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Chlorambucil is still an appropriate first-line therapy for chronic lymphocytic leukaemia

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References

  1. Hamblin TJ. Chronic lymphocytic leukaemia. Balliere’s Clin Haematol 1987; 1: 449–91

    Article  CAS  Google Scholar 

  2. Cartwright RA, Alexander FE, McKinney PA, et al. Leukaemia and lymphoma. An atlas of distribution within areas of England and Wales 1984–8. London: Leukaemia Research Fund, 1990

    Google Scholar 

  3. Kalil N, Cheson BD. Management of chronic lymphocytic leukaemia. Drugs Aging 2000 Jan; 16(1): 9–27

    Article  PubMed  CAS  Google Scholar 

  4. Hamblin TJ. Achieving optimal outcomes in chronic lymphocytic leukaemia. Drugs 2001; 61(5): 593–611

    Article  PubMed  CAS  Google Scholar 

  5. Binet J-L, Leporier M, Dighiero G, et al. A clinical staging of chronic lymphocytic leukemia. Cancer 1977; 40: 855–64

    Article  PubMed  CAS  Google Scholar 

  6. Rai KR, Sawitsky A, Cronkite ER, et al. Clinical staging of chronic lymphocytic leukemia. Blood 1977; 46: 219–34

    Google Scholar 

  7. Montserrat, Vinolas E, Reverter JC, et al. Natural history of chronic lymphocytic leukemia; on the progression and prognosis of early clinical stages. Nouv Rev Fr Hematol 1988; 30: 359–61

    PubMed  CAS  Google Scholar 

  8. British National Formulary No. 41. London: The Pharmaceutical Press, 2001 Mar

  9. Rai KR, Peterson BL, Appelbaum FR et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med 2000 Dec; 343(24): 1750–7

    Article  PubMed  CAS  Google Scholar 

  10. Jacksic B, Brugiatelli H. High dose continuous chlorambucil vs intermittent chlorambucil plus prednisolone for treatment of B CLL: IGCI CLL-01 trial. Nouv Rev Fr Hematol 1988; 30: 437–42

    Google Scholar 

  11. Spriano M, Chiurazzi F, Liso V, et al. Multicentre prospective randomized trial of fludarabine versus chlorambucil and prednisone in previously untreated patients with active B-CLL [abstract P086]. IWCLL VIII International Workshop on Chronic Lymphocytic Leukemia; 1999 Oct; Paris

  12. Cheson BD. Therapy for previously untreated chronic lymphocytic leukaemia: a re-evaluation. Semin Hematol 1998; 35: 14–21

    PubMed  CAS  Google Scholar 

  13. Hamblin TJ. Autoimmune disease and its management in CLL. In: Cheson BD, editor. Chronic lymphocytic leukemia: scientific advances and clinical developments. New York: Marcel Dekker, 2nd edition. In press

  14. Tertian G, Cartron J, Bayle C, et al. Fatal intravascular autoimmune hemolytic anaemia after fludarabine treatment for chronic lymphocytic leukemia. Hematol Cell Ther 1996; 38: 359–60

    Article  PubMed  CAS  Google Scholar 

  15. Juliusson G, Christiansen I, Hansen MM, et al. Oral cladribine as primary therapy for patients with B-cell chronic lymphocytic leukemia. J Clin Oncol 1996; 14: 2160–6

    PubMed  CAS  Google Scholar 

  16. Gribben JG, Barlett-Pandite L, Provan A, et al. Disease free status and absence of PCR detectable minimal residual disease suggests eradication of B-CLL following autologous and allogeneic BMT. Blood 1995; 86 Suppl 1: 457

    Google Scholar 

  17. Khouri IF, Keating M, Korbling M, et al. Transplant-lite: induction of graft-v-malignancy using fludarabine-based non-ablative chemotherapy and allogeneic blood progenitor cell transplantation as treatment for lymphoid malignancies. J Clin Oncol 1998; 16: 2817–24

    PubMed  CAS  Google Scholar 

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Chlorambucil is still an appropriate first-line therapy for chronic lymphocytic leukaemia. Drugs Ther. Perspect 17, 8–12 (2001). https://doi.org/10.2165/00042310-200117200-00003

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