Skip to main content
SpringerLink
Log in

Tiaprofenic Acid

A Review of its Pharmacological Properties and Therapeutic Efficacy in Rheumatic Diseases and Pain States

  • Drug Evaluation
  • Published:
Drugs Aims and scope Submit manuscript

Summary

Synopsis: Tiaprofenic acid1 is a new non-steroidal anti-inflammatory agent advocated for use in rheumatoid arthritis, osteoarthritis, musculoskeletal disorders, soft-tissue injuries and inflammatory conditions and acute pain of varying origin.

Published data suggest that tiaprofenic acid 600mg daily in 2 or 3 divided doses is comparable in effectiveness with aspirin, diclofenac, ibuprofen, indomethacin, naproxen, piroxicam and sulindac in the treatment of rheumatoid arthritis and osteoarthritis. More controlled clinical trials are necessary to evaluate its potential in rheumatic conditions other than rheumatoid arthritis and osteoarthritis. In controlled studies in patients with acute pain following surgery or trauma, tiaprofenic acid was more effective than placebo and as effective as aspirin and indomethacin. While tiaprofenic acid produced fewer side effects than aspirin in rheumatoid arthritis treatment, and indomethacin in the treatment of osteoarthritis, results have generally shown the short term tolerability of tiaprofenic acid to be similar to that of other non-steroidal anti-inflammatory drugs.

As no one of the non-steroidal anti-inflammatory agents is the most suitable drug for all patients requiring such therapy, tiaprofenic acid should be considered along with other drugs of this type in the therapy of arthritic conditions and of acute postoperative or post-traumatic pain.

Pharmacodynamics: In experimental animals, tiaprofenic acid has been shown to possess anti-inflammatory and analgesic activity similar to that of several other drugs used in the treatment of rheumatic diseases.

Animal studies in rats have shown that tiaprofenic acid requires higher doses than other non-steroidal anti-inflammatory drugs to produce equivalent ulcerogenic effects. Studies in man indicate that tiaprofenic acid produces less faecal blood loss than aspirin and less ulceration, haemorrhages with occult bleeding, and clinically significant gastric hyperaemia and oedema than other non-steroidal anti-inflammatory drugs.

Although tiaprofenic acid causes marked inhibition of platelet aggregation induced by collagen and arachidonic acid in vitro, it does not influence ADP-induced primary platelet aggregation in vitro or in vivo.

Tiaprofenic acid is a potent inhibitor of prostaglandin biosynthesis in vitro and in vivo, due to the inhibition of cyclo-oxygenase. In vitro studies have revealed that although tiaprofenic acid is more active than diclofenac, indomethacin and ibuprofen in inhibiting PGE2 and PGF2 synthesis, it is less potent than either diclofenac or indomethacin in inhibiting PG12 (prostacyclin) release. Tiaprofenic acid has also been shown to inhibit prostaglandin synthesis in human rheumatoid synovium.

Pharmacokinetics: Peak plasma concentrations of 19 to 26 mg/L after a 200mg dose are usually attained 40 minutes to 2 hours after oral ingestion. Food decreases both the bioavailability and peak plasma concentrations by 10% and increases the time required to reach maximum plasma concentrations. Tiaprofenic acid is 98% bound to plasma proteins and is not distributed to any appreciable extent in body water, with volumes of distribution in man ranging from 4 to 10% of bodyweight. Tiaprofenic acid diffuses well into synovial fluid where peak concentrations are attained 1 to 4 hours after oral administration. Tiaprofenic acid is retained at comparatively steady concentrations within the synovial fluid throughout a period of at least 8 hours after administration. Parent compound and metabolites are excreted in the urine in the form of acyl glucuronides, with over 60% of a dose being recovered over a 24-hour period. The half-life of elimination is about 1.5 to 2.5 hours and is independent of dose. Total clearance has been found to range from 2.6 to 6 L/hour and 1.8 to 2.2 L/hour/m2. The pharmacokinetics of tiaprofenic acid remain unchanged in patients with impaired renal function, except in cases of severe dysfunction or nephrotic syndrome which require dosage adjustments.

Therapeutic Trials: More long term and comparative studies using optimal anti-inflammatory dosages of other non-steroidal anti-inflammatory drugs are still required for the accurate determination of the relative efficacy of tiaprofenic acid against these other agents in the treatment of rheumatic disorders. However, short term therapeutic trials published to date have shown the efficacy of tiaprofenic acid 200mg thrice daily to be significantly greater than that of placebo and generally indistinguishable from that of other non-steroidal anti-inflammatory drugs in patients with active rheumatoid arthritis. Thus, no statistically significant differences could generally be detected between the therapeutic efficacy of tiaprofenic acid 600mg daily and indomethacin 75 to 150mg daily, naproxen 500mg daily, ibuprofen 1200mg daily, phenylbutazone 300mg daily, piroxicam 20mg daily or sulindac 300mg daily in the treatment of patients with rheumatoid arthritis. Tiaprofenic acid has been generally better tolerated than aspirin 3600mg daily.

In osteoarthritis, tiaprofenic acid 200mg has been shown to be statistically significantly superior to placebo in providing improvements in pain relief and joint mobility. Comparative trials with indomethacin 75 to 150mg daily have shown little difference in efficacy between the 2 drugs; however, tiaprofenic acid has caused significantly fewer side effects which have been less severe in nature. Naproxen 500mg daily and ibuprofen 1200mg daily have also shown indistinguishable clinical efficacy from that produced by tiaprofenic acid, as have diclofenac 150mg daily, piroxicam 20 to 60mg daily and sulindac 450 to 600mg daily.

There are few published data regarding the efficacy of tiaprofenic acid in rheumatic disorders other than rheumatoid arthritis and osteoarthritis. However, in controlled trials in patients with postoperative or post-traumatic pain, tiaprofenic acid 200mg thrice daily has been shown to be superior to placebo and as effective as usual analgesic doses of aspirin and indomethacin.

Further studies involving greater numbers of patients and extending over longer periods, comparing tiaprofenic acid and other commonly used non-steroidal anti-inflammatory drugs, are needed to better determine their relative efficacy and tolerance.

Side Effects: Tiaprofenic acid is generally well tolerated and compares similarly with other non-steroidal anti-inflammatory drugs used in the treatment of rheumatic diseases. Gastrointestinal disturbances have been the most frequently reported side effects, occurring minimally in some studies and in up to 12% of patients in others. The frequency of reported central nervous system disturbances has similarly varied between studies, appearing in as few as 1% or as many as 10% of patients. Patient withdrawal rates due to tiaprofenic acid intolerance are comparable to those with some other non-steroidal anti-inflammatory drugs when given under the same study conditions. Withdrawal rates due to tiaprofenic acid, ibuprofen, indomethacin, naproxen and piroxicam have been 3.7, 3.8, 7.8, 2.8 and 7.0%, respectively.

Dosage: The starting and maintenance dose of oral tiaprofenic acid is 600mg daily in 3 divided doses.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Alvarez, J.L.P.; de Vallado, P.F. and Ballarin, J.M.P.: A comparative study with tiaprofenic acid versus diclofenac in knee osteoarthritis; in Berry and Franchimont (Eds) Tiaprofenic Acid. Papers presented at the 10th European Congress of Rheumatology, Moscow 26 June to 2 July, 1983. pp. 71–76 (Excerpta Medica, Geneva 1984).

    Google Scholar 

  • Anderson, I.F.: Treatment of rheumatoid arthritis. An open evaluation of tiaprofenic acid. South African Medical Journal (Suppl.): 6–8 (29 Oct 1983).

  • Ballarin, J.M.P.; de Vallado, P.F. and Soto, J.J.M.: Tiaprofenic acid in osteoarthritis of the hip and knee; in Bianchi and Colombo (Eds) New Trends in Osteoarthritis, Part II, pp. 20–22 (Karger, Basel 1983).

    Google Scholar 

  • Beaumont, V.J.; Scott, S.M.; Greeff, O.B.W. and Steyn, H.S.: Tiaprofenic acid — a South African multicentre open evaluation in musculoskeletal disorders. South African Medical Journal (Suppl.): 9–13 (29 Oct 1983).

  • Berry, H.; Bloom, B. and Hamilton, E.B.D.: Treatment of osteoarthritis. A dose-ranging study of tiaprofenic acid (Surgam). Clinical Trials Journal 19: 217–225 (1982).

    Google Scholar 

  • Boeijinga, J.K. and Callewaert, J.A.M.: Tiaprofenic acid (Surgam®) in arthritic conditions: A randomized double-blind comparison with placebo in a multi-centre trial; in Berry and Franchimont (Eds) Tiaprofenic Acid. Papers presented at the 10th European Congress of Rheumatology, Moscow 26 June to 2 July, 1983, pp. 53–64 (Excerpta Medica, Geneva 1984).

    Google Scholar 

  • Byers, P.P.; Marondas, A. and Oztop, F.: Histological and biochemical studies on cartilage from osteoarthritic femoral heads with special reference to surface characteristics. Connective Tissue Research 5: 41–49 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Camp, A.V.: Tiaprofenic acid in the treatment of rheumatoid arthritis. Rheumatology and Rehabilitation 20: 181–183(1981).

    Article  PubMed  CAS  Google Scholar 

  • Cutting, C.J. and Thornton, E.J.: A comparative trial of tiaprolenic acid (’surgam’) versus aspirin in the control of pain following injury. Pharmatherapeutica 2: 509–512 (1981).

    PubMed  CAS  Google Scholar 

  • Davis, P.; Tannenbaum, H.; Kraag, G.; Brandwein, S.; Boate, B.; Grace, M. and Auclair, C.: Efficacy and tolerance of Surgam (tiaprofenic acid) compared to enteric-coated ASA (ECA) in rheumatoid arthritis (RA). Presented at the Third International Seminar on the Treatment of Rheumatic Diseases, Israel, 13–20 Nov (1983).

  • Daymond, T.J. and Herbert, R.: Pharmacokinetic studies of tiaprofenic acid in patients suffering from rheumatoid arthritis. Annals of the Rheumatic Diseases 40: 622 (1981).

    Google Scholar 

  • Daymond, T.J. and Herbert, R.: Simultaneous bioavailability of tiaprofenic acid (Surgam) in serum and synovial fluid in patients with rheumatoid arthritis; in Huskisson and Katona (Eds) Rheumatology, An Annual Review, Vol. 7, New Trends in Osteoarthritis, pp. 188–193 (Karger, Basel 1982).

    Google Scholar 

  • Daymond, T.J. and Herbert, R.: Fharmacokinetic studies of a high dose of tiaprofenic acid in patients suffering from arthritis. British Journal of Clinical Pharmacology 15: 157P-158P (1983).

    Google Scholar 

  • Daymond, T.J.; Thompson, M.; Akbar, F.A. and Chestney, V.: A controlled trial of tiaprofenic acid versus ibuprofen in rheumatoid arthritis. Rheumatology and Rehabilitation 18: 257–260 (1979).

    Article  PubMed  CAS  Google Scholar 

  • de Blécourt, J.J.; Oh, B.K. and Bernaert, A.C.A.M.M.: Tiaprofeenzur (Surgam®) een dubbelblind cross-over onderzoek. Tijdschrift voor Geneesmiddelenonderzoek 7: 1434–1437 (1982).

    Google Scholar 

  • de Carvalho, P.M.: A double-blind comparative trial of tiaprofenic acid and sulindac in osteoarthritis; in Berry and Franchimont (Eds) Tiaprofenic Acid. Papers presented at the 10th European Congress of Rheumatology, Moscow 26 June to 2 July, 1983, pp. 88–93 (Excerpta Medica, Geneva 1984).

    Google Scholar 

  • Démétriadès, P.: Tiaprofenic acid in the treatment of various rheumatic diseases; in Berry and Franchimont (Eds) Tiaprofenic Acid. Papers presented at the 10th European Congress of Rheumatology, Moscow 26 June to 2 July, 1983, pp. 97–103 (Excerpta Medica, Geneva 1984).

    Google Scholar 

  • Deraedt, R.: Jouquey. S.: Delevallée. F. and Flahaut. M.: Release of prostaglandins E and F in an algogenic reaction and its inhibition. European Journal of Pharmacology 61: 17–24 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Dcraedt. R.: Benzoni. J. and Delevallée. F.: Pharmacological profile of tiaprofenic acid: in Huskisson and Katona (Eds) Rheumatology: An Annual Review, Vol. 7, New Trends in Osteoarthritis, pp. 78–87 (Karger. Basel 1982).

    Google Scholar 

  • Diffey. B.L.; Daymond. T.J. and Fairgreaves, H.: Phototoxic reactions to piroxicam. naproxen and tiaprofenic acid. British Journal of Rheumatology 22: 239–242 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Doering. V.W. and lsbary, J/. per Einfluss von Tiaprofensäure auf die Digoxin-Konzentration im Serum. Arzneimittel-Forschung 33: 167–168 (1983).

    PubMed  CAS  Google Scholar 

  • Donald. J.F. and Molla, A.L.: A comparative double-blind study of tiaprofenic acid and aspirin in the treatment of muscular rheumatism, fibrositis. sprains and soft tissue injuries in general practice. Journal of International Medical Research 8: 382–387 (1980).

    PubMed  CAS  Google Scholar 

  • Dürr, J.: Pfeiffer M.H.: Penth. B.: Wetzelsberger, K. and Lücken P.W.: Untersuchung zur Frage einer Interaktion von Tiaprofensaure und Phenprocoumon. Arzneimittel-Forschung 31: 2163–2167 (1981).

    PubMed  Google Scholar 

  • Eastmond. C.J.: Hopkins, R. and Wright. V.: A comparative controlled study of tiaprofenic acid (’surgam’) and naproxen in the treatment of rheumatoid arthritis. Current Medical Research and Opinion 7: 605–609 (1982).

    Article  Google Scholar 

  • Feilet. A.J.: Toledo, A.H. and Scotton, A.S.: Double-blind comparison of a new anti-inflammatory nonsteroidal agent, tiaprofenic acid versus sulindac in osteoarthritis of the knees; in Huskisson and Katona (Eds) Rheumatology: An Annual Review. Vol. 7, New Trends in Osteoarthritis, pp. 173–181 (Karger. Basel 1982).

    Google Scholar 

  • Fernandes. L.; Beer, T.C.; Nichol, F.E.; Roy, S. and Yoxall, H.: Is the clinical efficacy of non-steroidal anti-inflammatory drugs related to their half-life? A study with tiaprofenic acid in rheumatoid arthritis; in Berry and Franchimont (Eds) Tiaprofenic Acid. Paper presented at the 10th European Congress o Rheumatology, Moscow. 26 June to 2 July, 1983, pp. 27–32 (Excerpta Medica, Geneva 1984).

    Google Scholar 

  • Franchimont, P.; Gysen, P.; Lecomte-Yern, M.J. and Malaise, M.: Non-steroidal anti-inflammatory agents and articular proteoglycans: in Berry and Franchimont (Eds) Tiaprofenic Acid. Paper presented at the 10th European Congress o Rheumatology, Moscow, 26 June to 2 July, 1983, pp. 3–14 (Excerpta Medica, Geneva 1984).

    Google Scholar 

  • Fujimura. H.; Tsurumi, K.; Hiramatsu, Y.; Tamura, Y.; Kokuba, S. and Yanagihara. M.: Pharmacological studies on 5-benzoyl-α-mcthyl-2-thiophene acetic acid (RU-15060). I. Anti-inflammatory and analgesic activities. Pharmacomctrics 9: 715–725 (1975).

    CAS  Google Scholar 

  • Galosi. A.; Przybilla, B.; Ring, J. and Dorn, M.: Photosensitizing potential of the nonsteroidal antiinflammatory drug (NSAID) tiaprofenic acid (TPA). (Abstract.) Journal of Allergy and Clinical Immunology 73 (Number 1, Part 2): 165 (1984).

    Google Scholar 

  • Hamza, M.; Surgam in the treatment of degenerative rheumatological conditions; in Bianchi and Colombo (Eds) New Trends in Osteoarthritis, Part II, pp. 23–26 (Karger, Basel 1983).

    Google Scholar 

  • Honig. W.J.: Pharmacokinetic study of tiaprofenic acid in synovial fluid; in Berry and Franchimont (Eds) Tiaprofenic Acid. Paper presented at the 10th European Congress o Rheumatology, Moscow, 26 June to 2 July, 1983, pp. 15–18 (Excerpta Medica, Geneva 1984).

    Google Scholar 

  • Kageyama, T.: Multi-center double-blind controlled study of tiaprofenic acid versus indomethacin in the treatment of osteoarthritis of the knee; in Huskisson and Katona (Eds) Rheumatology: An Annual Review, Vol. 7, New Trends in Osteoarthritis, pp. 164–172 (Karger, Basel 1982).

    Google Scholar 

  • Kaneto. H. and Matsui, Y.: Metabolic fate of tiaprofenic acid (RU-15060) (I) Absorption, distribution and excretion following oral administration in the rat and dog. Pharmacometrics 13: 399–409 (1977).

    CAS  Google Scholar 

  • Katona. G.: 4 years’ experience in rheumatology with tiaprofenic acid; in Bianchi and Colombo (Eds) New Trends in Osteoarthritis, Part II, pp. 27–39 (Karger, Basel 1983).

    Google Scholar 

  • Katona. G. and Burgos-Vargas, R.: A new derivative of propionic acid, tiaprofenic acid, and its efficacy in the treatment of rheumatoid arthritis: Comparative study with ibuprofen. Current Therapeutic Research 29: 1–11 (1981).

    Google Scholar 

  • Katona. G. and Burgos-Vargas, R.: Effect of tiaprofenic acid upon the gastric mucosa in patients with rheumatoid arthritis — assessed by gastroscopic studies. Presented at the Third International Seminar on the Treatment of Rheumatic Diseases, Israel. 13–20 November (1983).

  • Katona. G.: Burgos-Vargas, R. and Zimbrón, A.: Clinical trial of tiaprofenic acid in rheumatoid arthritis with scintigraphic study; in Huskisson and Katona (Eds) Rheumatology: An Annual Review, Vol. 7, New Trends in Osteoarthritis, pp. 136–142 (Karger, Basel 1982).

    Google Scholar 

  • Katona. G.: Burgos-Vargas. R. and Zimbrón, A.: Clinical trial of tiaprofenic acid in rheumatoid arthritis with scintigraphic studies; in Berry and Franchimont (Eds) Tiaprofenic Acid. Paper presented at the 10th European Congress of Rheumatology, Moscow, 26 June to 2 July, 1983, pp. 21–26 (Excerpta Medica, Geneva 1984).

    Google Scholar 

  • Kuhn, A.; Sauerland, S.; Schiffer, K. and Schrör, K.: The action of non-steroidal antiinflammatory agents on platelet aggregation and vessel tone in relation to inhibition of PGI2- and thromboxane-release, with particular reference to 5-benzoyl-α-methyl-2-thiophene acetic acid (tiaprofenic acid). Arzneimittel-Forschung 30; 1538–1542 (1980).

    PubMed  CAS  Google Scholar 

  • Lambert. J.R.; Cardoe, N.; Simpson, N.R.; Oldham, P.; Nichol, P.E. and Martin, L.: A controlled comparison of tiaprofenic acid and ibuprofen in osteoarthritis. (Abstract.) Presented at the International Conference on Inflammation: Antirheumatics. Analgesics and Immunomodulators, Venice, 16–18 April (1984).

  • Lange-Mechlen, I.; Davis, P.; Bass, A.; Hart, L.; Lafrenière, R.; Owen, R.; Grace, M. and Auclair, C.: Tiaprofenic acid (Surgam) and naproxen (Naprosyn) in osteoarthritis (OA) — results of a double blind study. Annals of the Royal College of Physicians and Surgeons of Canada 16: 391 (1983).

    Google Scholar 

  • Lücker, P.W.: Tiaprofenic acid: Gastric irritation compared to acetylsalicylic acid and indomethacin; in Bianchi and Colombo (Eds) New Trends in Osteoarthritis, Part II, pp. 1–8 (Karger, Basel 1983).

    Google Scholar 

  • Lücker, P.W.; Penth, B. and Wetzelsberger, K.: Pharmacokinetic interaction between tiaprofenic acid and several other compounds for chronic use; in Huskisson and Katona (Eds) Rheumatology: An Annual Review, Vol. 7, New Trends in Osteoarthritis, pp. 99–106 (Karger, Basel 1982).

    Google Scholar 

  • Maccagno, A. and Santoro, P.: Comparative study of tiaprofenic acid and diclofenac for the treatment of rheumatoid arthritis: in Huskisson and Katona (Eds) Rheumatology: An Annual Review, Vol. 7, New Trends in Osteoarthritis, pp. 143–150 (Karger, Basel 1982).

    Google Scholar 

  • Marcolongo, R.; Fioravanti, A.; Giordano, N.; Frati, E. and Maruani, A.M.: Tiaprofenic acid in the treatment of osteoarthritis of the knee; in Berry and Franchimont (Eds) Tiaprofenic Acid. Paper presented at the 10th European Congress of Rheumatology, Moscow, 26 June to 2 July, 1983, pp. 82–87 (Excerpta Medica, Geneva 1984).

    Google Scholar 

  • Marecek, N.; Lücker, P.W.; Penth, B.; Altmayer, P. and Wetzelsberger, K.: Zur Pharmakokinetik von Tiaprofensäure und zur Frage der Interaktion mit ASS und Aluminium-hydroxid. Arzneimittel-Forschung 31: 116–120 (1981).

    PubMed  CAS  Google Scholar 

  • McKenzie, L.S.; Horsburgh, B.A.; Ghosh, P. and Taylor, T.K.F.: Effect of antiinflammatory drugs on sulphated glycosaminoglycan synthesis in aged human articular cartilage. Annals of the Rheumatic Diseases 35: 487–497 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Meirovich, C.I.; Montrull, H.L.; Strusberg, A.M. and Brizuela, N.Y.: Antiinflammatory and synovial effects of tiaprofenic acid. Presented at the Second World Congress of Clinical Pharmacology, Washington (1983).

  • Meurice, J.: Interaction of tiaprofenic acid and acenocoumarol: in Huskisson and Katona (Eds) Rheumatology: An Annual Review, Vol. 7, New Trends in Osteoarthritis, pp. 111–117 (Karger, Basel 1982a).

    Google Scholar 

  • Meurice, J.; Evaluation of Surgam: long-term tolerance; in Huskisson and Katona (Eds) Rheumatology. An Annual Review: Vol. 7, New Trends in Osteoarthritis, pp. 182–187 (Karger, Basel 1982b).

    Google Scholar 

  • Meurice, J.: Treatment of osteoarthritis: a 3-month comparison between tiaprofenic acid and indomethacin. Current Medical Research and Opinion 8: 295–301 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Mirelli, E.: Effects of antirheumatic and anti-inflammatory drugs on the gastroduodenal mucosa; in Bianchi and Colombo (Eds) New Trends in Osteoarthritis, Part II, pp. 9–13 (Karger, Basel 1983).

    Google Scholar 

  • Moncada, S. and Vane, J.R.: Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin. Pharmacological Reviews 30: 293–331 (1979).

    Google Scholar 

  • Mungavin, J.M. and Clarke, T.K.: A multi-centre study of tiaprofenic acid (’surgam’) and five comparative drugs in rheumatoid arthritis and osteoarthritis in general practice. Current Medical Research and Opinion 8: 461–471 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Nahoul. K.; Dehennin, L. and Scholler, R.: Interference of tiaprofenic acid in Zimmermann reaction. Journal of Steroid Biochemistry 10: 471–473 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Neuhaus, V.; Ahland, B.; Rücker, W. and Schrör, K.: The actions of tiaprofenic acid on platelet aggregation and serum thromboxane levels in healthy volunteers ex vivo. Proceedings of the First International Austrian Prostaglandin Meeting, p. 23, Bad Ischl, 22–25 Sep (1982).

  • Nichol, F.; Ammitzboll, F.; Daymond, T.J.; Démétriadès, P.D.; Hingorani, K.; Loebl, W.Y.; Pesonen, J. and Wojtulewski, J.A.: Is the clinical efficacy of non-steroidal anti-inflammatory drugs related to their half-life? A study with tiaprofenic acid in osteoarthritis; in Berry and Franchimont (Eds) Tiaprofenic Acid. Paper presented at the 10th European Congress of Rheumatology, Moscow, 26 June to 2 July, 1983, pp. 65–69 (Excerpta Medica, Geneva 1984a).

    Google Scholar 

  • Nichol, F.E.; Daymond, T.J.; Pandit, N.A.; Sheldon, P. and Swannell, A.J.: A controlled trial of tiaprofenic acid versus indomethacin in the treatment of rheumatoid arthritis. Presented at the International Conference on Inflammation: Antirheumatics, Anaigesics and Immunomodulators, Venice, 16–18 April (1984b).

  • Nilsen, O.G.: The pharmacokinetics of tiaprofenic acid (Surgam®). Presented at the Eular Symposium on Arthrosis, Regensburg. 5–9 Sep (1984).

  • Ormiston, M.C.; Vaughton, K.C.; Thornton, E.J.; La Coste, JJ. and Milroy, E.: The comparative effectiveness of tiaprofenic acid and aspirin in the treatment of post-prostatectomy pain. British Journal of Clinical Practice 35: 360–362 (1981).

    PubMed  CAS  Google Scholar 

  • Palmoski, M.J. and Brandt, K.D.: Effects of some non steroidal antiinflammatory drugs on proteoglycan metabolism and organisation in canine articular cartilage. Arthritis and Rheumatism 23: 1010–1020 (1979).

    Article  Google Scholar 

  • Petera, P.; Tausch, G. and Eberl, R.: Doppelblindstudie mit Tiaprofensaure (Surgam®) gegen Ibuprofen (Brufen®) bei Patienten mit Arthrosen der knie- und Hüftgelenke. Weiner Medizinische Wochenschrift 133: 409–412 (1983).

    CAS  Google Scholar 

  • Peyron, J.G.: Double-blind comparative studies of tiaprofenic acid in degenerative joint diseases; in Huskisson and Katona (Eds) Rheumatology: An Annual Review, Vol. 7, New Trends in Osteoarthritis, pp. 151–158 (Karger, Basel 1982).

    Google Scholar 

  • Pottier, J.; Berlin, D. and Raynaud, J.P.: Pharmacokinetics of the anti-inflammatory tiaprofenic acid in humans, mice, rats, rabbits, and dogs. Journal of Pharmaceutical Sciences 66: 1030–1036 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Pottier, J.; Cousty-Berlin, D. and Busigny, M.: Human pharmacokinetics of tiaprofenic acid; in Huskisson and Katona (Eds) Rheumatology: An Annual Review, Vol. 7, New Trends in Osteoarthritis, pp. 70–77 (Karger, Basel 1982).

    Google Scholar 

  • Queiros, M.V.; Santo, J.E.; da Silva, J.P. and da Costa, J.T.: Tiaprofenic acid versus indomethacin in the treatment of rheumatoid arthritis; in Berry and Franchimont (Eds) Tiaprofenic Acid. Paper presented at the 10th European Congress of Rheumatology, Moscow, 26 June to 2 July, 1983, pp. 42–49 (Excerpta Medica, Geneva 1984).

    Google Scholar 

  • Rinaldi, E. and Telia, G.: A short-term double-blind trial of tiaprofenic acid and naproxen in osteoarthritis of the hip; in Huskisson and Katona (Eds) Rheumatology: An Annual Review, Vol. 7, New Trends in Osteoarthritis, pp. 159–163 (Karger, Basel 1982).

    Google Scholar 

  • Romanowicz. A.: Acido tiaprofenico en el tratamiento de la osteoartritis de cadera. Prensa Médica Argentina 69: 206–210 (1982).

    Google Scholar 

  • Romanowicz, A.: Tiaprofenic acid in the treatment of osteoarthritis of the knee. Presented at the Third International Seminar on the Treatment of Rheumatic Diseases, Israel, 13–20 Nov (1983).

  • Samprisi-Aprile, F.: Tiaprofenic acid: A brief review of its analgesic and anti-inflammatory action and a double-blind, controlled study in osteoarthritis of the knee compared with diclofenac sodium; in Bianchi and Colombo (Eds) New Trends in Osteoarthritis, Part II, pp. 14–19 (Karger, Basel 1983).

    Google Scholar 

  • Schrör, K.; Neuhaus, V.; Ahland, B.; Sauerland, S.; Kuhn, A.; Darius, H. and Bussman, K.: Actions of tiaprofenic acid on vascular prostacyclin biosynthesis and thromboxane and 12-HPETE formation of human platelets in vitro and ex vivo; in Huskisson and Katona (Eds) Rheumatology: An Annual Review, Vol. 7, New Trends in Osteoarthritis, pp. 88–98 (Karger, Basel 1982).

    Google Scholar 

  • Schrör, K.; Sauerland, S.; Kuhn, A. and Rosen, R.: Different sensitivities of prostaglandin-cyclooxygenases in blood platelets and coronary arteries against non-steroidal antiinflammatory drugs. Archives of Pharmacology 313: 69–76 (1980).

    Article  PubMed  Google Scholar 

  • Strusberg, A.M.; Arroyo, S.R.; Montrull, H.L.; Meirovich, C.I. and de Lamo, R.: Tiaprofenic acid pharmacokinetics in rheumatoid arthritis and osteoarthritis. Presented at the Third International Seminar on the Treatment of Rheumatic Diseases, Israel, 13–20 Nov (1983).

  • Sweet, M.B.; Thomas, E.; Immelman, A.R. and Solomon, L.: Biochemical changes in progressive osteoarthrosis. Annals of the Rheumatic Diseases 36: 387–398 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Thompson, M.; Daymond, T.J.; Essigman, W.K.; Huskisson, E.C. and Wojtulewski, J.A.: Short-term efficacy and tolerance of tiaprofenic acid (’surgam’) in rheumatoid arthritis and osteoarthritis: multi-centre, placebo-controlled trials. Current Medical Research and Opinion 8: 215–223 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Tognetti, G.P.: Trattamento delle osteoartrosi: confronto in doppio cieco tra Acido tiaprofenico e Piroxicam. Progresso Medico 39: 1–8 (1983).

    Google Scholar 

  • Trang, L.E.: Prostaglandins and inflammation. Seminars in Arthritis and Rheumatism 9: 153–190 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Triay, F.J.E.: Comparative clinical study of tiaprofenic acid vs naproxen in patients with osteoarthritis of the knee. Investigacion Médica Internacional 8: 218–228 (1981).

    Google Scholar 

  • Trop, D.; Nucci, C.; Elie, R. and Gareau, J.: Double-blind comparative evaluation of tiaprofenic acid (Surgam®) versus acetylsalicylic acid (ASA) in relieving pain following episiotomy. Current Therapeutic Research 34: 274–279 (1983).

    Google Scholar 

  • Vaz, A.L. and Martins, D.: A comparative controlled study of tiaprofenic acid and ibuprofen in the treatment of osteoarthritis of the knee; in Berry and Franchimont (Eds) Tiaprofenic Acid. Paper presented at the 10th European Congress of Rheumatology, Moscow, 26 June to 2 July, 1983, pp. 77–81 (Excerpta Medica, Geneva 1984).

    Google Scholar 

  • Viara, M.: Tiaprofenic acid in the treatment of rheumatoid arthritis; in Berry and Franchimont (Eds) Tiaprofenic Acid. Paper presented at the 10th European Congress of Rheumatology, Moscow, 26 June to 2 July, 1983, pp. 34–41 (Excerpta Medica, Geneva 1984).

    Google Scholar 

  • Ward, G.T.; Stead, J.A. and Freeman, M.: A rapid and specific method for the determination of tiaprofenic acid in human plasma by high-performance liquid chromatography. Journal of Liquid Chromatography 5: 165–174 (1982).

    Article  CAS  Google Scholar 

  • Warrington, S.J.; Halsey, A. and O’Donnell, L.: A comparison of gastrointestinal bleeding in healthy volunteers treated with tiaprofenic acid, aspirin or ibuprofen; in Huskisson and Katona (Eds) Rheumatology. An Annual Review, Vol. 7, New Trends in Osteoarthritis. pp. 107–110 (Karger, Basel 1982).

    Google Scholar 

  • Warrington, S.J.; Horton, M. and Davies, I.B.: High dose tiaprofenic acid, naproxen and aspirin: comparison of effects on gastrointestinal blood loss. (Abstract.) Presented at the Meeting of the British Pharmacological Society, April (1984).

  • Wojtulewski, J.A.; Daymond, T.J.; Démétriadès, P.D.; Essigman, W.K.; Khaled, A.; Pessonen, J. and Sturge, R.A.: Long-term efficacy and tolerance of tiaprofenic acid in rheumatoid arthritis and osteoarthritis; in Berry and Franchimont (Eds) Tiaprofenic Acid. Paper presented at the 10th European Congress of Rheumatology, Moscow, 26 June to 2 July, 1983, pp. 116–123 (Excerpta Medica, Geneva 1984).

    Google Scholar 

  • Wojtulewski, J.; Walter, J. and Thornton, E.J.: Tiaprofenic acid (Surgam) in the treatment of osteoarthritis of the knee and hip. Rheumatology and Rehabilitation 20: 177–180 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Zichner, L.: Experience with tiaprofenic acid (Surgam) in the treatment of osteoarthritis of the hip joint; in Huskisson and Katona (Eds) Rheumatology: An Annual Review, Vol. 7, New Trends in Osteoarthritis, pp. 194–198 (Karger, Basel 1982).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. ADIS Drug Information Services, P.O. Box 34-030, Birkenhead, Auckland 10, New Zealand

    Eugene M. Sorkin & R. N. Brogden

Authors
  1. Eugene M. Sorkin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. N. Brogden
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Various sections of the manuscript reviewed by: T.J. Daymond, Sunderland District General Hospital, Sunderland, England; P.D. Démétriadès, Rheumatology Department, Asklepieion Hospital, Voula Attikis, Greece; F.D. Hart, London, England; E.C. Huskisson, Department of Rheumatology, St Bartholomew’s Hospital, London, England; G. Katona, Rheumatology Service, Hospital General S.S.A., Mexico City, Mexico; J. Meurice, Hôpital Gériatrique et Maison de Repos, Liège, Belgium; S.H. Roth, Arthritis Center, St Luke’s Hospital, Phoenix, Arizona, USA; K. Sc>nrör, Pharmakologisches Institut der Universität Zu Köln, Cologne, Federal Republic of Germany; J.C. Steigerwald, Division of Rheumatic Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA; M. Thompson, University of Newcastle upon Tyne Teaching Hospital, Newcastle upon Tyne, England.

‘Surgam’, ‘Surgamic’, ‘Surgamyl’ (Roussel Laboratories).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sorkin, E.M., Brogden, R.N. Tiaprofenic Acid. Drugs 29, 208–235 (1985). https://doi.org/10.2165/00003495-198529030-00002

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00003495-198529030-00002

Keywords

Search

Navigation