概要
目的
探讨人类端粒酶逆转录酶 (h-TERT) 和 Ki-67 与子宫内膜异位症复发的相关性.
创新点
第一次将 h-TERT 和 Ki-67 联合表达水平可作为卵巢子宫内膜异位症复发的有用预测标志物.
方法
收集 30 例术后 30 个月复发的卵巢子宫内膜异位症患者、 30 例术后 30 个月未复发的卵巢子宫内膜异位症患者和 30 例对照组的子宫内膜异位症组织样本. 采用免疫组织化学方法检测异位子宫内膜组织中 h-TERT 和 Ki-67 的表达.
结论
h-TERT 和 Ki-67 联合表达水平可作为卵巢子宫内膜异位症复发的有用预测标志物, 子宫内膜 h-TERT 过度表达以及术后血清 CA125 水平升高可能在卵巢子宫内膜异位症复发中起重要作用.
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Acknowledgments
This work was supported by the Natural Science Foundation of Zhejiang Province (No. LGF20H040009), China.
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Jie LUO, Jun LIN, and Jianhong ZHOU conceived the study, participated in its design and coordination, and helped to draft the manuscript. Zhimin SONG carried out the immunohistochemistry studies and drafted the manuscript. Tao ZHANG and Ketan CHU were involved in clinical data collection and data analysis, and Jingyi LI was involved in revising the manuscript. All authors have read and approved the final manuscript, and therefore, take responsibility for the integrity of the study.
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Jie LUO, Zhimin SONG, Tao ZHANG, Ketan CHU, Jingyi LI, Jianhong ZHOU, and Jun LIN declared that they have no conflict of interests.
The study was approved by the Human Ethics Committee of Women’s Hospital, Zhejiang University School of Medicine (No. 20190014), China. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5). Informed consent was obtained from all patients for being included in the study. Additional informed consent was obtained from all patients for whom identifying information is included in this article.
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Luo, J., Song, Z., Zhang, T. et al. Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis. J. Zhejiang Univ. Sci. B 23, 158–163 (2022). https://doi.org/10.1631/jzus.B2100502
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DOI: https://doi.org/10.1631/jzus.B2100502