Abstract
The most essential kinases involved in cell membrane receptor activation, signal transduction and cell cycle control or programmed cell death and their interconections are reviewed. In tumours, the genes of many of those kinases are mutated or amplified or the proteins are overexpressed.
The use of key kinases offers the possibility to screen in vitro for synthetic small molecule kinase inhibitors. In view of the many interconnections of cellular kinases, their role in preventing or inducing programmed cell death and the possibility that a considerable number of signal transducing proteins are still unknown, cellular test systems are recommended in which the respective key kinase or one of its main partner molecules are overexpressed.
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Acknowledgements
The author is indepted to Professor Rolf Müller, Institute for Molecular Biology and Tumour Research, University of Marburg, with whom he intensively discussed the network of cell signal transduction, cellular screening systems for cytostatics and the possibility of improving the present test systems for kinase inhibitors and who thereby considerable contributed to this review.
In addition, the author thanks Ms Manuela Rogala for her skilful secretarial assistance in preparing the manuscript.
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Sedlacek, H.H. Kinase Inhibitors in Cancer Therapy. Drugs 59, 435–476 (2000). https://doi.org/10.2165/00003495-200059030-00004
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DOI: https://doi.org/10.2165/00003495-200059030-00004