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Correlation between Nonsteroidal Anti-Inflammatory Drug Efficacy in a Clinical Pain Model and the Dissociation of their Anti-Inflammatory and Analgesic Properties in Animal Models

  • Original Research
  • Pharmacodynamics
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Summary

Recently our group demonstrated that it is possible to differentiate nonsteroidal anti-inflammatory drugs (NSAIDs) as analgesic agents in the management of acute musculoskeletal pain. In this paper, we extend this work to investigate the notion that the analgesic and anti-inflammatory potency of an NSAID is not simply related through a common mechanism, namely the inhibition of peripheral prostaglandin (PG) synthesis. Following an extensive survey of the published literature for a series of acidic NSAIDs, we could not find any significant correlation between potency as an analgesic agent or as an anti-inflammatory agent and analgesic efficacy in clinical practice. Importantly, we now demonstrate for the first time that it is potency as an analgesic agent relative to potency as an anti-inflammatory agent that covaries with clinical efficacy. We discuss the possibility that, for a given NSAID, the magnitude of this dissociation between analgesic and anti-inflammatory potencies may reflect the net effect of a complex interaction between peripheral and central sites of action, and between diverse mechanisms of action that are independent of an inhibition of PG synthesis. Our results provide a clinically meaningful differentiation of NSAIDs through the use of in vivo data.

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McCormack, K., Urquhart, E. Correlation between Nonsteroidal Anti-Inflammatory Drug Efficacy in a Clinical Pain Model and the Dissociation of their Anti-Inflammatory and Analgesic Properties in Animal Models. Clin. Drug Invest. 9, 88–97 (1995). https://doi.org/10.2165/00044011-199509020-00005

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