Summary
The frequency of isolation of Branhamella catarrhalis from sputum in a laboratory in the southern part of the Netherlands is renewed; at present 23% of positive cultures contain these organisms. Seasonal variations include a considerable reduction in frequency of isolation in the summer months. The possible role of heavy industry and air pollution is briefly discussed. Evidence for the direct pathogenicity of B. catarrhalis is presented, and although this may be considered as only circumstantial it is still convincing, particularly in acute otitis media and in acute purulent exacerbations of chronic respiratory disease. The possibility of indirect pathogenicity through β-lactamase production is discussed as is the evidence obtained by the use of several new antimicrobial agents which were subsequently shown to have been inappropriate.
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References
Anon. Branhamella catarrhalis: pathogen or opportunist? Lancet 1: 1056, 1982
Brorson JE, Axelsson A, Holm SE. Studies on Branhamella catarrhalis (Neisseria catarrhalis) with special reference to maxillary sinusitis. Scandinavian Journal of Infectious Diseases 8: 151–155, 1976
Coffey Jr JD. Otitis media in the practice of pediatrics. Pediatrics 38: 25, 1966
Davies BI. The epidemiology of respiratory infections in the Netherlands. In van Boven (Ed.) International symposium on the treatment of respiratory tract associated infections. In press, Excerpta Medica, Amsterdam, 1986
Davies BI, Maesen FPV. The diagnosis and treatment of respiratory infections. In Brumfitt and Hamilton-Miller (Eds) A clinical approach to progress in infectious diseases, pp. 132–158, Oxford University Press, Oxford, 1983
Davies BI, Maesen FPV, Teengs JP. Aztreonam in patients with acute purulent exacerbations of chronic bronchitis: failure to prevent emergence of pneumococcal infections. Journal of Antimicrobial Chemotherapy 15: 375–384, 1985
Diamond LA, Lorber B. Branhamella catarrhalis pneumonia and immunoglobulin abnormalities: a new association. American Reviews of Respiratory Diseases 129: 876–878, 1984
Johnson MA, Drew WL, Roberts M. Branhamella (Neisseria) catarrhalis: a lower respiratory tract pathogen. Journal of Clinical Microbiology 13: 1066–1069, 1981
Kamme C. Evaluation of the in vitro sensitivity of Neisseria catarrhalis to antibiotics with respect to acute otitis media. Scandinavian Journal of Infectious Diseases 2: 117–120, 1970
Kamme C, Lundgren K, Mårdh PA. The aetiology of acute otitis media in children. Scandinavian Journal of Infectious Diseases 3: 217, 1971
Kovatch AL, Wald ER, Michaels RH. β-Lactamase producing Branhamella catarrhalis causing otitis media in children. Journal of Pediatrics 102: 261–264, 1983
Le Faou A, Rio A. Branhamella catarrhalis en pathologie infectieuse des voies aériennes. Presse Médicale 12: 2035–2037, 1983
Leinonen M, Luotonen J, Herva E, Valkonen K, Mäkelä PH. Preliminary serologic evidence for a pathogenic role of Branhamella catarrhalis. Journal of Infectious Diseases 144: 570–574, 1981
Maesen FPV, Davies BI, Brouwers J, Salemans T. Is treatment of acute exacerbations of chronic bronchitis with intramuscular mezlocillin justifiable? Journal of Antimicrobial Chemotherapy 12: 169–173, 1983a
Maesen FPV, Davies BI, Brouwers J, Salemans T, Nelissen-Wamper M. Latamoxef (moxalactam) in acute exacerbations of chronic bronchitis. Journal of Antimicrobial Chemotherapy 11: 115–123, 1983b
Maesen FPV, Davies BI, Teengs JP. Ceftriaxone in acute purulent exacerbations of chronic bronchitis. Journal of Antimicrobial Chemotherapy 14: 653–660, 1984a
Maesen FPV, Davies BI, van Noord JA, Salemans T. Brodimoprim in acute exacerbations of chronic bronchitis: a clinical and bacteriological pilot study. Journal of Antimicrobial Chemotherapy 13: 299–300, 1984b
Maesen FPV, Davies BI, Teengs JP. Pefloxacin in acute exacerbations of chronic bronchitis. Journal of Antimicrobial Chemotherapy 16: 379–388, 1985
Malmvall BE, Brorson JE, Johnsson J. In vitro sensitivity to penicillin V and β-lactamase production of Branhamella catarrhalis. Journal of Antimicrobial Chemotherapy 3: 374–375, 1977
McLeod DT, Ahmad F, Power JT, Calder MA, Seaton A. Bronchopulmonary infection due to Branhamella catarrhalis. British Medical Journal 287: 1446–1447, 1983
Mulder J, Goslings WRO, van der Plas MC, Lopez Cardozo P. Studies on the treatment with antibacterial drugs of acute and chronic bronchitis caused by Haemophilus influenzae. Acta Medica Scandinavica 143: 32–49, 1952
Ninane G, Joly J, Piot P, Kraytman M. Branhamella (Neisseria) catarrhalis as pathogen. Lancet 2: 149, 1977
Ninane G, Joly J, Kraytman M. Bronchopulmonary infection due to Branhamella catarrhalis: 11 cases assessed by transtracheal puncture. British Medical Journal 1: 276–278, 1978
O’Callaghan CH, Morris A, Kirby SM, Shingler AH. Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate. Antimicrobial Agents and Chemotherapy 1: 283–288, 1972
Percival A, Corkill JE, Rowlands J, Sykes RB. Pathogenicity of and β-lactamase production by Branhamella (Neisseria) catarrhalis. Lancet 2: 1175, 1977
Shurin PA, Marchant CD, Kim CH, Van Hare GF, Johnson CE, et al. Emergence of beta-lactamase producing strains of Branhamella catarrhalis as important agents of acute otitis media. Pediatric Infectious Disease 2: 34–38, 1983
Stobberingh EE, Davies BI, van Boven CPA. Branhamella catarrhalis: antibiotic sensitivities and β-lactamases. Journal of Antimicrobial Chemotherapy 13: 55–64, 1984
Thornley PE, Aitken J, Drennan CJ, MacVicar J, Slevin NJ. Branhamella catarrhalis infection of the lower respiratory tract: reliable diagnosis by sputum examination. British Medical Journal 285: 1537–1538, 1982
Wardle JK. Branhamella catarrhalis as an indirect pathogen. Drugs 31(Suppl. 3): 93–96, 1986
Wilson GS, Miles AA. In Topley and Wilson, Principles of bactenology and immunity, pp. 665–692, Edward Arnold, London, 1964
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Davies, B.I., Maesen, F.P.V. Epidemiological and Bacteriological Findings on Branhamella catarrhalis Respiratory Infections in The Netherlands. Drugs 31 (Suppl 3), 28–33 (1986). https://doi.org/10.2165/00003495-198600313-00008
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DOI: https://doi.org/10.2165/00003495-198600313-00008