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Drug Interactions with Oral Sulphonylurea Hypoglycaemic Drugs

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Summary

The effect of the oral sulphonylurea hypoglycaemic drugs may be influenced by a large number of other drugs. Some of these combinations (e.g. phenylbutazone, sulphaphenazole) may result in cases of severe hypoglycaemic collapse. Tolbutamide and chlorpropamide should never be given to a patient without a prior careful check of which medicaments are already being given. Similarly, no drug should be given to a diabetic treated with tolbutamide and chlorpropamide without consideration of the possibility of interaction phenomena.

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  1. Department of Internal Medicine and Endocrinology, Herlev Hospital, 2730, Herlev, Copenhagen, Denmark

    J. M. Hansen & L. K. Christensen

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  1. J. M. Hansen
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  2. L. K. Christensen
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Hansen, J.M., Christensen, L.K. Drug Interactions with Oral Sulphonylurea Hypoglycaemic Drugs. Drugs 13, 24–34 (1977). https://doi.org/10.2165/00003495-197713010-00003

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