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Voltammetric behavior and quantitative determination of ambazone concentrations in urine and in a pharmaceutical formulation

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Central European Journal of Chemistry

Abstract

The use of square wave adsorptive stripping voltammetry (SWAdSV) in conjunction with a cyclic renewable silver amalgam film electrode (Hg(Ag)FE) for the analytical determination of ambazone in urine samples and pharmaceutical formulations is described. A single reduction peak in Britton-Robinson buffer at pH 4.0 was detected at about −1.4 V versus Ag/AgCl. Mechanistic studies have shown that the compound can act as an electrocatalyst. The method was validated. The analytical curve was linear in the concentration range from 1.0×10−9 to 1.0×10−7 mol L−1. The detection and quantification limits were found to be 3.0×10−10 mol L−1 and 1.0×10−9 mol L−1, respectively. The proposed method was successfully applied to ambazone determination in real samples.

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Authors and Affiliations

  1. Department of Inorganic and Analytical Chemistry, Faculty of Chemistry, University of Lodz, 91-403, Lodz, Poland

    Sylwia Smarzewska, Dariusz Guziejewski, Monika Skowron, Slawomira Skrzypek & Witold Ciesielski

Authors
  1. Sylwia Smarzewska
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  2. Dariusz Guziejewski
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  3. Monika Skowron
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  4. Slawomira Skrzypek
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  5. Witold Ciesielski
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Correspondence to Sylwia Smarzewska.

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Smarzewska, S., Guziejewski, D., Skowron, M. et al. Voltammetric behavior and quantitative determination of ambazone concentrations in urine and in a pharmaceutical formulation. cent.eur.j.chem. 12, 1239–1245 (2014). https://doi.org/10.2478/s11532-014-0574-7

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  • DOI: https://doi.org/10.2478/s11532-014-0574-7

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