Notes
The use of trade names is for product identification purposes only and does not imply endorsement.
References
Hair PI, Curran MP, Keam SJ. Tramadol extended-release tablets. Drugs 2006; 66(15): 2017–27
Davis MP. Tramadol extended-release tablets: a viewpoint. Drugs 2006; 66(15): 2028
Sachs CJ. Tramadol extended-release tablets: a viewpoint. Drugs 2006; 66(15): 2028–9
McCarberg BH. Tramadol extended-release tablets: a viewpoint. Drugs 2006; 66(15): 2029–30
Best Practice Committee of the Health Care Association of New Jersey. Hamilton (NJ). Pain management guideline [online]. Available from URL: http://www.hcanj.org/docs/hcanjbp_painmgmt2.pdf [Accessed 2006 Oct 4]
Wisconsin Medical Society Task Force on Pain Management. Guidelines for the assessment and management of chronic pain. Wis Med J 2004; 103(3): 15–42
ULTRAM® (Tramadol hydrochloride tablets). US prescribing information May 2004. Raritan (NJ): Ortho-McNeil Pharmaceutical Inc. [online]. Available from URL: http://www.onhomcneil.com [Accessed 2006 Oct 2]
Grond S, Sablotzki A. Clinical pharmacology of tramadol. Clin Pharmacokinet 2004; 43(13): 879–923
Keating GM. Tramadol sustained-release capsules. Drugs 2006; 66(2): 223–30
Mattia C, Coluzzi F. Once-daily tramadol in rheumatological pain. Expert Opin Pharmacother 2006; 7(13): 1811–23
ULTRAM® ER (tramadol HC1) extended-release tablets: an oral once-daily formulation of tramadol. Formulary 2006 Sep; 41 Suppl.: 1-17
Biovail Corporation. Investor conference: June 28, 2005 [online]. Available from URL: http://www.biovail.com/local/ files/Commercial%20Operations.pdf [Accessed 2006 Sep 29]
Modified release formulations of at least one form of tramadol. United States patent application: 20060099249. Kind code: A1. Inventors: Seth, Pawan, et al. May 11, 2006 [online]. Available from URL: http://www.uspto.gov [Accessed 2006 Oct 1]
Biovail Corporation. Biovail Corp International 20-F for 12/31/ 05 [online]. Available from URL: http://www.secinfo.com/dVut2.v49s.htm [Accessed 2006 Sep 24]
ULTRAM® ER (Tramadol HCl) extended-release tablets. US prescribing information January 2006. Raritan (NJ): Ortho-McNeil Inc. [online]. Available from URL: http://www.orthomcneil.com [Accessed 2006 Oct 2]
Lai JC, Sista S, Eradiri O, et al. The pharmacokinetics of novel once daily tramadol hydrochloride extended release tablets in healthy subjects [abstract no. M1071]. AAPS PharmSci 2003; 5 Suppl. 1. Plus poster presented at the Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists; 2003 Oct 26–30; Salt Lake City (UT)
Eradiri O, Sista S, Lai JC-K, et al. Bioavailability of extended-release and immediate-release formulations of tramadol HCl [abstract no. 126]. J Clin Pharmacol 2006; 46(9): 1091. Plus poster presented at the 35th Annual Meeting of the American College of Clinical Pharmacology; 2006 Sep 17–19; Cambridge (MA)
Babul N, Noveck R, Chipman H, et al. Efficacy and safety of extended-release, once-daily tramadol in chronic pain: a randomized 12-week clinical trial in osteoarthritis of the knee. J Pain Symptom Manage 2004; 28(1): 59–71
Gana TJ, Pascual MLG, Fleming RRB, et al. Extended-release tramadol in the treatment of osteoarthritis: a multicenter, randomized, double-blind, placebo-controlled clinical trial. 023 Study Group. Curr Med Res Opin 2006; 22(7): 1391–401
Pedersen RS, Damkier P, Brosen K. Enantioselective pharma-cokinetics of tramadol in CYP2D6 extensive and poor metabolizers. Eur J Clin Pharmacol 2006; 62(7): 513–21
Ide S, Minami M, Ishihara K, et al. Mu opioid receptor-dependent and independent components in effects of tramadol. Neuropharmacology 2006; 51(3): 651–8
Enggaard TP, Poulsen L, Arendt-Nielsen L, et al. The analgesic effect of tramadol after intravenous injection in healthy volunteers in relation to CYP2D6. Anesth Analg 2006; 102(1): 146–50
Vestergaard P, Rejnmark L, Mosekilde L. Fracture risk associated with the use of morphine and opiates. J Intern Med 2006; 260(1): 76–87
Barann M, Urban B, Stamer U, et al. Effects of tramadol and Odemethyl-tramadol on human 5-HT reuptake carriers and human 5-HT3A receptors: a possible mechanism for tramadol-induced early emesis. Eur J Pharmacol 2006; 531(1–3): 54–8
Cepeda MS, Camargo F, Zea C, et al. Tramadol for osteoarthritis. Cochrane Database Syst Rev 2006 Jul 19; 3: CD005522
Cepeda MS, Africano JM, Polo R, et al. What decline in pain intensity is meaningful to patients with acute pain? Pain 2003; 105(1–2): 151–7
Gallagher EJ, Liebman M, Bijur PE. Prospective validation of clinically important changes in pain severity measured on a visual analog scale. Ann Emerg Med 2001; 38(6): 633–8
Bianchi M, Broggini M, Balzarini P, et al. Effects of tramadol on synovial fluid concentrations of substance P and interleukin-6 in patients with knee osteoarthritis: comparison with paracetamol. Int Immunopharmacol 2003; 3(13–14): 1901–8
American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. Arthritis Rheum 2000; 43(9): 1905–15
Hudson L, Richard H, Pilote L. Differences in outcomes of patients with congestive heart failure prescribed celecoxib, rofecoxib or non-steroidal anti-inflammatory drugs: population based study. BMJ 2005 Jun 11; 330(7504): 1370
Caldwell B, Aldington S, Weatherall M, et al. Risk of cardiovascular events and celecoxib: a systematic review and meta-analysis. J R Soc Med 2006; 99(3): 132–40
National Pharmaceutical Council, Inc., Joint Commission on Accreditation of Healthcare Organizations. Pain: current understanding of assessment, management, and treatments. Reston (VA): National Pharmaceutical Council, Inc., 2001 [online]. Available from URL: http://www.npcnow.org/resources/PDFs/painmonograph.pdf [Accessed 2006 Sep 26]
Weinstein SM, Laux LF, Thornby JI, et al. Physicians’ attitudes toward pain and the use of opioid analgesics: results of a survey from the Texas Cancer Pain Initiative. South Med J 2000; 93(5): 479–87
Acknowledgement
Dr Davis has no conflicts of interest directly relevant to the content of this commentary.
Dr Sachs has no conflicts of interest directly relevant to the content of this commentary.
Dr McCarberg has no conflicts of interest directly relevant to the content of this commentary.
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Adapted and reproduced from Drugs 2006; 66 (15): 2017-30.[1–4] The manufacturer of the agent under review was offered an opportunity to comment on the original article[1] during the peer review process; changes based on any comments received were made on the basis of scientific and editorial merit.
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Hair, P.I., Curran, M.P. & Keam, S.J. Tramadol Extended-Release Tablets in Moderate to Moderately Severe Chronic Pain in Adults. CNS Drugs 21, 259–263 (2007). https://doi.org/10.2165/00023210-200721030-00005
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DOI: https://doi.org/10.2165/00023210-200721030-00005