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A Fluorescence Probe Based on Biomolecule-stabilized Gold Nanoclusters for the Detection of Pazufloxacin Mesilate

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Abstract

In the present study, biomolecule-stabilized Au nanoclusters were demonstrated as a novel fluorescence probe for sensitive and selective detection of pazufloxacin mesilate (PZFX) for the first time. The linear decrease in the fluorescence intensity of Au nanoclusters induced by PZFX allowed for the quantitative detection of PZFX in the range of 0.15 μg/mL to 1 mg/mL, and the detection limit for PZFX was 0.2 μg/mL. Circular dichroism spectroscopy and fluorescence decay studies were then performed to discuss the quenching mechanism. In addition, practical application of the present approach was also demonstrated for real samples, which suggested its great potential for accurate analysis of similar drugs.

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Authors and Affiliations

  1. State Key Laboratory of Supramolecular Structure and Materials, Jilin University, No. 2699, Qianjin Street, 130012, Changchun, P. R. China

    Xueling Cao, Lili Lian, Hongwei Li & Yuqing Wu

  2. Department of Chemistry, Jilin Institute of Chemical Technology, No. 45 Chengde Street, 132022, Jilin, P. R. China

    Xueling Cao, Lili Lian & Dawei Lou

Authors
  1. Xueling Cao
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  2. Lili Lian
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  3. Hongwei Li
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  4. Yuqing Wu
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  5. Dawei Lou
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Correspondence to Dawei Lou.

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Cao, X., Lian, L., Li, H. et al. A Fluorescence Probe Based on Biomolecule-stabilized Gold Nanoclusters for the Detection of Pazufloxacin Mesilate. ANAL. SCI. 30, 817–822 (2014). https://doi.org/10.2116/analsci.30.817

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  • DOI: https://doi.org/10.2116/analsci.30.817

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