Skip to main content

Advertisement

SpringerLink
Log in

Proper paracetamol use is not problematic, but hepatotoxicity may result from overdose

  • Drug Reactions and Interactions
  • Published:
Drugs & Therapy Perspectives Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Table I

References

  1. Graham GG, Scott KF, Day RO. Tolerability of paracetamol. Drug Saf 2005; 28(3): 227–40

    Article  PubMed  CAS  Google Scholar 

  2. British national formulary. No. 49. London: The Pharmaceutical Press, 2005 Mar

  3. Lauterburg BH. Analgesics and glutathione. Am J Ther 2002; 9(3): 225–33

    Article  PubMed  Google Scholar 

  4. Roberts LJ, Morrow JD. Analgesic-antipyretic and antiinflammatory agents and drugs employed in the treatment of gout. In: Goodman and Gilman’s the pharmacological basis of therapeutics. 10th ed. New York: McGraw-Hill, 2001: 687–731

  5. Prescott LF. Therapeutic misadventure with paracetamol: fact or fiction. Am J Ther 2000; 7(2): 99–114

    Article  PubMed  CAS  Google Scholar 

  6. Dart RC, Kuffner EK, Rumack BH. Treatment of pain or fever with paracetamol (acetaminophen) in the alcoholic patient: a systematic review. Am J Ther 2000; 7(2): 123–34

    Article  PubMed  CAS  Google Scholar 

  7. Rumack BH. Acetaminophen hepatotoxicity: the first 35 years. J Toxicol Clin Toxicol 2002; 40(1): 3–20

    Article  PubMed  CAS  Google Scholar 

  8. Prescott LF. Paracetamol, alcohol and the liver. Br J Clin Pharmacol 2000; 49(4): 291–301

    Article  PubMed  CAS  Google Scholar 

  9. Manyike PT, Kharasch ED, Kalhorn TF, et al. Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation. Clin Pharmacol Ther 2000; 67(3): 275–82

    Article  PubMed  CAS  Google Scholar 

  10. Buckley NA, Srinivasan J. Should a lower treatment line be used when treating paracetamol poisoning in patients with chronic alcoholism?: a case for. Drug Saf 2002; 25(9): 619–24

    Article  PubMed  CAS  Google Scholar 

  11. Savage RL, Moller PW, Ballantyne CL, et al. Variation in the risk of peptic ulcer complications with nonsteroidal antiinflammatory drug therapy. Arthritis Rheum 1993; 36(1): 84–90

    Article  PubMed  CAS  Google Scholar 

  12. Garcia Rodriguez LA, Hernandez-Diaz S. The risk of upper gastrointestinal complications associated with nonsteroidal anti-inflammatory drugs, glucocorticoids, acetaminophen, and combinations of these agents. Arthritis Res 2001; 3(2): 98–101

    Article  PubMed  CAS  Google Scholar 

  13. Rahme E, Pettitt D, LeLorier J. Determinants and sequelae associated with utilization of acetaminophen versus traditional nonsteroidal antiinflammatory drugs in an elderly population. Arthritis Rheum 2002; 46(11): 3046–54

    Article  PubMed  CAS  Google Scholar 

  14. Signorello LB, McLaughlin JK, Lipworth L, et al. Confounding by indication in epidemiological studies of commonly used analgesics. Am J Ther 2002; 9(3): 199–204

    Article  PubMed  Google Scholar 

  15. Graham GG, Graham RI, Day RO. Comparative analgesia, cardiovascular and renal effects of celecoxib, rofecoxib and acetaminophen (paracetamol). Curr Pharm Des 2002; 8(12): 1063–75

    Article  PubMed  CAS  Google Scholar 

  16. Shaheen SO, Sterne JA, Songhurst CE, et al. Frequent paracetamol use and asthma in adults. Thorax 2000; 55(4): 266–7

    Article  PubMed  CAS  Google Scholar 

Download references

Rights and permissions

Reprints and permissions

About this article

Cite this article

Proper paracetamol use is not problematic, but hepatotoxicity may result from overdose. Drugs Ther. Perspect 21, 20–22 (2005). https://doi.org/10.2165/00042310-200521100-00007

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00042310-200521100-00007

Search

Navigation