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The Effect of Nimesulide on Prostanoid Formation

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Summary

Nimesulide (4-nitro-2-phenoxy-methansulfonanilide) is a weak acidic (pKa = 6.50) nonsteroidal anti-inflammatory drug (NSAID) belonging to a new chemical class, the sulfonanilide derivatives, and does not contain the carboxylic group. It exhibits potent anti-inflammatory, analgesic and antipyretic activities. Although nimesulide is not a cyclo-oxygenase inhibitor in gastric tissues or bovine seminal vesicle microsomes, it inhibits prostaglandin synthesis in zymosan-stimulated murine macrophages in inflammatory exudate. Nimesulide significantly antagonises the immune formation of thromboxane B2 in lung tissue. It neither induces gastrointestinal lesions nor affects renal function in animal models.

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  1. Department of Scientific Affairs, Helsinn Healthcare SA, Via Livio 14, CH — 6830, Chiasso, Switzerland

    E. Magni

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  1. E. Magni
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Magni, E. The Effect of Nimesulide on Prostanoid Formation. Drugs 46 (Suppl 1), 10–14 (1993). https://doi.org/10.2165/00003495-199300461-00004

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