Abstract
Acid inhibition is safe and useful in several clinical settings. Proton pump inhibitors are more effective than H2-receptor antagonists in virtually all cases. Proton pump inhibitors should be used in: the eradication of Helicobacter pylori; the treatment of non-H. pylori-related peptic ulcer healing; for the prevention and treatment of non-steroidal anti-inflammatory drug-induced upper digestive lesions; for bleeding peptic lesions; and, especially, in the short-term and long-term control of gastro-oesophageal reflux disease. The timing, the dosing and the specific drugs should be adapted to the particular patient, clinical situation and local factors. For instance, in a patient with active bleeding from a duodenal ulcer, intravenous constant infusion should be the preferred treatment. When seeking oral ‘potent’ acid inhibition (refractory gastro-oesophageal reflux disease, and perhaps Barrett’s oesophagus), available data suggest that the pharmacological and clinical profiles of esomeprazole are slightly better.
Similar content being viewed by others
References
Marzo M, Alonso P, Bonfill X, et al. Guía de Práctica Clínica. Manejo del paciente con enfermedad por reflujo gastroesofágico (ERGE). Gastroenterol Hepatol 2002; 25: 85–110
Mascort JJ, Marzo M, Alonso-Coello P, et al. Guía de Práctica Clínica sobre el manejo del paciente con dispepsia. Gastroenterol Hepatol 2003; 26: 571–613
Burget DW, Chiverton SG, Hunt RH. Is there an optimal degree of acid suppression for healing of duodenal ulcers? A model of the relationship between ulcer healing and acid suppression. Gastroenterology 1990; 99: 345–51
Chiba N, De Gara CJ, Wilkinson JM, et al. Speed of healing and symptom relief in grade II to IV gastroesophageal reflux disease: a meta-analysis. Gastroenterology 1997; 112: 1798–810
Klikenberg-Knol EC, Festen HPM, Jansen JBMJ, et al. Long-term treatment with omeprazole for refractory reflux esophagitis: efficacy and safety. Ann Intern Med 1994; 121: 161–7
Bateman DN, Colin-Jones D, Hartz S, et al. Mortality study of 18000 patients treated with omeprazole. Gut 2003; 52: 942–6
Bamberg P, Caswell CM, Frame MH, et al. A meta-analysis comparing the efficacy of omeprazole with H2-receptor antagonists for acute treatment of duodenal ulcer in Asian patients. J Gastroenterol Hepatol 1992; 7: 577–85
Eriksson S, Langstrom G, Rikner L, et al. Omeprazole and H2-receptor antagonists in the acute treatment of duodenal ulcer, gastric ulcer and reflux oesophagitis: a meta-analysis. Eur J Gastroenterol Hepatol 1995; 7: 467–75
Gisbert JP, Gonzalez L, Calvet X, et al. Proton pump inhibitors versus H2-antagonists: a meta-analysis of their efficacy in treating bleeding peptic ulcer. Aliment Pharmacol Ther 2001; 15: 917–26
Gisbert JP, Khorrami S, Calvet X, et al. Meta-analysis: proton pump inhibitors vs. H2-receptor antagonists -their efficacy with antibiotics in H. pylori eradication. Aliment Pharmacol Ther 2003; 18: 757–66
Poynard T, Lemaire M, Agostini H. Meta-analysis of randomized clinical trials comparing lansoprazole with ranitidine or famotidine in the treatment of acute duodenal ulcer. Eur J Gastroenterol Hepatol 1995; 7: 661–5
Vallve M, Vergara M, Gisbert JP, et al. Single vs. double dose of a proton pump inhibitor in triple therapy for H. pylori eradication: a meta-analysis. Aliment Pharmacol Ther 2002; 16: 1149–56
Forman D, Bazzoli F, Bennett C, et al. Therapies for the eradication of H. pylori (Protocol for the Cochrane Review). Available in The Cochrane Library [database on disk and CD ROM]. Updated quarterly. The Cochrane Collaboration; Issue 4. Oxford: Oxford Update Software, 2002.
Gisbert JP, Calvet X, Gomollón F, et al. Conferencia de consenso. Tratamiento erradicador de H. pylori. Reco-mendaciones de la Conferencia Española de Consenso. Med Clin (Barc) 2000; 114: 185–95
Vergara M, Vallve M, Gisbert JP, et al. Meta-analysis: comparative efficacy of different proton-pump inhibitors in triple therapy for H. pylori eradication. Aliment Pharmacol Ther 2003; 18: 647–54
Lanas A, Remacha B, Sáinz S, et al. Study of outcome after targeted intervention for peptic ulcer resistant to acid suppression therapy. Am J Gastroenterol 2000; 95: 513–9
Valenzuela JE, Kogut DG, McCullough AJ, et al. Comparison of once-daily doses of omeprazole (40 and 20 mg) and placebo in the treatment of benign gastric ulcer: a multicenter, randomized, double-blind study. Am J Gastroenterol 1996; 91: 2516–22
Silverstein FE, Graham DY, Senior JR, et al. Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 1995; 123: 241–9
Lanas A, Piqué JM, Ponce J. Estrategia clínica para el paciente que precisa antiinflamatorios no esteroides: posición de los inhibidores de la COX-2. Gastroenterol Hepatol 2001; 24: 22–36
Lanas A, Rodrigo L, Márquez JL, et al. Low frequency of upper gastrointestinal complications in a cohort of high-risk patients taking low-dose aspirin or NSAIDS and omeprazole. Scand J Gastroenterol 2003; 38: 693–700
Lanas A, Martín-Mola E, Ponce J, et al. Estrategia clínica para la prevención de los efectos adversos sobre el tracto digestivo de los antiinflamatorios no esteroideos. Recomendaciones de la Asociación Española de Gastroenter-ología y de la Sociedad Española de Reumatología. Gastroenterol Hepatol 2003; 26: 485–502
Barkun A, Bardou M, Marshall JK. Consensus Recommendations for Managing Patients with Nonvariceal Upper Gastrointestinal Bleeding. Ann Intern Med 2003; 139: 843–57
Sung JJY, Chan FL, Lau JYW, et al. The effect of endoscopic therapy in patients receiving omeprazole for bleeding ulcers with nonbleeding visible vessels or adherent clots. A randomized comparison. Ann Intern Med 2003; 139: 237–43
Khuroo MS, Yatoo GN, Javid G, et al. A comparison of omeprazole and placebo for bleeding peptic ulcer. N Engl J Med 1997; 336: 1054–8
Kaviani MJ, Hashemi MR, Kazemifar AR, et al. Effect of oral omeprazole in reducing rebleeding in bleeding peptic ulcers: a prospective, double-blind, randomized, clinical trial. Aliment Pharmacol Ther 2003; 17: 211–6
Gisbert JP, González L, Calvet X, et al. Proton-pump inhibitors versus H2-antagonists: a meta-analysis of their efficacy in treating bleeding peptic ulcer. Aliment Pharmacol Ther 2001; 15: 917–26
Zed PJ, Loewen PS, Slavik RS, et al. Meta-analysis of proton-pump inhibitors in treatment of bleeding peptic ulcers. Ann Pharmacother 2001; 35: 1528–34
Dean BB, Gano AD, Knight K, et al. Effectiveness of proton pump inhibitors in nonerosive reflux disease. Clin Gastroenterol Hepatol 2004; 2: 656–64
Leite LP, Johnston BT, Just RJ, et al. Persistent acid secretion during omeprazole therapy: a study of gastric acid profiles in patients demonstrating failure of omeprazole therapy. Am J Gastroenterol 1996; 91: 1527–31
Vakil N, Fennerty MB. Systematic review: direct comparative trials of the efficacy of proton pump inhibitors in the management of gastro-esophageal reflux disease and peptic ulcer disease. Aliment Pharmacol Ther 2003; 18: 559–68
Tutuian R, Katz PO, Castell DO. Nocturnal acid breakthrough: pH, drugs and bugs. Eur J Gastroenterol Hepatol 2004; 16: 441–3
Ours TM, Fackler WK, Richter JE, et al. Nocturnal acid breakthrough: clinical significance and correlation with esophageal acid exposure. Am J Gastroenterol 2003; 98: 545–50
Omeprazole. Available from URL: http://www.drugs.com/MMX/Omeprazole_Magnesium.html#citec00147746. [Accessed February 5 2001]
Protonix1 (Wyeth-Ayerst) (pantoprazole sodium) Delayed-Release Tablets. Available from URL: http://www.drugs.com/xq/cfm/pageID_0/htm_90406395.htm/type_PDR/bn_PANTOPRAZOLE%20SODIUM/qx/index.htm. [Accessed October 7 2002]
Prevacid® (lansoprazole) Delayed-Release Capsules. Available from URL: http://www.drugs.com/xq/cfm/pageID_0/htm_81001100.htm/type_PDR/bn_LANSOP-RAZOLE/qx/index.htm [Accessed July 1 2002]
Aciphex1 (Eisai) (rabeprazole sodium) Delayed-Release Tablets. Available from URL: http://www.drugs.com//xq/cfm/pageid_0/htm_25750200.htm/tgid_/bn_RABEP-RAZOLE%20SODIUM/type_pdr/qx/index.htm [Accessed January 11 2002]
Nexium® (AstraZeneca LP) (esomeprazole magnesium) delayed release capsules. Available from URL: http://www.drugs.com//xq/cfm/pageid_0/htm_04002180.htm/tgid_/bn_ESOMEPRAZOLE%20MAGNESIUM/type_pdr/qx/index.htm [Accessed January 2 2003]
Mansfield P, Henry D, Tonkin A. Single-enantiomer drugs: elegant science, disappointing effects. Clin Pharmacokinet 2004; 43: 287–90
Andersson T. Single-enantiomer drugs: true therapeutic advances. Clin Pharmacokinet 2004; 43: 279–85
Thompson PD, Clarkson P, Karas RH. Statin-associated myopathy. JAMA 2003; 289: 1681–90
Pilote L, Abrahamowicz M, Rodrigues E, et al. Mortality rates in elderly patients who take different angiotensin-converting enzyme inhibitors after acute myocardial infarction: a class effect? Ann Intern Med 2004; 141: 102–12
Tinmouth JM, Steele LS, Tomlinson G, et al. Are claims of equivalency in digestive disease trials supported by the evidence? Gastroenterology 2004; 126: 1700–10
Navarro MA, Raei N, Torres F, et al. Differences in the release of omeprazole in 4 commercial preparations: influence of pH and ionic concentration [in Spanish]. Gastroenterol Hepatol 1998; 21: 63–70
Fass R, Thomas S, Traxler B, et al. Patient reported outcome of heartburn improvement: doubling the proton pump inhibitor (PPI) dose in patients who failed standard dose PPI versus switching to a different PPI. Gastroenterology 2004; 1264 Suppl 2: A326
McCarthy DM, McLaughlin TP, Griffis DL, et al. Impact of cotherapy with some proton pump inhibitors on medical claims among HMO patients already using other common drugs also cleared by cythochrome P450. Am J Ther 2003; 10: 330–40
Labenz J, Petersen KU, Rosch W, et al. A summary of Food and Drug Administration-reported adverse events and drug interactions occuring during therapy with omeprazole, lansoprazole, and pantoprazole. Aliment Pharmacol Ther 2003; 17: 1015–9
Hatlebak JG, Katz PO, Camacho-Lobato L, et al. Protonpump inhibitors: better acid suppression when taken before a meal than without a meal. Aliment Pharmacol Ther 2000; 14: 1267–72
Mussig S, Witzel L, Luhmann R, et al. Morning and evening administration of pantoprazole: a study to compare the effect on 24-hour intragastric pH. Eur J Gastroenterol Hepatol 1997; 9: 599–602
Fraser AG, Sawyerr AM, Hudson M, et al. Morning versus evening dosing of lansoprazole 30 mg daily on twenty-four-hour intragastric acidity in healthy subjects. Aliment Pharmacol Ther 1996; 10: 523–7
Chiverton SG, Howden CW, Burget DW, et al. Omeprazole (20 mg) daily given in the morning or evening: a comparison of effects on gastric acidity, and plasma gastrin and omeprazole concentration. Aliment Pharmacol Ther 1992; 6: 103–11
Hatlebakk JG, Katz PO, Kuo B, et al. Nocturnal gastric acidity and acid breakthrough on different regimens of omeprazole 40 mg daily. Aliment Pharmacol Ther 1998; 12: 1235–40
Huang JQ, Hunt RH. Pharmacological and pharmacody-namic essentials of H(2)-receptor antagonists and proton pump inhibitors for the practising physician. Best Pract Res Clin Gastroenterol 2001; 15: 355–70
Hammer J, Schmidt B. Effect of splitting the dose of esomeprazole on gastric acidity and nocturnal acid breakthrough. Aliment Pharmacol Ther 2004; 19: 1–6
Yeh RW, Gerson LB, Triadafilopoulos G. Efficacy of esomeprazole in controlling reflux sympton intraesophageal, and intragastric pH in patients with Barrett’s esophagus. Dis Esophagus 2003; 16: 193–8
Spechler SJ. Are we underestimating acid reflux? Gut 2004; 53: 162–3
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Gomollón, F., Calvet, X. Optimising Acid Inhibition Treatment. Drugs 65 (Suppl 1), 25–33 (2005). https://doi.org/10.2165/00003495-200565001-00005
Published:
Issue Date:
DOI: https://doi.org/10.2165/00003495-200565001-00005