References
Skirvin JA, Lichtman SM. Pharmacokinetic considerations of oral chemotherapy in elderly patients with cancer. Drugs Aging 2002; 19: 25–42
Kimmick GG, Fleming R, Buss HB, Balducci L. Cancer chemotherapy in older adults. A tolerability perspective. Drugs Aging 1997; 10: 34–49
Canal P, Chatelut E, Guichard S, et al. Practical treatment guide for dose individualisation in cancer chemotherapy. Drugs 1998; 56: 1019–38.
Mayersohn M. Special pharmacokinetic considerations in the elderly. In: Evans WE, editor. Applied pharmacokinetics: principles of therapeutic drug monitoring. 2nd ed. Vancouver: Applied Therapeutics, 1986: 244–6
Walker AH, Jaffe JM, Gunasegaram S, et al. Characterization of an allelic variant in the nifedipine-specific element of CYP3A4: ethnic distribution and implications for prostate cancer risk. Mutations in brief no. 191. Hum Mutat Online 1998; 12: 289
Masson E, Zamboni WC. Pharmacokinetic optimisation of cancer chemotherapy. Effect on outcomes. Clin Pharmacokinet 1997; 32: 324–43
Smythe M, Hoffman J, Kizy K, et al. Estimating creatinine clearance in elderly patients with low serum creatinine concentrations. Am J Hosp Pharm 1994; 51: 198–204
Balducci L, Extermann M. Cancer chemotherapy in the older patient: what the medical oncologist needs to know. Cancer 1997; 80: 1317–22
McEvoy G. AHFS 2000: drug information. Bethesda (MD): American Society of Health System Pharmacists, 2000
Hutchins LF, Unger JM, Crowley JJ, et al. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med 1999; 341: 2061–7
Physicians desk reference. 56th ed. Montvale (NJ): Medical Economics Company, 2002
Camaggi CM, Strocchi E, Carsi P, et al. Idarubicin metabolism and pharmacokinetics after intravenous and oral administration in cancer patients: a crossover study. Cancer Chemother Pharmacol 1992; 30: 307–16
Iyer L, Ratain MJ. 5-fluorouracil pharmacokinetics: causes for variability and strategies for modulation in cancer chemotherapy. Cancer Invest 1999; 17: 494–506
Aita P, Robieux I, Sorio R, et al. Pharmacokinetics of oral etoposide in patients with hepatocellular carcinoma. Cancer Chemother Pharmacol 1999; 43: 287–94
Rights and permissions
About this article
Cite this article
Oral chemotherapy in the elderly: consideration of pharmacokinetics can optimise outcomes. Drugs Ther. Perspect 18, 20–23 (2002). https://doi.org/10.2165/00042310-200218110-00007
Published:
Issue Date:
DOI: https://doi.org/10.2165/00042310-200218110-00007