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Current Views on Melasma

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Pigmentary Skin Disorders

Part of the book series: Updates in Clinical Dermatology ((UCD))

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Abstract

Melasma is a common acquired hyperpigmentary disorder of the face mostly in women with darker skin types. Chronic sun exposure, genetic influences, and female sex hormones have been addressed as major etiological factors. The pathogenesis of melasma is not fully understood, but current studies suggest that endogenous or exogenous stimuli may stimulate the microenvironment, leading to the release of various mediators that activate melanocytes in the development of melasma. In melasma skin, not only melanocytes but other actors, especially dermal components such as photoaged fibroblasts or vasculature, most likely play a key role in the development and in relapses of melasma. Treatment of melasma is difficult because it is recalcitrant to therapy and frequently recurs, even after successful clearance. There are various treatment options, usually in combination with topical depigmenting agents, laser or light therapies, as well as systemic tranexamic acid.

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Authors and Affiliations

  1. Department of Dermatology, Seoul National University Bundang Hospital, Seongnam, Korea

    Kyoung-Chan Park

  2. Department of Dermatology, Ajou University School of Medicine, Suwon, Korea

    Hee Young Kang

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  1. Department of Dermatology, Fiona Stanley Hospital and University of Western Australia, Perth, Western Autralia, Australia

    Prasad Kumarasinghe

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Park, KC., Kang, H.Y. (2018). Current Views on Melasma. In: Kumarasinghe, P. (eds) Pigmentary Skin Disorders. Updates in Clinical Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-70419-7_12

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