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Application of gold nanoclusters in fluorescence sensing and biological detection

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Abstract

Gold nanoclusters (Au NCs) exhibit broad fluorescent spectra from visible to near-infrared regions and good enzyme-mimicking catalytic activities. Combined with excellent stability and exceptional biocompatibility, the Au NCs have been widely exploited in biomedicine such as biocatalysis and bioimaging. Especially, the long fluorescence lifetime and large Stokes shift attribute Au NCs to good probes for fluorescence sensing and biological detection. In this review, we systematically summarized the molecular structure and fluorescence properties of Au NCs and highlighted the advances in fluorescence sensing and biological detection. The Au NCs display high sensitivity and specificity in detecting iodine ions, metal ions, and reactive oxygen species, as well as certain diseases based on the fluorescence activities of Au NCs. We also proposed several points to improve the practicability and accelerate the clinical translation of the Au NCs.

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Funding

This work was financially supported by the National Key Research and Development Program of China (2021YFF1200700), the National Natural Science Foundation of China (Grant Nos. 91859101, 81971744, U1932107, 82001952, 11804248, 82302361, and 82302381), the Outstanding Youth Funds of Tianjin (2021FJ-0009), the National Natural Science Foundation of Tianjin (Nos. 19JCZDJC34000, 20JCYBJC00940, 21JCYBJC00550, 21JCZDJC00620, and 21JCYBJC00490), the Innovation Foundation of Tianjin University, and CAS Interdisciplinary Innovation Team (JCTD-2020-08).

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  1. Kexin Tan and Huizhen Ma have contributed equally to this work.

Authors and Affiliations

  1. Tianjin Key Laboratory of Brain Science and Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, 300072, China

    Kexin Tan, Huizhen Ma, Xiaoyu Mu, Hao Wang & Xiao-Dong Zhang

  2. Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin University, Tianjin, 300350, China

    Huizhen Ma & Xiao-Dong Zhang

  3. Department of Radiobiology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing, China

    Zhidong Wang & Qi Wang

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  1. Kexin Tan
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Contributions

Conceptualization, Xiao Dong Zhang and Kexin Tan; investigation, Kexin Tan and Xiaoyu Mu; writing, original draft, Kexin Tan and Huizhen Ma; writing, review and editing, Kexin Tan and Huizhen Ma; formal analysis, Zhidong Wang; validation, Qi Wang and Hao Wang; supervision, Xiao Dong Zhang and Hao Wang.

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Tan, K., Ma, H., Mu, X. et al. Application of gold nanoclusters in fluorescence sensing and biological detection. Anal Bioanal Chem (2024). https://doi.org/10.1007/s00216-024-05220-0

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