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Sulbactam/Ampicillin in Paediatric Infections

  • Section 3: Clinical Profiles of Sulbactam/Ampicillin
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Summary

The emergence and spread of ampicillin- resisiant Haemophilus influenzae type b strains have led to a sharp reduction in the use of ampicillin, or the addition of chloramphenicol, in the initial therapy of serious childhood infections. In some instances, third generation cephalosporins are used instead.

The combination of ampicillin with sulbactam restores the former usefulness of ampicillin and extends its spectrum of activity to include normally ampicillin- resistant Staphylococcus aureus. Sulbactam/ampicillin should be useful in treating bacterial meningitis. It is more effective than third generation cephalosporins against Listeria and enterococci, and is more effective than ampicillin against Enterobacteriaceae. The combination also holds promise as a treatment for soft tissue, bone and joint infections in children.

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Authors and Affiliations

  1. Division of Infectious Diseases, Children’s Hospital of Michicgan, Wayne State University, Director, 3901 Beaubien Boulevard, Detroit, Michigan, 48201, USA

    Adnan S. Dajani (Professor of Pediatrics)

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  1. Adnan S. Dajani
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Dajani, A.S. Sulbactam/Ampicillin in Paediatric Infections. Drugs 35 (Suppl 7), 35–38 (1988). https://doi.org/10.2165/00003495-198800357-00009

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  • DOI: https://doi.org/10.2165/00003495-198800357-00009

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