Skip to main content
SpringerLink
Log in

Inhaled corticosteroids appear to have little risk of causing adverse effects on growth, bdbone density or cortisol levels in children with asthma

  • Drug Reactions and Interaction
  • Published:
Drugs & Therapy Perspectives Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Table I

References

  1. Pedersen S. Clinical safety of inhaled corticosteroids for asthma in children: an update of long-term trials. Drug Saf 2006: 29(7): 599–612

    Article  PubMed  CAS  Google Scholar 

  2. Price JF, Russell G, Hindmarsh PC, et al. Growth during one year of treatment with fluticasone propionate or sodium cromoglycate in children with asthma. Pediatr Pulmonol 1997; 24: 178–86

    Article  PubMed  CAS  Google Scholar 

  3. Bisgaard H, Allen D, Milanowski J, et al. Twelve-month safety and efficacy of inhaled fluticasone propionate in children aged 1 to 3 years with recurrent wheezing. Pediatrics 2004; 113: e87–94

    Article  PubMed  Google Scholar 

  4. Merkus PJ, van Essen-Zandvliet EE, Duiverman EJ, et al. Long-term effect of inhaled corticosteroids on growth rate in adolescents with asthma. Pediatrics 1993; 91: 1121–6

    PubMed  CAS  Google Scholar 

  5. Tinkelman DG, Reed CE, Nelson HS, et al. Aerosol beclometasone compared with theophylline as primary treatment of chronic, mild to moderately severe asthma in children. Pediatrics 1993; 92: 64–77

    PubMed  CAS  Google Scholar 

  6. Rao R, Gregson RK, Jones AC, et al. Systemic effects of inhaled corticosteroids on growth and bone turnover in childhood asthma: a comparison of fluticasone with beclomethasone. Eur Respir J 1999; 13: 87–94

    Article  PubMed  CAS  Google Scholar 

  7. Allen DB, Bronsky EA, LaForce CF, et al. Growth in asthmatic children treated with fluticasone propionate. Fluticasone Propionate Asthma Study Group. J Pediatr 1998; 132: 472–7

    Article  PubMed  CAS  Google Scholar 

  8. Roux C, Kolta S, Desfougeres JL, et al. Long-term safety of fluticasone propionate and nedocromil sodium on bone in children with asthma. Pediatrics 2003; 111: e706–13

    Article  PubMed  Google Scholar 

  9. Jonasson G, Carlsen KH, Jonasson C, et al. Low-dose inhaled budesonide once or twice daily for 27 months in children with mild asthma. Allergy 2000; 55: 740–8

    Article  PubMed  CAS  Google Scholar 

  10. Bacharier LB, Raissy HH, Wilson L, et al. Long-term effect of budesonide on hypothalamic-pituitary-adrenal axis function in children with mild to moderate asthma. Pediatrics 2004; 113: 1693–9

    Article  PubMed  Google Scholar 

  11. Childhood Asthma Management Program Research Group. Long-term effects of budesonide or nedocromil in children with asthma. N Engl J Med 2000; 343: 1054–63

    Article  Google Scholar 

  12. Verberne AA, Frost C, Roorda RJ, et al. One year treatment with salmeterol compared with beclomethasone in children with asthma. The Dutch Paediatric Asthma Study Group. Am J Respir Crit Care Med 1997; 156: 688–95

    PubMed  CAS  Google Scholar 

  13. Simons FE. A comparison of beclomethasone, salmeterol, and placebo in children with asthma. Canadian Beclomethasone Dipropionate-Salmeterol Xinafoate Study Group. N Engl J Med 1997; 337: 1659–65

    Article  PubMed  CAS  Google Scholar 

  14. Visser MJ, van der Veer E, Postma DS, et al. Side-effects of fluticasone in asthmatic children: no effects after dose reduction. Eur Respir J 2004; 24: 420–5

    Article  PubMed  CAS  Google Scholar 

  15. Verona E, Petrov D, Cserhati E, et al. Fluticasone propionate in asthma: a long term dose comparison study. Arch Dis Child 2003; 88: 503–9

    Article  PubMed  CAS  Google Scholar 

  16. de Benedictis FM, Teper A, Green RJ, et al. Effects of 2 inhaled corticosteroids on growth: results of a randomized controlled trial. Arch Pediatr Adolesc Med 2001; 155: 1248–54

    PubMed  Google Scholar 

  17. Skoner DP, Szefler SJ, Welch M, et al. Longitudinal growth in infants and young children treated with budesonide inhalation suspension for persistent asthma. J Allergy Clin Immunol 2000; 105: 259–68

    Article  PubMed  CAS  Google Scholar 

  18. Scott MB, Skoner DP. Short-term and long-term safety of budesonide inhalation suspension in infants and young children with persistent asthma. J Allergy Clin Immunol 1999; 104: 200–9

    Article  PubMed  CAS  Google Scholar 

  19. Leflein JG, Szefler SJ, Murphy KR, et al. Nebulized budesonide inhalation suspension compared with cromolyn sodium nebulizer solution for asthma in young children: results of a randomized outcomes trial. Pediatrics 2002; 109: 866–72

    Article  PubMed  Google Scholar 

  20. Pedersen S. Do inhaled corticosteroids inhibit growth in children? Am J Respir Crit Care Med 2001; 164: 521–35

    PubMed  CAS  Google Scholar 

  21. Agertoft L, Pedersen S. Effect of long-term treatment with inhaled budesonide on adult height in children with asthma. N Engl J Med 2000; 343: 1064–9

    Article  PubMed  CAS  Google Scholar 

  22. Larsson L, Gerhardsson de Verdier M, Lindmark B, et al. Budesonide-treated asthmatic adolescents attain target height: a population-based follow-up study from Sweden. Pharmacoepidemiol Drug Saf 2002; 11: 715–20

    Article  PubMed  CAS  Google Scholar 

  23. Inoue T, Doi S, Takamatsu I, et al. Effect of long-term treatment with inhaled beclometasone on growth of asthmatic children. J Asthma 1999; 36: 159–64

    Article  PubMed  CAS  Google Scholar 

  24. Silverstein MD, Yunginger JW, Reed CE, et al. Attained adult height after childhood asthma: effect of glucocorticoid therapy. J Allergy Clin Immunol 1997; 99: 466–74

    Article  PubMed  CAS  Google Scholar 

  25. Van Bever HP, Desager KN, Lijssens N, et al. Does treatment of asthmatic children with inhaled corticosteroids affect their adult height? Pediatr Pulmonol 1999; 27: 369–75

    Article  PubMed  Google Scholar 

  26. Norjavaara E, Gerhardsson De Verdier M, Lindmark B. Reduced height in Swedish men with asthma at the age of conscription for military service. J Pediatr 2000; 137: 25–9

    Article  PubMed  CAS  Google Scholar 

  27. Schlienger RG, Jick SS, Meier CR. Inhaled corticosteroids and the risk of fractures in children and adolescents. Pediatrics 2004; 114: 469–73

    Article  PubMed  Google Scholar 

  28. van Staa TP, Bishop N, Leufkens HG, et al. Are inhaled corticosteroids associated with an increased risk of fracture in children? Osteoporos Int 2004; 15: 785–91

    Article  PubMed  CAS  Google Scholar 

  29. Todd GR, Acerini CL, Ross-Russell R, et al. Survey of adrenal crisis associated with inhaled corticosteroids in the United Kingdom. Arch Dis Child 2002; 87: 457–61

    Article  PubMed  CAS  Google Scholar 

Download references

Rights and permissions

Reprints and permissions

About this article

Cite this article

Inhaled corticosteroids appear to have little risk of causing adverse effects on growth, bdbone density or cortisol levels in children with asthma. Drugs Ther. Perspect 23, 21–23 (2007). https://doi.org/10.2165/00042310-200723070-00006

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00042310-200723070-00006

Search

Navigation