Emerging relationship between RNA helicases and autophagy

Abstract

RNA helicases, the largest family of proteins that participate in RNA metabolism, stabilize the intracellular environment through various processes, such as translation and pre-RNA splicing. These proteins are also involved in some diseases, such as cancers and viral diseases. Autophagy, a self-digestive and cytoprotective trafficking process in which superfluous organelles and cellular garbage are degraded to stabilize the internal environment or maintain basic cellular survival, is associated with human diseases. Interestingly, similar to autophagy, RNA helicases play important roles in maintaining cellular homeostasis and are related to many types of diseases. According to recent studies, RNA helicases are closely related to autophagy, participate in regulating autophagy, or serve as a bridge between autophagy and other cellular activities that widely regulate some pathophysiological processes or the development and progression of diseases. Here, we summarize the most recent studies to understand how RNA helicases function as regulatory proteins and determine their association with autophagy in various diseases.

摘要

RNA 解旋酶是参与RNA 代谢的最大的蛋白质家 族, 通过翻译和前体RNA 剪接等各种过程来稳 定细胞内环境。这些蛋白质还与一些疾病有关, 如癌症和病毒性疾病。自噬是一种自我消化和保 护细胞的运输过程, 通过降解多余的细胞器和细 胞垃圾来稳定内部环境或维持细胞的基本生存, 与人类疾病有关。与自噬相似, RNA 解旋酶在维 持细胞内稳态中发挥着重要的作用, 与多种疾病 相关。近年来的研究表明, RNA 解旋酶与自噬密 切相关, 参与调节自噬或作为自噬与其他细胞活 动之间的桥梁, 广泛影响了一些病理生理过程。 本文总结了最新的研究, 以了解RNA 解旋酶调 节自噬的机制以及这些机制与疾病之间的联系。