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Retinoic acid syndrome: beware of rapidly increasing leucocyte counts in patients receiving tretinoin

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References

  1. Fenaux P, De Botton S. Retinoic acid syndrome. Recognition, prevention and management. Drug Saf 1998 Apr; 18(4): 273–9

    Article  PubMed  CAS  Google Scholar 

  2. Fenaux P, Chastang C, Sanx M, et al. ATRA followed by chemotherapy versus ATRA plus chemotherapy and the role of maintenance therapy in newly diagnosed APL: first interim results of APL93 trial [abstract]. Blood 1997; 90 Suppl. 1: 122a

    Google Scholar 

  3. Stadler M, Ganser A, Hoelzer D. Acute promyelocytic leukemia. N Engl J Med 1994; 330: 140–1

    Article  PubMed  CAS  Google Scholar 

  4. Fenaux P, Le Deley MC, Castaigne S, et al. Effect of all trans-retinoic acid in newly diagnosed acute promyelocytic leukemia: results of a multicenter randomized trial. Blood 1993; 82: 3241–9

    PubMed  CAS  Google Scholar 

  5. Kanamaru A, Takemoto Y, Tanimoto M, et al. All-trans retinoic acid for the treatment of newly diagnosed acute promyelocytic leukemia. Blood 1995; 85: 1202–6

    PubMed  CAS  Google Scholar 

  6. Vahdat L, Maslak P, Miller WH, et al. Early mortality and the retinoic acid syndrome in acute promyelocytic leukemia: impact of cytosis, low-dose chemotherapy, PML/RAR-alpha isoform, and CD13 expression in patients treated with all-trans retinoic acid. Blood 1994; 84: 3843–9

    PubMed  CAS  Google Scholar 

  7. Wiley JS, Firkin FC. Reduction of pulmonary toxicity by prednisolone prophylaxis during all-trans retinoic acid treatment of acute promyelocytic leukemia. Leukemia 1995; 9: 774–8

    PubMed  CAS  Google Scholar 

  8. Avvisati G, Lo Coco F, Diverio D, et al. Aida (all-trans retinoic acid + idarubicin) in newly diagnosed acute promyelocytic leukemia: a gruppo italiano malattie ematologiche maligne dello adulto (Gimema) pilot study. Blood 1996; 88: 1390–8

    PubMed  CAS  Google Scholar 

  9. Tallman M, Andersen J, Schiffer C, et al. All transretinoic acid in acute promyelocytic leukemia. N Engl J Med 1997; 337: 345

    Article  Google Scholar 

  10. Cortes JE, Kantarjian H, O’Brien S, et al. All-trans retinoic acid followed by chemotherapy for salvage of refractory or relapsed acute promyelocytic leukemia. Cancer 1994; 73: 2946–52

    Article  PubMed  CAS  Google Scholar 

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Retinoic acid syndrome: beware of rapidly increasing leucocyte counts in patients receiving tretinoin. Drugs Ther. Perspect 12, 13–16 (1998). https://doi.org/10.2165/00042310-199812110-00005

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