Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. (2006) Prevalence of overweight and obesity in the United States, 1999–2004. JAMA 295:1549–55.
Nathan C. (2002) Points of control in inflammation. Nature 420:846–52.
Hotamisligil GS, Shargill NS, Spiegelman BM. (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259:87–91.
Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 112:1796–808.
Xu H, et al. (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 112:1821–30.
Nishimura S, et al. (2008) In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue. J. Clin. Invest. 118:710–21.
Calle EE, Kaaks R. (2004) Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat. Rev. Cancer 4:579–91.
Christakis NA, Fowler JH. (2007) The spread of obesity in a large social network over 32 years. N. Engl. J. Med. 357:370–9.
Backhed F, Manchester JK, Semenkovich CF, Gordon JI. (2007) Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc. Natl. Acad. Sci. U. S. A. 104:979–84.
Desruisseaux MS, Nagajyothi, Trujillo ME, Tanowitz HB, Scherer PE. (2007) Adipocyte, adipose tissue, and infectious disease. Infect. Immun. 75:1066–78.
Cani PD, et al. (2007) Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56:1761–72.
Suganami T, Mieda T, Itoh M, Shimoda Y, Kamei Y, Ogawa Y. (2007) Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation. Biochem. Biophys. Res. Commun. 354:45–9.
Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444:1027–31.
Gerken T, et al. (2007) The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318:1469–72.
Frayling TM, et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316:889–94.
Yan SD, et al. (1994) Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. J. Biol. Chem. 269:9889–97.
Itoh Y, et al. (2003) Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature 422:173–6.
Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. (2006) TLR4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Invest. 116:3015–25.
Vikramadithyan RK, et al. (2005) Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice. J. Clin. Invest. 115: 2434–43.
Lesniewski LA, et al. (2007) Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. Nat. Med. 13:455–62.
Furuhashi M, et al. (2007) Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature 447:959–65.
Ehrt S, et al. (2001) Reprogramming of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase. J. Exp. Med. 194:1123–40.
Nathan C. (1992) Nitric oxide as a secretory product of mammalian cells. FASEB J. 6:3051–64.
Sundaresan M, Yu ZX, Ferrans VJ, Irani K, Finkel T. (1995) Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 270:296–9.
Stamler JS, Lamas S, Fang FC. (2001) Nitrosylation: the prototypic redox-based signaling mechanism. Cell 106:675–83.
Nathan C. (2003) Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling. J. Clin. Invest. 111:769–78.
Nathan C, Shiloh MU. (2000) Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proc. Natl. Acad. Sci. U. S. A. 97:8841–8.
Erusalimsky JD, Moncada S. (2007) Nitric oxide and mitochondrial signaling: from physiology to pathophysiology. Arterioscler. Thromb. Vasc. Biol. 27:2524–31.
O’Donnell-Tormey J, Nathan CF, Lanks K, DeBoer CJ, de la Harpe J. (1987) Secretion of pyruvate: an antioxidant defense of mammalian cells. J. Exp. Med. 165:500–14.
Richardson AR, Libby SJ, Fang FC. (2008) Anitric oxide-inducible lactate dehydrogenase enables Staphylococcus aureus to resist innate immunity. Science 319:1672–6.
Novak BJ, et al. (2007) Exhaled methyl nitrate as a noninvasive marker of hyperglycemia in type 1 diabetes. Proc. Natl. Acad. Sci. U. S. A. 104:15613–8.
Tsuchiya K, et al. (2007) Chronic blockade of nitric oxide synthesis reduces adiposity and improves insulin resistance in high fat-induced obese mice. Endocrinology 148:4548–56.
Brownlee M. (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813–20.
Lin Y, et al. (2005) The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. J. Biol. Chem. 280: 4617–26.
Houstis N, Rosen ED, Lander ES. (2006) Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440:944–948.
Nishikawa T, et al. (2000) Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404: 787–90.
Quijano C, Castro L, Peluffo G, Valez V, Radi R. (2007) Enhanced mitochondrial superoxide in hyperglycemic endothelial cells: direct measurements and formation of hydrogen peroxide and peroxynitrite. Am. J. Physiol. Heart Circ. Physiol. 293:H3404–14.
Ozcan U, et al. (2006) Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313: 1137–40.
Pospisilik JA, et al. (2007) Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell 131:476–91.
Furukawa S, et al. (2004) Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Invest. 114:1752–61.
Ramana KV, Fadl AA, Tammali R, Reddy AB, Chopra AK, Srivastava SK. (2006) Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages. J. Biol. Chem. 281:33019–29.
Janssens S, Tschopp J. (2006) Signals from within: the DNA-damage-induced NF-kappaB response. Cell Death Differ. 13:773–84.
Pacheco ME, Beltran A, Redondo J, Manso AM, Alonso MJ, Salaices M. (2006) High glucose enhances inducible nitric oxide synthase expression: role of protein kinase C-betaII. Eur. J. Pharmacol. 538:115–23.
Carreras MC, Poderoso JJ. (2007) Mitochondrial nitric oxide in the signaling of cell integrated responses. Am. J. Physiol. Cell Physiol. 292:C1569–80.
Du XL, Edelstein D, Dimmeler S, Ju Q, Sui C, Brownlee M. (2001) Hyperglycemia inhibits endothelial nitric oxide synthase activity by post-translational modification at the Akt site. J. Clin. Invest. 108:1341–8.
Kwon NS, Nathan CF, Stuehr DJ. (1989) Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages. J. Biol. Chem. 264:20496–501.
Xu J, Wu Y, Song P, Zhang M, Wang S, Zou MH. (2007) Proteasome-dependent degradation of guanosine 5′-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus. Circulation 116:944–53.
Upmacis RK, et al. (2007) Profound biopterin oxidation and protein tyrosine nitration in tissues of ApoE-null mice on an atherogenic diet: contribution of inducible nitric oxide synthase. Am. J. Physiol. Heart Circ. Physiol. 293:H2878–87.
Yin L, et al. (2007) Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways. Science 318:1786–9.
Odegaard JI, et al. (2007) Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature 447:1116–20.
Schopfer FJ, et al. (2005) Nitrolinoleic acid: an endogenous peroxisome proliferator-activated receptor gamma ligand. Proc. Natl. Acad. Sci. U. S. A. 102:2340–5.
Pascual G, et al. (2005) A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature 437:759–63.
Hosogai N, et al. (2007) Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 56:901–11.
Ye J, Gao Z, Yin J, He Q. (2007) Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am. J. Physiol. Endocrinol. Metab. 293:E1118–28.
Guzy RD, et al. (2005) Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab. 1:401–8.
Chen R, Yang L, McIntyre TM. (2007) Cytotoxic phospholipid oxidation products. Cell death from mitochondrial damage and the intrinsic caspase cascade. J. Biol. Chem. 282:24842–50.
Cinti S, et al. (2005) Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J. Lipid Res. 46:2347–55.
Kanda H, et al. (2006) MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J. Clin. Invest. 116:1494–505.
Alisjahbana B, et al. (2007) The effect of type 2 diabetes mellitus on the presentation and treatment response of pulmonary tuberculosis. Clin. Infect. Dis. 45:428–35.
Restrepo BI. (2007) Convergence of the tuberculosis and diabetes epidemics: renewal of old acquaintances. Clin. Infect. Dis. 45:436–8.
Stevenson CR, et al. (2007) Diabetes and tuberculosis: the impact of the diabetes epidemic on tuberculosis incidence. BMC Public Health 7:234.
Stalenhoef JE, et al. (2007) The role of interferon-gamma in the increased tuberculosis risk in type 2 diabetes mellitus. Eur. J. Clin. Microbiol. Infect. Dis. 27:97–103.
Nathan CF, Murray HW, Wiebe ME, Rubin BY. (1983) Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J. Exp. Med. 158:670–89.
Fortin A, Abel L, Casanova JL, Gros P. (2007) Host genetics of mycobacterial diseases in mice and men: forward genetic studies of BCG-osis and tuberculosis. Annu. Rev. Genomics Hum. Genet. 8:163–92.
Kensler TW, Wakabayashi N, Biswal S. (2007) Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu. Rev. Pharmacol. Toxicol. 47:89–116.
Yates MS, et al. (2007) Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. Mol. Cancer Ther. 6:154–62.
House of Lords, Select Committee on Science and Technology. c1998. Science and Technology-Seventh Report [Internet]. House of Lords; [cited 2008 Feb 23]. Available from: https://doi.org/www.parliament.the-stationery-office.co.uk/pa/ld199798/ldselect/ldsctech/081vii/st0701.htm.
Consumer concerns about hormones in food: fact sheet #37 [Internet]. c2008. Ithaca, NY: Program on Breast Cancer and Environmental Risk Factors, Cornell University, College of Veterinary; [updated 2003 May 2; cited 2008 Feb 23]. Available from: https://doi.org/envirocancer.cornell.edu/Factsheet/Diet/fs37.hormones.cfm.
Donn J, Mendoza M, Pritchard J. March 9, 2008. AP: drugs show up in Americans’ water. USA Today [Internet]. [updated 2008 Mar 11; cited 2008 Feb 23]. Available from: https://doi.org/www.usatoday.com/news/health/2008-03-09-water_N.htm.