References
Noble S, Markham A. Cyclosporin. A review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (Neoral®). Drugs 1995; 50(5): 924–41
Burke JF, Pirsch JD, Ramos E, et al. Long-term efficacy and safety of cyclosporine in renal transplant recipients. N Engl J Med 1994; 331: 358–63
Almond PS, Matas A, Gillingham K, et al. Risk factors for chronic rejection in renal allograft recipients. Transplantation 1993; 55: 752–7
Kahan BD. Cyclosporine. N Engl J Med 1989; 321: 1725–38
Vonderscher J, Meinzer A. Rationale for the development of Sandimmune Neoral. Transplant Proc 1994 Oct; 26: 2925–7
Kahan BD, Dunn J, Fitts C, et al. Reduced inter- and intrasubject variability in cyclosporine pharmacokinetics in renal transplant recipients treated with a microemulsion formulation in conjunction with fasting, low-fat meals, or high-fat meals. Transplantation 1995 Feb 27; 59: 505–511
Freeman D, Grant D, Levy G, et al. Pharmacokinetics of a new oral formulation of cyclosporine in liver transplant recipients. Ther Drug Monit 1995; 17: 213–6
Frei U, Taesch S, Niese D. Use of Sandimmun Neoral in renal transplant patients. Transplant Proc 1994 Oct; 26: 2928–31 (Study in 2 parts. Pt A)
Neumayer HH, Färber L, Haller P, et al. Substitution of conventional cyclosporin with a new microemulsion formulation in renal transplant patients: results after 1 year. Nephrol Dial Transplant 1996; 11: 165–172
Pollak R. The Neora™ vs Sandimmune® soft-gelatin capsule randomized multicenter three-month double-blind trial (N-103): tolerability and safety profiles. In: Neoral™: The new Microemulsion Formulation of Cyclosporine, Special Report, May 1995. Cedar Knolls, New Jersey, USA: World Medical Press, 1995: 19–27
Niese D, on behalf of the International Sandimmun Neoral Study Group. A double-blind randomized study of Sandimmun Neoral versus Sandimmun in new renal transplant recipients: results after 12 months. Transplant Proc 1995 Apr; 27: 1849–56
Levy G, Altraif I, Rezieg M. et al. Cyclosporine Neoral in liver transplant recipients. Transplant Proc 1994 Dec; 26: 3184–7
Svendsen U, Larsen K, Allermand H, et al. Neoral conversion study: shift from Sandimmune classic formulation to Sandimmmune Neoral in heart and lung transplant patients. Transplant Proc 1995 Dec; 27: 3477
Neumayer HH. Cyclosporin as microemulsion — is it a new drug? Nephrol Dial Transplant 1996; 11: 19–20
Keown P, Lawen JG, Landsberg D, et al. Economic analysis of Sandimmune Neoral in Canada in stable renal transplant patients. Transplant Proc 1995 Apr; 27: 1845–8
Tsunoda SM and Aweeka FT. The use of therapeutic drug monitoring to optimise immunosuppressive therapy. Clin Pharmacokinet 1996 Feb; 30(2): 107–40
Friman S, Bäckman L. A new microemulsion formulation of cyclosporin. Pharmacokinetic and clinical features. Clin Pharmacokinet 1996 Mar; 30(3): 181–93
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Clear pharmacokinetic advantages with microemulsion formulation of cyclosporin. Drugs Ther. Perspect 7, 6–8 (1996). https://doi.org/10.2165/00042310-199607060-00003
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DOI: https://doi.org/10.2165/00042310-199607060-00003