Summary
A protein antigen — P-antigen — itcharacteristic of Branhamella catarrhalis has been described. Precipitating antibodies against this antigen occur in a majority of healthy human sera; serological evidence for a pathogenic role of B. catarrhalis is accumulating. The occurrence of complement-fixing antibodies has been demonstrated during broncho-pulmonary infection with B. catarrhalis and in maxillary sinusitis. Increases in antibody titres assessed by an enzyme-linked immunosorbent assay (ELISA) technique have been reported in children with acute otitis media. An ELISA, using purified P- antigen, for the evaluation of IgG, IgM and IgA antibodies against B. catarrhalis is being developed.
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Eliasson, I. Serological Identification of Branhamella catarrhalis . Drugs 31 (Suppl 3), 7–10 (1986). https://doi.org/10.2165/00003495-198600313-00004
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DOI: https://doi.org/10.2165/00003495-198600313-00004