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Prediction of Maintenance Dose Required to Attain a Desired Drug Concentration at Steady-state From a Single Determination of Concentration After an Initial Dose

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Summary

Strong correlations have been reported between drug concentrations at steady-state and a single drug concentration determined sometime after an initial dose for lithium, nortriptyline, Imipramine, desipramine, choramphenicol and theophylline. The mathematical basis of these relationships suggests that a one point method for predicting steady-state drug concentrations and individual dosing requirements should be widely applicable to most drugs and should be valid for patients having a wide range of drug half-lives.

A method is presented for evaluating the optimum time of blood sampling to determine a drug concentration in serum or plasma that best correlates with steady-state levels and for defining the range of drug half-lives beyond which the predictive approach is likely to give poor results.

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References

  • Braithwaite, R.; Montgomery, S. and Dawling, S.: Nortriptyline in depressed patients with high plasma levels. II. Clinical Pharmacology and Therapeutics 23: 303–308 (1978).

    PubMed  CAS  Google Scholar 

  • Brunswick, D.J.; Amsterdam, J.D.; Mendels, J. and Stern, S.L.: Prediction of steady-state Imipramine and desmethylimipra-mine plasma concentrations from single-dose data. Clinical Pharmacology and Therapeutics 25: 605–610 (1979).

    PubMed  CAS  Google Scholar 

  • Cooper, T.B.; Bergner, P.-E.E. and Simpson, G.M.: The 24-hour serum lithium level as a prognosticator of dosage requirements. American Journal of Psychiatry 130: 601–603 (1973).

    PubMed  CAS  Google Scholar 

  • Cooper, T.B. and Simpson, G.M.: The 24-hour lithium level as a prognosticator of dosage requirements: A 2-year follow-up study. American Journal of Psychiatry 133: 440–443 (1976).

    PubMed  CAS  Google Scholar 

  • Cooper, T.B. and Simpson, G.M.: Prediction of individual dosage of nortriptyline. American Journal of Psychiatry 135: 333–335 (1978).

    PubMed  CAS  Google Scholar 

  • Koup, J.R.; Sack, C.M.; Smith, A.L. and Gibaldi, M.: Hypothesis for the individualisation of drug dosage. Clinical Pharmacokinetics 5: 460–469 (1980).

    Google Scholar 

  • Montgomery, S.A.; McAuley, R.; Montgomery, D.B.; Braith-waite, R.A. and Dawling, S.: Dosage adjustment from simple nortriptyline spot level predictor tests in depressed patients. Clinical Pharmacokinetics 4: 129–136 (1979).

    Article  PubMed  CAS  Google Scholar 

  • Sheiner, L.B.; Beal, S.; Rosenberg, B. and Marathe, V.V.: Forecasting individual pharmacokinetics. Clinical Pharmacology and Therapeutics 26: 294–305 (1979).

    PubMed  CAS  Google Scholar 

  • Slattery, J.T.: A pharmacokinetic model-independent approach for estimating dose required to give desired steady-state through concentrations of drug in plasma. Journal of Pharmacokinetics and Biopharmaceutics 8: 105–110 (1980).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. School of Pharmacy, Department of Pharmaceutical Sciences and Pharmacy Practice, University of Washington, Seattle, USA

    John T. Slattery, Milo Gibaldi & Jeffery R. Koup

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  1. John T. Slattery
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  2. Milo Gibaldi
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  3. Jeffery R. Koup
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Slattery, J.T., Gibaldi, M. & Koup, J.R. Prediction of Maintenance Dose Required to Attain a Desired Drug Concentration at Steady-state From a Single Determination of Concentration After an Initial Dose. Clin Pharmacokinet 5, 377–385 (1980). https://doi.org/10.2165/00003088-198005040-00005

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  • DOI: https://doi.org/10.2165/00003088-198005040-00005

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