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Aggressive risk factor modification and pharmacological therapy are the basic steps in managing peripheral arterial disease

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References

  1. Bulmer AC, Coombes JS. Optimising exercise training in peripheral arterial disease. Sports Med 2004; 34(14): 983–1003

    Article  PubMed  Google Scholar 

  2. Aranow WS. Drug treatment of peripheral arterial disease in the elderly. Drugs Aging 2006; 23(1): 1–12

    Article  Google Scholar 

  3. Kim CK, Schmalfuss CM, Schofield RS, et al. Pharmacological treatment of patients with peripheral arterial disease. Drugs 2003; 63(7): 637–47

    Article  PubMed  CAS  Google Scholar 

  4. Antithrombotic Trialists’ Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002; 324: 71-86

    Google Scholar 

  5. Hess H, Mietaschk A, Deichsel G. Drug-induced inhibition of platelet function delays progression of peripheral occlusive arterial disease. Lancet 1985; 1: 415–9

    Article  PubMed  CAS  Google Scholar 

  6. Giansante C, Calabrese S, Fisicaro M, et al. Treatment of intermittent claudication with antiplatelet agents. [tiJ Int Med Res 1990; 18: 400–7

    Google Scholar 

  7. Goldhaber SZ, Manson JE, Stampfer MJ, et al. Low-dose aspirin and subsequent peripheral arterial surgery in the Physicians’ Health Study. Lancet 1992; 340: 143–5

    Article  PubMed  CAS  Google Scholar 

  8. CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996; 348: 1329–39

    Article  Google Scholar 

  9. Arcan JC, Blanchard J, Boissel JP, et al. Multicenter double-blind study of ticlopidine in the treatment of intermittent claudication and the prevention of its complications. Angiology 198; 39: 802–11

  10. Blanchard J, Carreras LO, Kindermans M. Results of EMATAP: a double-blind placebo-controlled multicentre trial of ticlopidine in patients with peripheral arterial disease. Nouv Rev Fr Hematol 1993; 35: 523–8

    Google Scholar 

  11. Janzon L, Bergqvist D, Boberg J, et al. Prevention of myocardial infarction and stroke in patients with intermittent claudication: effects of ticlopidine: results from STIMS, the Swedish Ticlopidine Multicentre Study. J Intern Med 1990; 227: 301–8

    Article  PubMed  CAS  Google Scholar 

  12. Bennett CL, Weinberg PD, Rozenberg-Ben-Dror K, et al. Thrombotic thrombocytopenic purpura associated with ticlopidine: a review of 60 cases. Ann Intern Med 1998; 128: 541–4

    PubMed  CAS  Google Scholar 

  13. Chew DP, Bhatt DL, Sapp S, et al. Increased mortality with oral platelet glycoprotein IIb/IIIa antagonists: a meta-analysis of phase III multicenter randomized trials. Circulation 2001; 103: 201–6

    Article  PubMed  CAS  Google Scholar 

  14. Working party on thrombolysis in the management of limb ischemia. Thrombolysis in the management of lower limb peripheral arterial occlusion: a consensus document. Am J Cardiol 1998; 81: 217–18

    Google Scholar 

  15. Dutch Bypass Oral Anticoagulants or Aspirin (BOA) Study Group. Efficacy of oral anticoagulants compared with aspirin after infrainguinal bypass surgery (the Dutch Bypass Oral Anticoagulants or Aspirin Study): a randomized trial. Lancet 2000; 355: 346–51

    Article  PubMed  Google Scholar 

  16. Smith SC Jr, Blair SN, Bonow RO, et al. A statement for healthcare professionals from the American Heart Association and the American College of Cardiology. J Am Coll Cardiol 2001; 38: 1581–3

    Article  PubMed  Google Scholar 

  17. Ostergren J, Sleight P, Dagenais G, et al. Impact of ramipril in patients with evidence of clinical or subclinical peripheral arterial disease. Eur Heart J 2004; 25: 17–24

    Article  PubMed  CAS  Google Scholar 

  18. Radack K, Deck C. β-Adrenergic blocker therapy does not worsen intermittent claudication in subjects with peripheral arterial disease: meta-analysis of randomized controlled trials. Arch Intern Med 1991; 151: 1769–76

    Article  PubMed  CAS  Google Scholar 

  19. Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20, 536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002; 360: 7–22

    Article  Google Scholar 

  20. Thompson PD, Zimet R, Forbes WP, et al. Meta-analysis of results from eight randomized, placebo-controlled trials on the effect of cilostazol on patients with intermittent claudication. Am J Cardiol 2002; 90: 1314–9

    Article  PubMed  CAS  Google Scholar 

  21. Ernst E. Chelation therapy for peripheral arterial occlusive disease: a systematic review. Circulation 1997; 96: 1031–3

    Article  PubMed  CAS  Google Scholar 

  22. Coffman JD. Vasodilator drugs in peripheral vascular disease. N Engl J Med 1979; 300: 713–7

    Article  PubMed  CAS  Google Scholar 

  23. Mohler III ER, Hiatt WR, Olin JW, et al. Treatment of intermittent claudication with beraprost sodium, an orally active prostaglandin 12 analogue: a double-blinded, randomized, controlled trial. J Am Coll Cardiol 2003; 41: 1679–86

    Article  PubMed  CAS  Google Scholar 

  24. Hiatt WR. Medical treatment of peripheral arterial disease and claudication. N Engl J Med 2001; 344: 1608–21

    Article  PubMed  CAS  Google Scholar 

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Aggressive risk factor modification and pharmacological therapy are the basic steps in managing peripheral arterial disease. Drugs Ther. Perspect 22, 17–20 (2006). https://doi.org/10.2165/00042310-200622110-00005

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