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Optimal Peak Separation Derived from Information Theory of Chromatography

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Abstract

The optimal separation of peaks in column chromatography is derived from information theory based on FUM1. The optimal is shown to be described by the chromatographic resolution Rs. The information theory of column chromatography demonstrates that optimization based on FUMI can entail optimization on Rs as a special case. The peak capacity can also be derived theoretically from FUMI.

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Hayashi, Y. Optimal Peak Separation Derived from Information Theory of Chromatography. ANAL. SCI. 6, 257–260 (1990). https://doi.org/10.2116/analsci.6.257

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  • DOI: https://doi.org/10.2116/analsci.6.257

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