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Pore-forming Compounds as Signal Transduction Elements for Highly Sensitive Biosensing

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Abstract

Pore-forming compounds are attracting much attention due to the signal transduction ability for the development of highly sensitive biosensing. In this review, we describe an overview of the recent advances made by our group in the design of molecular sensing interfaces of spherical and planar lipid bilayers and natural bilayers. The potential uses of pore- forming compounds, such as gramicidin and MCM-41, in lipid bilayers and natural glutamate receptor channels in biomembrane are presented.

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7 References

  1. Q. Liu and B. J. Boyd, Analyst, 2013, 138, 391.

    Article  CAS  PubMed  Google Scholar 

  2. P. Kongsuphol, K. B. Fang, and Z. Diang, Sens. Actuators, B, 2013, 185, 530.

    Article  CAS  Google Scholar 

  3. A Hirano, A. Oshima, H. Mozumi, Y. Kimura, and M. Niwano, Anal. Sci ., 2012, 28, 1049.

    Article  Google Scholar 

  4. L. Steller, M. Kreier, and R. Salzer, Anal. Bioanal. Chem., 2012, 402, 209.

    Article  CAS  PubMed  Google Scholar 

  5. E. C. Yusko, J. M. Johnson, S. Majd, P. Prangkio, R. C. Rollings, J. Li, J. Yang, and M. Mayer, Nat. Nanotechnol., 2011, 6, 253.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. A. Liu, Q. Zhao, and X. Guan, Anal. Chim. Acta, 2010, 675, 106.

    Article  CAS  PubMed  Google Scholar 

  7. S. Majd, E. C. Yusko, Y. N. Billeh, M. X. Macrae, J. Yang, and M. Mayer, Curr. Opin. Biotechnol., 2010, 21, 439.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. L.-Q. Gu and J. W. Shim, Analyst, 2010, 135, 441.

  9. M. Balley, K. Bailey, K. Sugihara, D. Grieshaber, J. Vörös, and B. Städler, Small, 2010, 6, 2481.

    Article  CAS  Google Scholar 

  10. L. Movileanu, Trends Biotechnol., 2009, 27, 333.

    Article  CAS  PubMed  Google Scholar 

  11. A. Hirano-Iwata, M. Niwano, and M. Sugawara, TrAC, Trends Anal. Chem., 2008, 27, 512.

    Article  CAS  Google Scholar 

  12. E. T. Castellana and P. S. Cremer, Surf. Sci. Rep., 2006, 61, 429.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. M. Sugawara, A. Hirano, P. Bühlmann, and Y. Umezawa, Bull. Chem. Soc. Jpn., 2002, 75, 187.

    Article  CAS  Google Scholar 

  14. D. W. Urry, Proc. Natl. Acad. Sci. U. S. A., 1971, 68, 672.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. E. Bamberg and P. Läuger, J. Membr. Biol., 1973, 11, 177.

    Article  CAS  PubMed  Google Scholar 

  16. J. R. Elliott, D. Needham, J. P. Dilger, and D. A. Haydon, Biochim. Biophys. Acta, 1983, 735, 95.

    Article  CAS  PubMed  Google Scholar 

  17. J. A. Lundbæk, S. A. Collingwood, H. I. Ingo’lfsson, R. Kapoor, and O. S. Andersen, J. R. Soc. Interface, 2010, 7, 373.

    Article  PubMed  CAS  Google Scholar 

  18. B. A. Lewis and D. M. Engelman, J. Mol. Biol., 1983, 166, 211.

    Article  CAS  PubMed  Google Scholar 

  19. V. S. Rudnev, L. N. Ermishkin, L. A. Fonina, and Yu. G. Rovin, Biochim. Biophys. Acta, 1981, 642, 196.

    Article  CAS  PubMed  Google Scholar 

  20. H.-A. Kolb and E. Bamberg, Biochim. Biophys. Acta, 1977, 464, 127.

    Article  CAS  PubMed  Google Scholar 

  21. J. A. Lundbæk, P. Birn, J. Girshman, A. J. Hansen, and O. S. Andersen, Biochemistry, 1996, 35, 3825.

    Article  PubMed  Google Scholar 

  22. N. Mobashery, C. Nielsen, and O. S. Andersen, FEBS Lett., 1997, 412, 15.

    Article  CAS  PubMed  Google Scholar 

  23. T. A. Harroun, W. T. Heller, T. M. Weiss, L. Yang, and H. W. Huang, Biophys. J., 1999, 76, 937.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. W. Rawicz, K. C. Olbrich, T. Mclntosh, D. Needham, and E. Evans, Biophys. J., 2000, 79, 328.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. B. Martinac and O. P. Hamill, Proc. Natl. Acad. Sci. U. S. A., 2002, 99, 4308.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. H.-J. Apell, E. Bamberg, and P. Läuger, Biochim. Biophys. Acta, 1979, 552, 369.

    Article  CAS  PubMed  Google Scholar 

  27. T. K. Rostovtseva, V. M. Aguilella, I. Vodyanoy, S. M. Berzrukov, and V. A. Parsegian, Biophys. J., 1998, 75, 1783.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. E. Neher and H. Eibl, Biochim. Biophys. Acta, 1977, 464, 37.

    Article  CAS  PubMed  Google Scholar 

  29. J. Girshman, D. V. Greathouse, R. E. Koepper, and O. S. Andersen, Biophys. J., 1997, 73, 1310.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. M. Weinrich, T. K. Rostovtseva, and S. M. Bezrukov, Biochemstry, 2009, 48, 5501.

    Article  CAS  Google Scholar 

  31. H. Okada, K. Hosokawa, and M. Maeda, Anal Sci., 2011, 27, 237.

    Article  CAS  PubMed  Google Scholar 

  32. J. Wang, X. Wang, Y. Li, S. Yan, Q. Zhou, B. Gao, J. Peng, J. Du, Q. Fu, S. Jia, J. Zhang, and L. Zhan, Anal. Sci., 2012, 28, 237.

    Article  CAS  PubMed  Google Scholar 

  33. I. Diala, S. Sato, M. Usui, K, Nakashima, T. Nishihara, and S. Takenaka, Anal. Sci., 2013, 29, 927.

    Article  CAS  PubMed  Google Scholar 

  34. Y. Dotsikas and Y. L. Loukas, Anal. Sci., 2012, 28, 753.

    Article  CAS  PubMed  Google Scholar 

  35. M. Horie, H. Yanagisawa, and M. Sugawara, Anal. Biochem., 2007, 369, 192.

    Article  CAS  PubMed  Google Scholar 

  36. A. Shoji, E. Sugimoto, S. Orita, K. Nozawa, A. Yanagida, Y. Shibusawa, and M. Sugawara, Anal. Bioanal. Chem., 2010, 397, 1377.

    Article  CAS  PubMed  Google Scholar 

  37. M. Otsuka and K. Yoshioka, Physiol. Rev., 1993, 73, 229.

    Article  CAS  PubMed  Google Scholar 

  38. H. Satake and T. Kawada, Curr. Drug Targets, 2006, 7, 963.

    Article  CAS  PubMed  Google Scholar 

  39. N. E. Garrett, P. I. Mapp, S. C. Cruwys, B. L. Kidd, and D. R. Blake, Ann. Rheum. Dis., 1992, 51, 1014.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. J. E. Keeble and S. D. Brain, Neurosci. Lett., 2004, 361, 176.

    Article  CAS  PubMed  Google Scholar 

  41. P. Holzer, Digestion, 1998, 59, 269.

    Article  CAS  PubMed  Google Scholar 

  42. C. Bouras, P. G. Vallet, P. R. Hof, Y. Charnay, J. Golaz, and J. Constantinidis, Alzheimer Dis. Assoc. Disord., 1990, 4, 24.

    Article  CAS  PubMed  Google Scholar 

  43. P. J. Gresch and P. D. Walker, Neuroscience, 1999, 93, 831.

    Article  CAS  PubMed  Google Scholar 

  44. S. H. Buck, T. F. Burks, M. R. Brown, and H. I. Yamamura, Brain Res., 1981, 209, 464.

    Article  CAS  PubMed  Google Scholar 

  45. E. W. Todd, J. Exp. Med., 1932, 55, 267.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. J. B. Zabriskie, J. Exp. Med., 1971, 134, 180.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. E. Ben-Chetrit, A. E. Moses, N. Agmon-Levin, C. Block, and E. Ben-Chetrit, Int. J. Rheum. Dis., 2012, 15, 78.

    Article  CAS  PubMed  Google Scholar 

  48. M. A. Gerber, L. S. Caparas, and M. F. Randolph, J. Clin. Microbiol., 1990, 28, 413.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. K. Kubotsu, I. Ushio, K. Yoshikawa, M. Kida, K. Ishikawa, S. Matsuura, and I. Sakurabayashi, Clin. Chem., 1990, 36, 1747.

    Article  CAS  PubMed  Google Scholar 

  50. M. Umeda, T. Tomita, H. Shibata, M. Seki, and T. Yasuda, J. Clin. Microbiol., 1988, 26, 804.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. L. A. Heath-Francica and E. G. Estévez, Diagn. Microbiol. Infect. Dis., 1987, 8, 25.

    Article  Google Scholar 

  52. T. Kodama, S. Ichiyama, Y. Morishita, T. Fukatsu, K. Shimokata, and N. Nakashima, J. Clin. Microbiol., 1997, 35, 839.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. M. Sakamoto, A. Shoji, and M. Sugawara, Anal. Sci., 2013, 29, 877.

    Article  CAS  PubMed  Google Scholar 

  54. Y. Suzuki, H. Itoh, T. Abe, F. Nishimura, Y. Sato, and M. Takeyama, Biol. Pharm. Bull., 2011, 34, 1640.

    Article  CAS  PubMed  Google Scholar 

  55. A. Nemmar, P. Gustin, A. Delaunois, J.-F. Beckers, and J. Sulon, Pharmacol. Toxicol. Methods, 1998, 39, 109.

    Article  CAS  Google Scholar 

  56. A. Lambiase, S. Bonini, A. Micera, P. Tirassa, L. Magrini, S. Bonini, and L. Aloe, Invest. Ophthalmol. Visual Sci., 1997, 38, 2161.

    CAS  Google Scholar 

  57. P. Pradelles, J. Grassi, C. Créminon, B. Boutten, and S. Mamas, Anal. Chem., 1994, 66, 16.

    Article  CAS  PubMed  Google Scholar 

  58. J. Horak, B. Enderle, H. Bakirci, and G. A. Urban, Sensors, IEEE, 2009, 1878.

  59. B. A. Cornell, V. L. B. Braach-Maksvytis, L. G. King, P. D. J. Osman, B. Raguse, L. Wieczorek, and R. J. Pace, Nature, 1997, 387, 580.

    Article  CAS  PubMed  Google Scholar 

  60. S. W. Lucas and M. M. Harding, Anal. Biochem., 2000, 282, 70.

    Article  CAS  Google Scholar 

  61. S. Futaki, Y. Zhang, T. Kiwada, I. Nakase, T. Yagami, S. Oiki, and Y. Sugiura, Bioorg. Med. Chem., 2004, 12, 1343.

    Article  CAS  PubMed  Google Scholar 

  62. M. X. Macrae, S. Blake, X. Jiang, R. Capone, D. J. Estes, M. Mayer, and J. Yang, ACS Nano, 2009, 3, 3567.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. A. Hirano, M. Wakabayashi, Y. Matsuno, and M. Sugawara, Biosens. Bioelectron., 2003, 18, 973.

    Article  CAS  PubMed  Google Scholar 

  64. Y. Matsuno, C. Osono, A. Hirano, and M. Sugawara, Anal. Sci., 2004, 20, 1217.

    Article  CAS  PubMed  Google Scholar 

  65. M. Nishio, A. Shoji, and M. Sugawara, Anal. Sci., 2012, 28, 661.

    Article  CAS  PubMed  Google Scholar 

  66. J. Kasianowicz, E. Brandin, D. Branton, and D. W. Deamer, Proc. Natl. Acad. Sci. U. S. A., 1996, 93, 13770.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. M. Akeson, D. Branton, J. J. Kasianowicz, E. Brandin, and D. W. Deamer, Biophys. J., 1999, 77, 3227.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. A. Meller, L. Nivon, E. Brandin, J. Golovchenko, and D. Branton, Proc. Natl. Acad. Sci. U. S. A., 2000, 97, 1079.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. J. W. Shim and L. Q. Gu, Anal. Chem., 2007, 79, 2207.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. O. Braha, L.-Q. Gu, L. Zhou, X. Lu, S. Cheley, and H. Bayley, Nat. Biotechnol., 2000, 18, 1005.

    Article  CAS  PubMed  Google Scholar 

  71. S. Majd, E. C. Yusko, Y. N. Billeh, M. X. Macrae, J. Yang, and M. Mayer, Curr. Opin. Biotechnol., 2010, 21, 439.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. L.-Q. Gu, O. Braha, S. Conlan, S. Cheley, and H. Bayley, Nature, 1999, 398, 686.

    Article  CAS  PubMed  Google Scholar 

  73. H.-C. Wu, Y. Astier, G. Maglia, E. Mikhailova, and H. Bayley, J. Am. Chem. Soc., 2007, 129, 16142.

    Article  CAS  PubMed  Google Scholar 

  74. C. T. Kresge, M. E. Leonowicz, W. J. Roth, J. C. Vartuli, and J. S. Beck, Nature, 1992, 359, 710.

    Article  CAS  Google Scholar 

  75. T. Yanagisawa, T. Shimizu, K. Kuroda, and C. Kato, Bull. Chem. Soc. Jpn., 1990, 63, 988.

    Article  CAS  Google Scholar 

  76. J. S. Beck, J. C. Vartuli, W. J. Roth, M. E. Leonowicz, C. T. Kresge, K. D. Schmitt, C.T.-W. Chu, D. H. Olson, E. W. Sheppard, S. B. McCullen, J. B. Higgins, and J. L. Schlenker, J. Am. Chem. Soc., 1992, 114, 10834.

    Article  CAS  Google Scholar 

  77. S. Inagaki, Y. Fukushima, and K. Kuroda, J. Chem. Soc., Chem. Commun., 1993, 8, 680.

    Article  Google Scholar 

  78. N. K. Mal, M. Fujiwara, and Y. Tanaka, Nature, 2003, 421, 350.

    Article  CAS  PubMed  Google Scholar 

  79. N. K. Mal, M. Fujiwara, Y. Tanaka, T. Taguchi, and M. Matsukata, Chem. Mater., 2003, 15, 3385.

    Article  CAS  Google Scholar 

  80. M. Fujiwara, K. Shiokawa, N. Kawasaki, and Y. Tanaka, Adv. Funct. Mater., 2003, 13, 371.

    Article  CAS  Google Scholar 

  81. M. Ahola, P. Kortesuo, I. Kangasniemi, J. Kiesvaara, and A. Yli-Urpo, Int. J. Pharm., 2000, 195, 219.

    Article  CAS  PubMed  Google Scholar 

  82. D. Arcos, C. V. Ragel, and M. Vallet-Regí, Biomaterials, 2001, 22, 701.

    Article  CAS  PubMed  Google Scholar 

  83. T. Czuryszkiewicz, J. Ahvenlammi, P. Kortesuo, M. Ahola, F. Kleitz, M. Jokinen, M. Lindén, and J. B. Rosenholm, J. Non-Cryst. Solids, 2002, 306, 1.

    Article  CAS  Google Scholar 

  84. M. Vallet-Regi, A. Rámila, R. P. del Real, and J. Pérez- Pariente, Chem. Mater., 2001, 13, 308.

    Article  CAS  Google Scholar 

  85. M. Alvaro, B. Ferrer, H. García, and F. Rey, Chem. Commun., 2002, 2012.

  86. K. Hoffmann, U. Resch-Genger, and F. Marlow, Microporous Mesoporous Mater., 2000, 41, 99.

    Article  CAS  Google Scholar 

  87. G. Wirnsberger, B. J. Scott, B. F. Chmelka, and G. D. Stucky, Adv. Mater., 2000, 12, 1450.

    Article  CAS  Google Scholar 

  88. C. Schomburg, M. Wark, Y. Rohlfing, G. Schulz-Ekloff, and D. Wöhrle, J. Mater. Chem., 2001, 11, 2014.

    Article  CAS  Google Scholar 

  89. K. Nozawa, C. Osono, and M. Sugawara, Sens. Actuators, B, 2007, 126, 632.

    Article  CAS  Google Scholar 

  90. M. Sugawara and A. Hirano, H. T. Tien and A. Ottova (eds.), “Advances in Planar Lipid Bilayers and Liposomes: Recent Progress—2003/4”, 2005, Chap. 8, Elsevier, Amsterdam, 221.

  91. A. Hirano, M. Wakabayashi, M. Sugawara, S. Uchino, and S. Nakajima-Iijima, Anal. Biochem., 2000, 283, 258.

    Article  CAS  PubMed  Google Scholar 

  92. H. Hauser, I. Pascher, R. H. Pearson, and S. Sundell, Biochim. Biophys. Acta, 1981, 650, 21.

    Article  CAS  PubMed  Google Scholar 

  93. K. Nozawa, A. Oshima, T. Nasu, A. Shoji, A. Hirano-Iwata, M. Niwano, and M. Sugawara, Sens. Actuators, B, 2011, 160, 139.

    Article  CAS  Google Scholar 

  94. M. E. Soderquist and A. G. Walton, J. Colloid Interface Sci., 1980, 75, 386.

    Article  CAS  Google Scholar 

  95. M. L. Hair and W. Hertl, J. Phys. Chem., 1970, 74, 91.

    Article  CAS  Google Scholar 

  96. R. A. Van Wagenen, J. D. Andrade, and J. B. Hibbs, J. Electrochem. Soc., 1976, 123, 1438.

    Article  Google Scholar 

  97. G. Schulz-Ekloff, D. Wöhrle, B. V. Duffel, and R. A. Schoonheydt, Microporous Mesoporous Mater., 2002, 51, 91.

    Article  CAS  Google Scholar 

  98. J. Tu, N. Li, Y. Chi, S. Qu, C. Wang, Q. Yuan, X. Li, and S. Qiu, Mater. Chem. Phys., 2009, 118, 273.

    Article  CAS  Google Scholar 

  99. A. Yamaguchi, M. Namekawa, T. Kamijo, T. Itoh, and N. Teramae, Anal. Chem., 2011, 83, 2939.

    Article  CAS  PubMed  Google Scholar 

  100. P. Yang, G. Wirnsberger, H. C. Huang, S. R. Cordero, M. D. McGehee, B. Scott, T. Deng, G. M. Whitesides, B. F. Chmelka, S. K. Buratto, and G. D. Stucky, Science, 2000, 287, 465.

    Article  CAS  PubMed  Google Scholar 

  101. G. Wirnsberger, P. Yang, B. J. Scott, B. F. Chmelka, and G. D. Stucky, Spectrochim. Acta, Part A, 2001, 57, 2049.

    Article  CAS  Google Scholar 

  102. I. Sokolov, Y. Y. Kievsky, and J. M. Kaszpurenko, Small, 2007, 3, 419.

    Article  CAS  PubMed  Google Scholar 

  103. R. Takeuchi, A. Shoji, and M. Sugawara, Sens. Actuators, B, 2013, 181, 29.

    Article  CAS  Google Scholar 

  104. T. Mogues, J. Li, and D. J. Kuter, J. Immunol. Methods, 2005, 300, 1.

    Article  CAS  PubMed  Google Scholar 

  105. L. J. Lucas, J. N. Chesler, and J.-Y. Yoon, Biosens. Bioelectron., 2007, 23, 675.

    Article  CAS  PubMed  Google Scholar 

  106. L. Stryer, “Biochemistry”, 4th ed., 1995, W. H. Freeman, New York.

  107. S. B. Lee, D. T. Mitchell, L. Trofin, T. K. Nevanen, H. Söderlund, and C. R. Martin, Science, 2002, 296, 2198.

    Article  CAS  PubMed  Google Scholar 

  108. R. E. Gyurcsányi, T. Vigassy, and E. Pretsch, Chem. Commun., 2003, 20, 2560.

    Article  Google Scholar 

  109. Z. Siwy, L. Trofin, P. Kohli, L. A. Baker, C. Trautmann, and C. R. Martin, J. Am. Chem. Soc., 2005, 127, 5000.

    Article  CAS  PubMed  Google Scholar 

  110. Y. Choi, L. A. Baker, H. Hillebrenner, and C. R. Martin, Phys. Chem. Chem. Phys., 2006, 8, 4976.

    Article  CAS  PubMed  Google Scholar 

  111. C. C. Harrell, Y. Choi, L. P. Horne, L. A. Baker, Z. S. Siwy, and C. R. Martin, Langmuir, 2006, 22, 10837.

    Article  CAS  PubMed  Google Scholar 

  112. S. M. Iqbal, D. Akin, and R. Bashir, Nat. Nanotechnol., 2007, 2, 243.

    Article  CAS  PubMed  Google Scholar 

  113. G. Jágerszki, R. E. Gyurcsányi, L. Höfler, and E. Pretsch, Nano Lett., 2007, 7, 1609.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  114. S. Ding, C. Gao, and L. Q. Gu, Anal. Chem., 2009, 81, 6649.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  115. R. Casasús, E. Aznar, M. D. Marcos, R. Martínez-Máñez, F. Sancenón, J. Soto, and P. Amorós, Angew. Chem., Int. Ed., 2006, 45, 6661.

    Article  CAS  Google Scholar 

  116. R. Casasús, E. Climent, M. D. Marcos, R. Martínez-Máñez, F. Sancenón, J. Soto, P. Amorós, J. Cano, and E. Ruiz, J. Am. Chem. Soc., 2008, 130, 1903.

    Article  PubMed  CAS  Google Scholar 

  117. M. Uto, E. K. Michaelis, I. F. Hu, Y. Umezawa, and T. Kuwana, Anal. Sci., 1990, 6, 221.

    Article  CAS  Google Scholar 

  118. H. Minami, M. Sugawara, K. Odashima, Y. Umezawa, M. Uto, E. K. Michaelis, and T. Kuwana, Anal. Chem., 1991, 63, 2787.

    Article  CAS  PubMed  Google Scholar 

  119. A. Hirano, M. Sugawara, Y. Umezawa, S. Uchino, and S. Nakajima-Iijima, Biosens. Bioelectron., 2000, 15, 173.

    Article  CAS  PubMed  Google Scholar 

  120. G. Favero, L. Campanella, S. Cavallo, A. D’Annibale, M. Perrella, E. Mattei, and T. Ferri, J. Am. Chem. Soc., 2005, 127, 8103.

    Article  CAS  PubMed  Google Scholar 

  121. R. J. White, E. N. Ervin, T. Yang, X. Chen, S. Daniel, P. S. Cremer, and H. S. White, J. Am. Chem. Soc., 2007, 129, 11766.

    Article  CAS  PubMed  Google Scholar 

  122. E. Neher and B. Sakmann, Nature, 1976, 260, 799.

    Article  CAS  PubMed  Google Scholar 

  123. B. Sakmann and E. Neher (eds.), “Single-Channel Recording”, 2nd ed., 1995, Plenum, New York.

  124. A. Hirano and M. Sugawara, Mini-Rev. Med. Chem., 2006, 6, 1091.

    Article  CAS  PubMed  Google Scholar 

  125. D. E. Bergles and C. E. Jahr, Neuron, 1997, 19, 1297.

    Article  CAS  PubMed  Google Scholar 

  126. J. S. Diamond, D. E. Bergles, and C. E. Jahr, Neuron, 1998, 21, 425.

    Article  CAS  PubMed  Google Scholar 

  127. C. Lüscher, R. C. Malenka, and R. A. Nicoll, Neuron, 1998, 21, 435.

    Article  PubMed  Google Scholar 

  128. D. E. Bergles, J. S. Diamond, and C. E. Jahr, Curr. Opin. Neurobiol., 1999, 9, 293.

    Article  CAS  PubMed  Google Scholar 

  129. T. Maeda, Y. Shimoshige, K. Mizukami, S. Shimohama, S. Kaneko, A. Akaike, and M. Satoh, Neuron, 1995, 15, 253.

    Article  CAS  PubMed  Google Scholar 

  130. M. Shimane, K. Miyagawa, and M. Sugawara, Anal. Biochem., 2006, 353, 83.

    Article  CAS  PubMed  Google Scholar 

  131. D. K. Patneau and M. L. Mayer, J. Neurosci., 1990, 10, 2385.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  132. T. Oka, Y. Tominaga, Y. Wakabayashi, A. Shoji, and M. Sugawara, Anal. Sci., 2009, 25, 353.

    Article  CAS  PubMed  Google Scholar 

  133. T. Maeda, S. Kaneko, A. Akaike, and M. Satoh, Neurosci. Lett., 1997, 224, 103.

    Article  CAS  PubMed  Google Scholar 

  134. D. J. Rossi, T. Oshima, and D. Attwell, Nature, 2000, 403, 316.

    Article  CAS  PubMed  Google Scholar 

  135. J. J. O’connor, J. Wu, M. J. Rowan, and R. Anwyl, Neuroscience, 1995, 69, 363.

    Article  PubMed  Google Scholar 

  136. N. Soma, N. Watanabe, A. Shoji, and M. Sugawara, Anal. Sci., 2013, 29, 181.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Chemistry, College of Humanities and Sciences, Nihon University, 156-8550, Sakurajyosui, Setagaya, Tokyo, Japan

    Masao Sugawaras & Misato Sakamoto

  2. School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, 192-0392, Hachioji, Tokyo, Japan

    Atsushi Shoji

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  1. Masao Sugawaras
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Correspondence to Masao Sugawaras.

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Sugawaras, M., Shoji, A. & Sakamoto, M. Pore-forming Compounds as Signal Transduction Elements for Highly Sensitive Biosensing. ANAL. SCI. 30, 119–128 (2014). https://doi.org/10.2116/analsci.30.119

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  • DOI: https://doi.org/10.2116/analsci.30.119

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