Abstract
Before a breeder invests selection pressure on a trait of interest, it needs to be established whether that trait is actually heritable. Some traits may not have been measured widely in pedigreed populations, for example, a discase or deformity may become more prevalent than previously, but is still relatively rare. One approach to detect inheritance would be to screen a commercial population to obtain a sample of “affecteds” (the test group) and to also obtain a random control group. These individuals are then genotyped with a set of genetic markers and the relationships between individuals within each group estimated. If the relatedness is higher in the test group than in the control group, this provides initial evidence for the trait being heritable. A power simulation shows that this approach is feasible with moderate resources.
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Ayres, K.L., Overall, A.D.J., 2004. Api-calc 1.0: a computer program for calculating the average probability of identity allowing for substructure, inbreeding and the presence of close relatives. Molecular Ecology Notes, 4(2):315–318. [doi:10.1111/j.1471-8286.2004.00616.x]
Balding, D.J., 2006. A tutorial on statistical methods for population association studies. Nature Reviews Genetics, 7(10):781–791. [doi:10.1038/nrg1916]
Blouin, M.S., 2003. DNA-based methods for pedigree reconstruction and kinship analysis in natural populations. Trends in Ecology and Evolution, 18(10):503–511. [doi:10.1016/S0169-5347(03)00225-8]
Coltman, D.W., 2005. Testing marker-based estimates of heritability in the wild. Molecular Ecology, 14(8):2593–2599. [doi:10.1111/j.1365-294X.2005.02600.x]
Manly, B.F.J., 1997. Randomization, Bootstrap and Monte Carlo Methods in Biology. Chapman & Hall, London, p. 1–23.
Milligan, B.G., 2003. Maximum-likelihood estimation of relatedness. Genetics, 163(3):1153–1167.
Oliehoek, P.A., Windig, J.J., van Arendonk, J.A.M., Bijma, P., 2006. Estimating relatedness between individuals in general populations with a focus on their use in conservation programs. Genetics, 173(1):483–496. [doi:10.1534/genetics.105.049940]
Queller, D.C., Goodnight, K.F., 1989. Estimating relatedness using genetic markers. Evolution, 43(2):258–275. [doi:10.2307/2409206]
Taberlet, P., Luikart, G., 1999. Non-invasive genetic sampling and individual identification. Biological Journal of the Linnean Society, 68(1–2):41–55. [doi:10.1006/bijl.1999.0329]
Thomas, S.C., 2005. The estimation of genetic relationships using molecular markers and their efficiency in estimating heritability in natural populations. Philosophical Transactions of the Royal Society B: Biological Sciences, 360(1459):1457–1467. [doi:10.1098/rstb.2005.1675]
Thomas, S.C., Hill, W.G., 2002. Sibship reconstruction in hierarchical population structures using Markov chain Monte Carlo techniques. Genetical Research, 79(3): 227–234. [doi:10.1017/S0016672302005669]
van de Casteele, T., Galbusera, P., Matthysen, E., 2001. A comparison of microsatellite-based pairwise relatedness estimators. Molecular Ecology, 10(6): 1539–1549. [doi:10.1046/j.1365-294X.2001.01288.x]
Wang, J., 2002. An estimator for pariwise relatedness using molecular markers. Genetics, 160(3):1203–1215.
Weir, B.S., Anderson, A.D., Hepler, A.B., 2006. Genetic relatedness analysis: modern data and new challenges. Nature Reviews Genetics, 7(10):771–780. [doi:10.1038/nrg1960]
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Dodds, K.G., Amer, P.R. & Auvray, B. Using genetic markers in unpedigreed populations to detect a heritable trait. J. Zhejiang Univ. - Sci. B 8, 782–786 (2007). https://doi.org/10.1631/jzus.2007.B0782
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DOI: https://doi.org/10.1631/jzus.2007.B0782