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Hypotensive Potential of Sildenafil and Tamsulosin during Orthostasis

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Abstract

We describe pronounced hypotension in a patient during orthostatic testing while receiving treatment with sildenafil and tamsulosin, but not with placebo. The patient was 71 years of age and had no history of orthostatic reactions. He had been diagnosed with benign prostatic hyperplasia (BPH) and glaucoma simplex (open-angle glaucoma). The only regular medication used was a combination of latanoprost and timolol one drop daily into each eye. The patient was among 16 men with BPH enrolled in a study of the haemodynamic effects of tamsulosin and sildenafil. The present patient was excluded from data analysis because of atypical reactions: he experienced a decrease in peripheral vascular resistance upon orthostasis during treatment with sildenafil and tamsulosin. This led to marked hypotension and cancellation of the tilt tests with both sildenafil alone (Riva-Rocci [RR] 75/50mm Hg) and a combination of sildenafil and tamsulosin (RR 60/45mm Hg); however, tamsulosin alone also lowered blood pressure to some extent (RR 100/80mm Hg). In conclusion, even though sildenafil and tamsulosin are considered haemodynamically safe, they may induce considerable vasodilation and, subsequently, harmful hypotension in susceptible patients.

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Acknowledgements

Financial support has been received from the Medical Research Fund of Tampere University Hospital. None of the authors have any conflicts of interest.

Study nurse Pirjo Järventausta is acknowledged for her skilful technical assistance.

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Authors and Affiliations

  1. Department of Pharmacological Sciences, Medical School, University of Tampere, FI-33014, Tampere, Finland

    Tuomo Nieminen

  2. Department of Clinical Physiology, Medical School, University of Tampere, Tampere, Finland

    Tiit Kööbi & Mika Kähönen

  3. Tampere University Hospital, Tampere, Finland

    Tiit Kööbi, Teuvo L. J. Tammela & Mika Kähönen

  4. Department of Urology, Medical School, University of Tampere, Tampere, Finland

    Teuvo L. J. Tammela

Authors
  1. Tuomo Nieminen
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  2. Tiit Kööbi
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  3. Teuvo L. J. Tammela
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  4. Mika Kähönen
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Correspondence to Tuomo Nieminen.

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Nieminen, T., Kööbi, T., Tammela, T.L.J. et al. Hypotensive Potential of Sildenafil and Tamsulosin during Orthostasis. Clin. Drug Investig. 26, 667–671 (2006). https://doi.org/10.2165/00044011-200626110-00007

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  • DOI: https://doi.org/10.2165/00044011-200626110-00007

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