Summary
Adverse effects on serum triglycerides and cholesterol fractions have been reported in hypertensive patients treated with diuretics and non-selective β-blockers. However, the changes induced by cardioselective β-blockers and those with intrinsic sympathomimetic activity (ISA) or by α-blockers have been shown to be more favourable. In addition, evidence suggests that calcium antagonists and angiotensin-converting enzyme (ACE) inhibitors have little effect on serum lipid concentrations in hypertensive patients, although until now only diuretics and β-blockers without ISA have been shown to reduce morbidity and mortality.
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Amery, A., Lijnen, P. Alterations in Lipid Metabolism Induced by Antihypertensive Therapy. Drugs 36 (Suppl 2), 1–5 (1988). https://doi.org/10.2165/00003495-198800362-00002
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DOI: https://doi.org/10.2165/00003495-198800362-00002