Abstract
Basophils, which are considered as redundant relatives of mast cells and the rarest granulocytes in peripheral circulation, have been neglected by researchers in the past decades. Previous studies have revealed their vital roles in allergic diseases and parasitic infections. Intriguingly, recent studies even reported that basophils might be associated with cancer development, as activated basophils synthesize and release a variety of cytokines and chemokines in response to cancers. However, it is still subject to debate whether basophils function as tumor-protecting or tumor-promoting components; the answer may depend on the tumor biology and the microenvironment. Herein, we reviewed the role of basophils in cancers, and highlighted some potential and promising therapeutic strategies.
概要
嗜碱性粒细胞是外周血中比例最少的粒细胞, 曾一度被认为是肥大细胞的“冗余亲属”, 在过去的几十年里一直被研究人员忽视. 以往的研究揭示了其在过敏性疾病和寄生虫感染中的重要作用, 最新研究则表明嗜碱性粒细胞可能与肿瘤的发生发展同样具有密切关联. 活化的嗜碱性粒细胞合成并释放多种细胞因子和趋化因子参与并调控肿瘤的发生发展. 然而, 嗜碱性粒细胞究竟扮演着抑癌还是促癌的角色至今仍存在较大争议, 这可能取决于肿瘤生物学行为以及微环境的影响. 因此, 我们回顾了嗜碱性粒细胞的生物学功能及其在肿瘤发生发展中的潜在作用, 并展望其在肿瘤治疗中的应用前景.
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Acknowledgments
This work was supported by the Shanghai Sailing Program (No. 21YF1407100), the China Postdoctoral Science Foundation (No. 2021M690037), the National Natural Science Foundation of China (Nos. 82103409 and 81773068), and the National Key R&D Program of China (No. 2019YFC1315902).
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Jicheng ZHANG, Ning PU, and Wenchuan WU came up with the idea of the manuscript. Jicheng ZHANG, Hanlin YIN, Qiangda CHEN, and Guochao ZHAO wrote the manuscript. Ning PU, Wenhui LOU, and Wenchuan WU revised the manuscript. All authors have read and approved the final manuscript, and therefore, take responsibility for the integrity of the study.
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Jicheng ZHANG, Hanlin YIN, Qiangda CHEN, Guochao ZHAO, Wenhui LOU, Wenchuan WU, and Ning PU declare that they have no conflicts of interests.
This article does not contain any studies with human or animal subjects performed by any of the authors.
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Zhang, J., Yin, H., Chen, Q. et al. Basophils as a potential therapeutic target in cancer. J. Zhejiang Univ. Sci. B 22, 971–984 (2021). https://doi.org/10.1631/jzus.B2100110
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DOI: https://doi.org/10.1631/jzus.B2100110