Summary
Melasma is an acquired hyperpigmentary disorder commonly seen in Orientals. The pattern of pigmentary change in this condition is very characteristic and the diagnosis is usually evident to the patient. A number of pigmentary disorders mimicking melasma have been reported in Asian people. They include Riehl’s melanosis, pigmented actinic lichen planus, and acquired bilateral naevus of Otalike macules. Increased awareness of these pigmentary disorders should lead to the correct diagnosis.
Data on the prevalence of melasma are very limited. In South East Asia, melasma accounts for 0.25 to 4% of patients seen in dermatology institutes, with peak incidence in those aged 30 to 44 years. The disorder is seen much more commonly in females than in males. Although the general prevalence of this condition in the population is not known, one simple survey suggests that the prevalence of melasma may be as high as 40% in females and 20% in males.
Multiple causative factors have been implicated in the aetiology of melasma; of these, sunlight appears to be the most important in causing and aggravating the condition in susceptible individuals. Genetic factors are also important: in many studies, 20 to 70% of patients reported having close relatives who were similarly affected. In about 10 to 20% of patients with melasma, the use of contraceptive pills has been implicated as the cause of this disorder.
Adverse effects resulting from self-medication and treatments offered by beauticians are frequently encountered. Treatments provided by dermatologists are generally safer and much more effective. The mainstay of treatment is the proper use of safe depigmenting agents. Additional measures such as avoidance of sunlight are important for achieving good therapeutic results.
Similar content being viewed by others
References
Jimbow M, Jimbow K. Pigmentary disorders in Oriental skin. Clin Dermatol 1989; 7: 11–27
Sanchez N, Pathak MA, Sato S, et al. Melasma: a clinical, light microscopic, ultrastructural and immunofluorescence study. J Am Acad Dermatol 1981; 4: 698–710
Vazquez M, Maldonado H, Benmaman C, et al. Melasma in men, a clinical and histologic study. Int J Dermatol 1988; 27: 25–7
Rorsman H. Riehl’s melanosis. Int J Dermatol 1982; 21: 75–8
Nagao S, Tanno K, Ijima S. Riehl’s melanosis and pigmentation after patch testing: light and electron microscopic study. In: Fitzpatrick TB, Kukita A, Morikawa F, et al., editors. Biology and diseases of dermal pigmentation. Tokyo: University of Tokyo Press, 1981: 209–23
Al-fouzan AS, Hassab-el-naby HMM. Melasma-like (pigmented) actinic lichen planus. Int J Dermatol 1992; 31: 413–5
Salman S, Khallouf R, Zaynoun S. Actinic lichen planus mimicking melasma. J Am Acad Dermatol 1988; 18: 275–8
Hori Y, Kawashima M, Oohara K, et al. Acquired, bilateral nevus of Ota-like macules. J Am Acad Dermatol 1984; 10: 961–4
Suvanprakom P. Special problems among Orientals with the use of cosmetic products. In: Frost P, Horwitz SN, editors. Principles of cosmetics for dermatologists. St Louis: CV Mosby, 1982: 305–9
Kotrajaras R. The report on improvement of dermatological practices in Thailand: submitted to international development research center, Ottawa, Canada. Bangkok: Institute of Dermatology; 1984
Verallo-Rowell WM, Verallo V, Graupe K, et al. Double blind comparison of azelaic acid and hydroquinone in the treatment of melasma. Acta Derm Venereol 1989; 143 Suppl.: 58–61
Pathak MA. Clinical and therapeutic aspects of melasma: an overview. In: Fitzpatrick TB, Wick MM, Toda K, editors. Brown melamoderma. Tokyo: University of Tokyo Press, 1986: 161–72
Griffiths CEM, Finkel LJ, Ditre CM, et al. Topical tretinoin (retinoic acid) improves melasma: a vehicle-controlled clinical trial. Br J Dermatol 1993; 129: 415–21
Resnik S. Melasma induced by oral contraceptive drugs. JAMA 1967; 199(9): 601–5
Lufti R, Fridmanis M, Misiunas AL, et al. Association of melasma with thyroid autoimmunity and other thyroidal abnormalities and their relationship to the origin of melasma. J Clin Endocrinol Metab 1985; 61: 28–31
Kligman AM, Willis I. A new formula for depigmenting human skin. Arch Dermatol 1975; 111: 40–8
Sivayathom A, Verallo-Rowell V, Graupe K. 20% azelaic acid in the topical treatment of melasma: a double-blind comparison with 2% hydroquinone. Eur J Dermatol. In press
Engasser PG, Maibach HI. Cosmetics and dermatology: bleaching creams. J Am Acad Dermatol 1981; 5: 143–7
Verallo-Rowell V, Sioson-delos Reyes G. South East Asian experience with azelaic acid in melasma. Med Prog 1993; 20 Suppl.: 26–30
Balina LM, Graupe K. The treatment of melasma. 20% azelaic acid versus 4% HQ cream. Int J Dermatol 1991; 30: 893–5
Gano SE, Garcia RL. Topical tretinoin, hydroquinone and betamethasone valerate in the therapy of melasma. Cutis 1979; 23: 239–41
Verallo-Rowell VM, Verallo V, Zaumseil RP, et al. Combined use of 20% azelaic acid cream and 0.05% tretinoin in topical treatment of melasma. J Derm Treat. In press
Mishima Y. Advances in pathogenesis and treatment of pigmentary disorders. In: Orfanos CE, et al., editors. Dermatology in five continents. Berlin: Springer Verlag, 1988: 132–9
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sivayathorn, A. Melasma in Orientals. Clin. Drug Invest. 10 (Suppl 2), 34–40 (1995). https://doi.org/10.2165/00044011-199500102-00006
Published:
Issue Date:
DOI: https://doi.org/10.2165/00044011-199500102-00006