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Careful choice of agents helps achieve safe sedation in patients with head injury

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References

  1. Urwin SC, Menon DK. Comparative tolerability of sedative agents in head-injured adults. Drug Saf 2004; 27(2): 107–33

    Article  PubMed  CAS  Google Scholar 

  2. Ott L, Young B, Phillips R, et al. Altered gastric emptying in the head-injured patient: relationship to feed intolerance. J Neurosurg 1991; 74: 738–42

    Article  PubMed  CAS  Google Scholar 

  3. McArthur CJ, Gin T, Mclaren IM, et al. Gastric emptying following brain injury: effects of choice of sedation and intracranial pressure. Intensive Care Med 1995; 21: 573–6

    Article  PubMed  CAS  Google Scholar 

  4. Kapila A, Glass PS, Jacobs JR, et al. Measured context sensitive half-times of remifentanil and alfentanil. Anesthesiology 1995; 83: 968–75

    Article  PubMed  CAS  Google Scholar 

  5. Ronan KP, Gallagher TJ, George B, et al. Comparison of propofol and midazolam for sedation in intensive care unit patients. Crit Care Med 1995; 23: 286–93

    Article  PubMed  CAS  Google Scholar 

  6. Barrientos-Vega R, Sanchez-Soria MM, Moralez-Garcia C, et al. Prolonged sedation of critically ill patients with midazolam or propofol: impact on weaning and costs. Crit Care Med 1997; 25: 33–40

    Article  PubMed  CAS  Google Scholar 

  7. Rhoney DH, Parker D. Use of sedative and analgesic agents in neurotrauma patients: effects on cerebral physiology. Neurol Res 2001; 23: 237–59

    Article  PubMed  CAS  Google Scholar 

  8. Allonen H, Ziegler G, Klotz U. Midazolam kinetics. Clin Pharmacol Ther 1981; 30: 653–61

    Article  PubMed  CAS  Google Scholar 

  9. Jacobi J, Fraser GL, Coursin DB, et al. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med 2002; 30: 119–42

    Article  PubMed  Google Scholar 

  10. Egan TD, Lemmens HJM, Fiset P, et al. The pharmacokinetics of the new short-acting opioid remifentanil (G18704B) in healthy adult male volunteers. Anesthesiology 1993: 79: 881–92

    Article  PubMed  CAS  Google Scholar 

  11. Cairns CJ, Thomas B, Fletcher S, et al. Life-threatening hyperkalemia following therapeutic barbiturate coma. Intensive Care Med 2002; 28: 1357–60

    Article  PubMed  Google Scholar 

  12. Absalom A, Pledger D, Kong A. Adrenocortical function in critically ill patients 24-hr after a single dose of etomidate. Anaesthesia 1999; 54: 861–7

    Article  PubMed  CAS  Google Scholar 

  13. Wyatt I, Ledingham IM. Mortality amongst multiple trauma patients admitted to an intensive therapy unit. Anaesthesia 1984; 39: 973–81

    Article  Google Scholar 

  14. Cohen IL, editor. The management of the agitated ICU patient. Crit Care Med 2002; 30 Suppl.: S97–S123

    Google Scholar 

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Careful choice of agents helps achieve safe sedation in patients with head injury. Drugs Ther. Perspect 21, 20–23 (2005). https://doi.org/10.2165/00042310-200521040-00007

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