article  PubMed  CAS  Google Scholar 

  75. Tumer Z, Tommerup N, Tonnesen T, et al. Mapping of the Menke’s locus to Xq13.3 distal to the X-activation center by an intrachromosomal insertion of the segment Xq13.3-q21.2. Hum Genet 1992; 88: 668–72

    Article  PubMed  CAS  Google Scholar 

  76. Vulpe C, Levison B, Whitney S, et al. Isolation of a candidate gene for Menke’s disease and evidence that it encodes a copper-transporting ATPase. Nat Genet 1993; 3: 7–13

    Article  PubMed  CAS  Google Scholar 

  77. Jones LN. Investigation of structural proteins in human hair defects using anagen follicles. Br J Dermatol 1996; 135: 80–5

    Article  PubMed  CAS  Google Scholar 

  78. Healy E, Holmes SC, Belgaid CE, et al. A gene for monilethrix is closely linked to the type II keratin gene cluster at 12q13. Hum Mol Genet 1995; 4 (12): 2399–402

    Article  PubMed  CAS  Google Scholar 

  79. Winter H, Rogers MA, Langbein L, et al. Mutations in the hair cortex keratin hHhB6 cause the inherited hair disease monilethrix. Nat Genet 1997; 16: 372–4

    Article  PubMed  CAS  Google Scholar 

  80. Winter H, Rogers MA, Gebhardt M, et al. A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix. Hum Genet 1997; 101: 165–9

    Article  PubMed  CAS  Google Scholar 

  81. Chavanas S, Garner C, Bodemer C, et al. Localisation of the Netherton syndrome gene to chromosome 5q32, by linkage analysis and homozygosity mapping. Am J Am Genet 2000; 66: 914–21

    Article  CAS  Google Scholar 

  82. Chavanas S, Bodemer C, Rochat A, et al. Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome. Nat Genet 2000; 25: 141–2

    Article  PubMed  CAS  Google Scholar 

  83. Hamm H, Traupe H. Loose anagen hair of childhood: the phenomenon of easily pluckable hair. J Am Acad Dermatol 1989; 20: 242–8

    Article  PubMed  CAS  Google Scholar 

  84. Sinclair RD, Cargnello J, Chow CW. Loose anagen syndrome. Exp Dermatol 1999; 8 (4): 297–8

    PubMed  CAS  Google Scholar 

  85. Sinclair RD, Banfield CC, Dawber RPR. Non-scarring traumatic alopecia. In:Sinclair RD, Banfield CC, Dawber RPR,editors. Handbook of diseases of the hair and scalp. Oxford: Blackwell Science, 1999: 85–91

    Google Scholar 

  86. Whiting DA. Traumatic alopecia. Int J Dermatol 1998; 38 Suppl. 1: 34–44

    Article  Google Scholar 

  87. Sogair SA. Fungal infections in children: tinea capitis. Clin Dermatol 2000; 18: 679–85

    Article  PubMed  Google Scholar 

  88. Sinclair RD, Banfield CC, Dawber RPR. Infections and infestations of the hair. In: Sinclair RD, Banfield CC, Dawber RPR, editors. Handbook of diseases of the hair and scalp. Oxford: Blackwell Science, 1999: 191–200

    Google Scholar 

  89. Elewski BE. Tinea capitis: a current perspective. J Am Acad Dermatol 2000; 42 (1): 1–20

    Article  PubMed  CAS  Google Scholar 

  90. Aly R. Ecology and epidemiology of dermatophyte infections. J Am Acad Dermatol 1994; 31 (3 Pt 2): S21–5

    Article  Google Scholar 

  91. Hay RJ, Clayton YM, De Silva N, et al. Tinea capitis in south-east London: a new pattern of infection with public health implications. Br J Dermatol 1996; 135: 955–8

    Article  PubMed  CAS  Google Scholar 

  92. Kemna ME, Elewski BE. A US epidemiologic survey of superficial fungal diseases. J Am Acad Dermatol 1996; 35: 539–42

    Article  PubMed  CAS  Google Scholar 

  93. Higgins EM, Fuller LC, Smith CH. Guidelines for the management of tinea capitis. Br J Dermatol 2000; 143: 53–8

    Article  PubMed  CAS  Google Scholar 

  94. Hay RJ, Moore M. Mycology. In: Champion RH, Burton JL, Burns DA, Breathnach SM, editors. Textbook of dermatology. 6th ed. Oxford: Blackwell Science, 1988: 1277–376

    Google Scholar 

  95. Babel DE, Baughman SA. Evaluation of the adult carrier state in juvenile tinea capitis. J Am Acad Dermatol 1989; 21: 1209–12

    Article  PubMed  CAS  Google Scholar 

  96. Carslaw RW. Favus of the scalp: observations on the manner of spread. Br J Dermatol 1955; 67: 392–6

    Article  PubMed  CAS  Google Scholar 

  97. MacKenzie DWR, Burrows D, Walby AL. Trichophyton sulphureum in a residential school. BMJ 1960; 2: 1055–8

    Article  PubMed  CAS  Google Scholar 

  98. Dawber RPR, Fenton DA. Infections and infestations. In: Dawber RPR, editor. Diseases of the hair and scalp. 3rd ed. Oxford: Blackwell Science, 1997: 418–60

    Google Scholar 

  99. Wade MS, Sinclair RD. Disorders of hair in infants and children other than alopecia. Clin Dermatol 2002; 20: 16–28

    Article  PubMed  Google Scholar 

  100. Elewski BE. Treatment of tinea capitis: beyond griseofulvin. J Am Acad Dermatol 1999; 40 (6 Pt 2): S27–30

    Article  Google Scholar 

  101. Elewski BE. Treatment of tinea capitis with itraconazole. Int J Dermatol 1997; 36: 537–41

    Article  Google Scholar 

  102. Abdel-Rahman SM, Powell DA, Nahata MC. Efficacy of itraconazole in children with Trichophyton tonsurans tinea capitis. J Am Acad Dermatol 1998; 38: 443–6

    Article  PubMed  CAS  Google Scholar 

  103. Lopez-Gomez S, Del Palacio A, Van Custem J, et al. Itraconazole versus griseofulvin in the treatment of tinea capitis: a double-blind randomized control study in children. Int J Dermatol 1994; 33: 743–7

    Article  PubMed  CAS  Google Scholar 

  104. Mercurio MG, Silverman R, Elewski BE. Tinea capitis: fluconazole in Trichophyton tonsurans infection. Pediatr Dermatol 1998; 15: 229–32

    Article  PubMed  CAS  Google Scholar 

  105. Soloman BA, Collins R, Sharma R, et al. Fluconazole for the treatment of tinea capitis in children. J Am Acad Dermatol 1997; 37: 274–5

    Article  Google Scholar 

Download references

Acknowledgments

No sources of funding were used to assist in the preparation of this manuscript. The authors have no conflicts of interest that are directly relevant to the content of this manuscript.

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Harrison, S., Sinclair, R. Optimal Management of Hair Loss (Alopecia) in Children. Am J Clin Dermatol 4, 757–770 (2003). https://doi.org/10.2165/00128071-200304110-00004

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00128071-200304110-00004

Keywords

Navigation