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Application of Terahertz Absorption Spectroscopy to Evaluation of Aging Variation of Medicine

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Abstract

The absorption spectra of three kinds of medicines both before and after the expiration date: Amlodin OD® (5 mg), Basen OD® (0.2 mg) and Gaster D® (10 mg) have been measured by terahertz time domain spectroscopy (THz-TDS). All the medicines show some differences in the THz absorption spectra between medicines before and after the expiration dates. X-Ray powder diffraction (XRD) studies of all medicines suggest that the polymorph of the main effective compound is not changed before and after the expiration date. Therefore, the differences in the THz spectra between medicines before and after the expiration dates arise from aging variation of diluting agents and/or from modifications of intermolecular interaction between the effective compounds and diluting agents.

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Authors and Affiliations

  1. Nagahama Institute of Bio-science and Technology, 1266 Tamura, Nagahama, Shiga, 526-0829, Japan

    Masaya Kawase

  2. Radioisotope Research Center, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka, 560-0043, Japan

    Masaya Kawase & Tadashi Saito

  3. Faculty of Pharmaceutical Sciences, Osaka Ohtani University, 3-11-1 Nishikiorikita, Tondabayashi, Osaka, 584-8540, Japan

    Masafumi Ogawa, Hideki Uejima, Yasutoshi Hatsuda, Sonoyo Kawanishi, Yoshihiko Hirotani, Michiaki Myotoku, Kenji Ikeda, Hiroki Konishi & Ikumi Iga

  4. Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Kita, Okayama, 700-8530, Japan

    Junji Yamakawa

  5. Advanced Infrared Spectroscopy, 3-17-16 Sennin, Hachioji, Tokyo, 193-0835, Japan

    Seizi Nishizawa

  6. Research Center for Development of Far-Infrared Region, University of Fukui, 3-9-1 Bunkyo, Fukui, 901-8507, Japan

    Kohji Yamamoto & Masahiko Tani

Authors
  1. Masaya Kawase
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  2. Tadashi Saito
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  3. Masafumi Ogawa
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  4. Hideki Uejima
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  5. Yasutoshi Hatsuda
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  6. Sonoyo Kawanishi
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  7. Yoshihiko Hirotani
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  8. Michiaki Myotoku
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  9. Kenji Ikeda
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  10. Hiroki Konishi
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  11. Ikumi Iga
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  12. Junji Yamakawa
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  13. Seizi Nishizawa
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  14. Kohji Yamamoto
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  15. Masahiko Tani
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Corresponding author

Correspondence to Masaya Kawase.

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Kawase, M., Saito, T., Ogawa, M. et al. Application of Terahertz Absorption Spectroscopy to Evaluation of Aging Variation of Medicine. ANAL. SCI. 27, 209–212 (2011). https://doi.org/10.2116/analsci.27.209

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  • DOI: https://doi.org/10.2116/analsci.27.209

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