Summary
Giant cell (temporal) arteritis was first described by Horton and colleagues in 1932, and polymyalgia rheumatica in 1957 by Barber who suggested this title for an entity resembling, but distinct from, rheumatoid arthritis of unknown aetiology in the elderly. Arteritic features were sufficiently common in polymyalgia rheumatica to suggest an arteriopathy as a cause, further evidence of this being the change from the clinical picture of polymyalgia rheumatica to giant cell arteritis and vice versa in many patients such that the alternative title polymyalgia arteritica was suggested. The clinical picture of polymyalgia rheumatica is that of an elderly patient, more often female than male, usually over 60 years of age, with painful stiffness in the girdle joints and muscles of the shoulders and hips, but seldom with findings in peripheral or intermediate joints. The painful stiffness in the shoulders, hips and thighs is worse in the early morning. An erythrocyte sedimentation rate over 50mm in 1 hour is usual, and there is a rapid and dramatic response to small doses of corticosteroids (around 10mg prednisolone daily). Arteritic and axial arthritic features have been noted by different authors in different ratios, the disorder gradually abating naturally over periods varying from several months to 7 to 10 years. Deaths, when they occur in this elderly group of patients, have usually been unrelated to the disease or its treatment, but osteoporotic vertebral crush fractures are not uncommon. Partial or complete blindness may occur in patients with either giant cell arteritis or polymyalgia rheumatica, often appearing rapidly after cessation of corticosteroid therapy or rapid reduction of dosage.
While non-steroidal anti-inflammatory agents (NSAIDs) are sufficient treatment in mild cases presenting with no arterial features, corticosteroids in conservative doses (around 10mg prednisolone daily initially) are much more rapidly and completely effective. A higher dosage of 20 to 30mg daily is needed initially in those with an arteritic picture and where vision is threatened, 50mg daily or possibly more is needed.
Polymyalgia rheumatica was previously diagnosed infrequently and many elderly patients suffered unnecessarily. While this still occurs today, many patients are being treated for prolonged periods on corticosteroids where these drugs are probably unnecessary and simple analgesics or NSAIDs would suffice. In the absence of a diagnostic test other than arterial biopsy, diagnosis rests on clinical judgement and treatment is necessarily empirical.
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References
Al-Hussaini AS, Swannell AJ. Peripheral joint involvement in polymyalgia rheumatica. British Journal of Rheumatology 24: 27–30, 1985
Alestig K, Barr J. Giant cell arteritis: a biopsy study of polymyalgia rheumatica. Lancet 1: 1228–1230, 1963
Bagratuni L. A rheumatoid syndrome occurring in the elderly. Annals of the Rheumatic Diseases 12: 98–104, 1953
Barber HS. Myalgic syndrome with constitutional effects: polymyalgia rheumatica. Annals of the Rheumatic Diseases 16: 230–237, 1957
Behn AR, Perera T, Myles AB. Polymyalgia rheumatica and corticosteroids: how much for how long? Annals of the Rheumatic Diseases 42: 374–378, 1983
Bengtsson BA, Malmvall BE. The epidemiology of giant cell arteritis including temporal arteritis and polymyalgia rheumatica. Arthritis and Rheumatism 24: 899–904, 1981
Bird HA, Esselinckx W, Dixon AStJ, Mowat AG, Wood PNH. An evaluation of criteria for polymyalgia rheumatica. Annals of the Rheumatic Diseases 38: 434–439, 1979
Bruce W. Senile rheumatic gout. British Medical Journal 2: 811–813, 1888
Bruk MI. Articular and vascular manifestations of polymyalgia rheumatica. Annals of the Rheumatic Diseases 26: 103–116, 1967
Coomes EN, Sharp J. Polymyalgia rheumatica — a misnomer? Lancet 2: 1328–1331, 1961
Dixon AJ, Beardwell C, Kay A, Wanka J, Wong YT. Polymyalgia rheumatica and temporal arteritis. Annals of the Rheumatic Diseases 25: 203–208, 1966
Douglas WAC, Martin BA, Morris JH. Polymyalgia rheumatica: an arthroscopic study of the shoulder joint. Annals of the Rheumatic Diseases 42: 311–316, 1983
Gordon I. Polymyalgia rheumatica: a clinical study of 21 cases. Quarterly Journal of Medicine 29: 473–488, 1960
Hamilton CR, Shelley WM, Tumulty PA. GCA: Giant cell arteritis: including temporal arteritis and polymyalgia rheumatica. Medicine (Baltimore) 50: 1–27, 1971
Hall S, Lie JT, Kurland LT, Persellin S, O’Brien PC, et al. The therapeutic impact of temporal artery biopsy. Lancet 2: 1217–1220, 1983
Hamrin B, Jonsson N, Landberg T. Arteritis in polymyalgia rheumatica. Lancet 1: 397–399, 1964
Hamrin B, Jonsson N, Landberg T. Involvement of large vessels in polymyalgia rheumatica. Lancet 1: 1193–1195, 1965
Hart FD. Visual complications of polymyalgia rheumatica (polymyalgia arteritica). Practitioner 215: 763–766, 1975
Hart FD. Polymyalgia arteritica (polymyalgia rheumatica). In Hart (Ed.) Drug treatment of the rheumatic diseases, 2nd ed., pp. 156–158, ADIS Press, Sydney, 1982
Horton BT, Magath TB, Brown GE. An undescribed form of arteritis of the temporal vessels. Mayo Clinic Proceedings 7: 700–701, 1932
Jones JG, Hazleman BL. Prognosis and management of polymyalgia rheumatica. Annals of the Rheumatic Diseases 40: 1–5, 1981
Kersley GD. A myalgic syndrome of the aged with systemic reaction. Proceedings of the 11th Congress of European Rheumatology, Barcelona, pp. 388–389, 1951
Kinmont PDC, McCallum DI. Aetiology, pathology and course of giant cell arteritis. British Journal of Dermatology 77: 193–202, 1965
Klein RG, Campbell RJ, Hunder GG, Carney JA. Ship lesions in temporal arteritis. Mayo Clinic Proceedings 51: 504–510, 1976
Myles AB. Polymyalgia rheumatica and giant cell arteritis: a seven year survey. Rheumatology and Rehabilitation 14: 231–236, 1975
Myles AB. Corticosteroid treatment in rheumatoid arthritis. British Journal of Rheumatology 24: 125–127, 1985
O’Duffy JD, Hunder GG, Wahner HW. A follow up study of polymyalgia rheumatica: evidence of chronic axial synovitis. Journal of Rheumatology 7: 685–693, 1980
Paice EW, Wright FW, Hill AGS. Sternoclavicular erosions in polymyalgia rheumatica. Annals of the Rheumatic Diseases 42: 379–383, 1983
Park JR, Jones JG, Hazleman BL. Relationship of the erythrocyte sedimentation rate to acute phase proteins in polymyalgia rheumatic and giant cell arteritis. Annals of the Rheumatic Diseases 40: 493–495, 1981
Paulley JW, Hughes JP. Giant cell arteritis or arteritis of the aged. British Medical Journal 2: 1562–1567, 1960
Sharland DE. The erythrocyte sedimentation rate: the normal range in the elderly. Journal of the American Geriatrics Society 28: 346–348, 1980
Silman AJ, Currey HLF. Polymyalgia rheumatica in a defined elderly community. Rheumatology and Rehabilitation 21: 235–237, 1982
Wilske KR, Healey LA. Polymyalgia rheumatica: a manifestation of giant cell arteritis. Annals of Internal Medicine 66: 77–81, 1967
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Hart, F.D. Polymyalgia Rheumatica. Drugs 33, 280–287 (1987). https://doi.org/10.2165/00003495-198733030-00004
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DOI: https://doi.org/10.2165/00003495-198733030-00004