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Square Wave and Square Wave Adsorptive Stripping Voltammetric Comparison of the Anti-Inflammatory Drugs Piroxicam and Tenoxicam

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Abstract

Two nonsteroid anti-inflammatory drugs, Piroxicam and Tenoxicam, are shown to be strongly adsorbed on mercury electrodes. Using this phenomenon to accumulate these compounds at the static mercury-drop electrode prior to square-wave voltammetric measurement, sub-nanomole sensitivities are readily achieved. A preconcentration potential of —0.6 V vs. Ag/AgCl/ KCl(s) was used for both drugs. The adsorptive stripping response was evaluated with respect to accumulation time and potential, analyte concentration, and electrolyte nature and concentration. Ascorbic acid up to 1X10-4 M has no effect on the Piroxicam peak, but results in enhanced response for the Tenoxicam adsorptive stripping peak. Studies were performed at p. 4.0 and 2.0 for the two drugs; at these values two and four electrons are transferred, respectively. The detection limit was 7X1010 M for Piroxicam and 1X10-10 M for Tenoxicam, the latter being even more sensitive (5×10-11 M) in the presence of ascorbic acid. Applicability of square wave voltammetry to urine samples was demonstrated. The detection limit is 5×10-8 M and 5×10-9 M (in presence of 1×10-5 M ascorbic acid) for Piroxicam and Tenoxicam, respectively, in urine samples diluted ten-fold with the supporting electrolyte.

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Author notes

  1. N. Abo El-Maali

    Present address: On leave from Department of Chemistry, Faculty of Science, Assiut University, Assiut, Egypt

Authors and Affiliations

  1. Institute of Pharmacy, CP205/6, Free University of Bruxelles, Boulevard of Triumph, 1050, Bruxelles, Belgium

    N. Abo El-Maali, J.-C. Vihe & G. J. Patriarche

  2. Department of Chemistry, Faculty of Science, Assiut University, Assiut, Egypt

    M. A. Ghandour

  3. Department of Chemistry, BG-10, University of Washington, Seattle, WA, 98195, USA

    G. D. Christian

Authors
  1. N. Abo El-Maali
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  2. J.-C. Vihe
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  3. G. J. Patriarche
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  4. M. A. Ghandour
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  5. G. D. Christian
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El-Maali, N.A., Vihe, JC., Patriarche, G.J. et al. Square Wave and Square Wave Adsorptive Stripping Voltammetric Comparison of the Anti-Inflammatory Drugs Piroxicam and Tenoxicam. ANAL. SCI. 6, 245–250 (1990). https://doi.org/10.2116/analsci.6.245

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  • DOI: https://doi.org/10.2116/analsci.6.245

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