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Flow-Injection Spectrophotometric Determination of Novalgin in Pharmaceuticals Using Micellar Medium

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Abstract

A sensitive flow-injection (FI) procedure with spectrophotometric detection in a micellar medium is proposed for the determination of novalgin. The method is based on the instantaneous formation of a red-orange product (λmax = 510 nm) after the reaction between novalgin and p-dimethylaminocinnamaldehyde (p-DAC) in a dilute acid medium. The sensitivity of this reaction was increased by a factor of 5.6 in the presence of sodium dodecyl sulfate (SDS). Experimental design methodologies were used to optimize the chemical and FI variables. The calibration curve was linear in the range of 1.45 × 10-6 to 2.90 × 10-5 mol L-1 with an excellent correlation coefficient (r = 0.9999). The detection limit was 1.31 × 10-7 mol L-1 (n = 20, RSD = 2.0%). No interferences were observed from the common excipients. The results obtained by the proposed method were favorably compared with those given by the iodometric reference method at 95% confidence level.

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References

  1. “Martindale the Extra Pharmacopoeia: Evaluated Information on the World’s Drugs and Medicines”, ed. J. E. F. Reynolds, 31st ed., 1996, The Royal Pharmaceutical Society, London, 39.

    Google Scholar 

  2. H. Ergun, D. A. C. Frattarelli, and J. V. Aranda, J. Pharm. Biomed. Anal., 2004, 35, 479.

    Article  CAS  Google Scholar 

  3. J. S. Albuquerque, V. L. Silva, F. Lima, A. N. Araújo, and M. C. B. S. M. Montenegro, Anal. Sci., 2003, 19, 691.

    Article  CAS  Google Scholar 

  4. M. K. Srivastava, S. Ahmad, D. Singh, and I. S. Shukla, Analyst, 1985, 110, 735.

    Article  CAS  Google Scholar 

  5. European Pharmacopoeia, Council of Europe, 2005, v.2, France, 2002.

    Google Scholar 

  6. M. C. Inandar and N. M. Sanghavi, Indian J. Pharm., 1971, 33, 94.

    Google Scholar 

  7. N. H. Eddine, F. Bressolle, B. Mandrou, and H. Fabre, Analyst, 1982, 107, 67.

    Article  CAS  Google Scholar 

  8. G. B. Golubitskii, E. V. Budko, and V. M. Ivanov, J. Anal. Chem., 2006, 61, 67.

    Article  CAS  Google Scholar 

  9. I. Baranowska, P. Markowski, and J. Baranowski, Anal. Chim. Acta, 2006, 570, 46.

    Article  CAS  Google Scholar 

  10. M. F. S. Teixeira, L. H. Marcolino, O. Fatibello-Filho, E. R. Dockal, and E. T. G. Cavalheiro, J. Braz. Chem. Soc., 2004, 15, 803.

    Article  CAS  Google Scholar 

  11. F. Belal, Electroanalysis, 1992, 4, 589.

    Article  CAS  Google Scholar 

  12. O. A. Zaprorozhtes, E. A. Krushinskaya, N. A. Lipkovskaya, and V. V. Sukhan, J. Anal. Chem., 2001, 56, 524.

    Article  Google Scholar 

  13. N. Erk and F. Onur, Anal. Lett., 1997, 30, 1201.

    Article  CAS  Google Scholar 

  14. N. Acar and F. Onur, Anal. Lett., 1996, 29, 763.

    Article  CAS  Google Scholar 

  15. K. A. Sakiara, L. Pezza, C. B. Melios, H. R. Pezza, and M. De Moraes, Farmaco, 1999, 54, 629.

    Article  CAS  Google Scholar 

  16. S. Z. Qureshi, A. Saeed, and S. Haque, Michrochem. J., 1990, 41, 362.

    Article  CAS  Google Scholar 

  17. S. Z. Qureshi, A. Saeed, and J. Hassan, Talanta, 1989, 36, 869.

    Article  CAS  Google Scholar 

  18. B. Moreli, J. Pharm. Biomed. Anal., 2003, 33, 423.

    Article  Google Scholar 

  19. M. S. Garcia, M. J. Albero, C. Sanchez-Pedreno, and M. S. Abuherba, Eur. J. Pharm. Biopharm., 2005, 61, 87.

    Article  Google Scholar 

  20. E. P. Medeiros, S. Castro, F. M. Formiga, S. R. B. Santos, M. C. U. Araújo, and V. B. Nascimento, Michrochem. J., 2004, 78, 91.

    Article  CAS  Google Scholar 

  21. L. H. Marcolino-Jr., V. G. Bonifácio, O. Fatibello-Filho, and M. F. S. Teixeira, Quim. Nova, 2005, 28, 783.

    Article  Google Scholar 

  22. J. S. Albuquerque, V. L. Silva, F. Lima, A. N. Araújo, and M. C. B. S. M. Montenegro, Anal. Sci., 2003, 19, 691.

    Article  CAS  Google Scholar 

  23. Y. M. Huang, C. Zhang, X. R. Zhang, and Z. J. Zhang, Fresenius J. Anal. Chem., 1999, 365, 381.

    Article  CAS  Google Scholar 

  24. T. Perez-Ruiz, C. Martinez-Lozano, V. Tomás, and J. Carpena, Microchem. J., 1993, 47, 296.

    Article  CAS  Google Scholar 

  25. A. V. Pereira, L. Penckowski, M. Vosgerau, M. F. Sassá, and O. Fatibello-Filho, Quim. Nova, 2002, 25, 553.

    Article  CAS  Google Scholar 

  26. J. L. F. C. Lima, S. M. O. Sá, J. L. M. Santos, and E. A. G. Zagatto, J. Pharm. Biomed. Anal., 2003, 32, 1011.

    Article  CAS  Google Scholar 

  27. J. S. Esteve-Romero, E. F. Simó-Alfonso, M. C. Garcia-Alvarez-Coque, and G. Ramis-Ramos, Trends Anal. Chem., 1995, 14, 29.

    Article  CAS  Google Scholar 

  28. C. A. Georgiou, M. A. Koupparis, and T. P. Hadjiioannou, Talanta, 1991, 38, 689.

    Article  CAS  Google Scholar 

  29. F. R. P. Rocha, J. A. Nobrega, and O. Fatibello-Filho, Green Chemistry, 2001, 3, 216.

    Article  CAS  Google Scholar 

  30. H. Fabre, N. H. Eddine, F. Bressolle, and B. Mondrou, Analyst, 1982, 107, 61.

    Article  CAS  Google Scholar 

  31. S. Ono, R. Onishi, and K. Kawahara, Yakugaku Zasshi, 1966, 86, 11.

    Article  CAS  Google Scholar 

  32. N. H. Zawilla, A. A. Mohammad, N. M. El Kousy, and S. M. El-Moghazy Aly, J. Pharm. Biomed. Anal., 2002, 27, 243.

    Article  CAS  Google Scholar 

  33. A. A. El-Sherif, M. I. Walash, M. F. El-Tarras, and A. O. Osman, Anal. Lett., 1997, 30, 1881.

    Article  Google Scholar 

  34. M. A. Gotardo, A. C. Gigante, L. Pezza, H. R. Pezza, Talanta, 2004, 64, 361.

    Article  CAS  Google Scholar 

  35. S. Y. Doronin, R. K. Chernova, and N. N. Gusakova, Russ. J. Gen. Chem., 2005, 75, 261.

    Article  CAS  Google Scholar 

  36. A. K. Yatziirsky, N. T. Yatzimirsky, and S. Krinova, Anal. Chem., 1994, 66, 2232.

    Article  Google Scholar 

  37. J. S. Esteve-Romero, L. M. Pons, M. C. Garcia-Alvarez-Coque, and G. Ramis-Ramos, Anal. Lett., 1994, 27, 1557.

    Article  CAS  Google Scholar 

  38. M. Thompson, S. L. R. Ellison, and R. Wood, Pure Appl. Chem., 2002, 74, 835.

    Article  CAS  Google Scholar 

  39. J. C. Miller and J. N. Miller, “Statistics for Analytical Chemistry”, 2nd ed., 1992, Ellis Horwood, London, 55.

    Google Scholar 

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Authors and Affiliations

  1. Instituto de Química-UNESP, P. O. Box 355, CEP, 14801-970, Araraquara, S P, Brazil

    Patrícia Los Weinert, Leonardo Pezza & Helena Redigolo Pezza

  2. Departamento de Química-FC/UNESP, 17033-360, Bauru, SP, Brazil

    João Roberto Fernandes

Authors
  1. Patrícia Los Weinert
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  2. João Roberto Fernandes
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  3. Leonardo Pezza
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  4. Helena Redigolo Pezza
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Correspondence to Helena Redigolo Pezza.

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Weinert, P.L., Fernandes, J.R., Pezza, L. et al. Flow-Injection Spectrophotometric Determination of Novalgin in Pharmaceuticals Using Micellar Medium. ANAL. SCI. 23, 1383–1389 (2007). https://doi.org/10.2116/analsci.23.1383

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  • DOI: https://doi.org/10.2116/analsci.23.1383

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