Abstract
Objective
Microcapsule chemoembolism is a promising treatment of tumors. We describe a deep lingual arterial embolization of tongue carcinoma with microcapsuled carboplatinum.
Methods
Lingual artery cast specimens from cadavers were microscopically examined, and 78 patients with tongue cancer were recruited and treated with the deep lingual arterial embolization therapy.
Results
Microcapsule embolism occurred approximately at the fifth or sixth level of the deep lingual artery branches. The five-year survival rate was 88.5% (69 out of 78), and the ten-year survival rate 52.6% (41 out of 78).
Conclusion
The deep lingual arterial embolization of tongue carcinoma with microcapsuled carboplatinum is an effective therapy to treat carcinoma in mid-margin or mid-body of the tongue.
Similar content being viewed by others
References
Diaco, D.S., Hajarizadeh, H., Mueller, C.R., Fletcher, W.S., Pommier, R.F., Woltering, E.A., 1995. Treatment of metastatic carcinoid tumors using multimodality therapy of octreotide acetate, intra-arterial chemotherapy, and hepatic arterial chemoembolization. Am. J. Surg., 169(5):523–528. [doi:10.1016/S0002-9610(99)80210-4]
Dockery, P., Fraher, J., 2007. The quantification of vascular beds: a stereological approach. Exp. Mol. Pathol., 82(2):110–120. [doi:10.1016/j.yexmp.2006.12.011]
Esteban, J.M., Gil, J., 2002. Therapeutic effect of chemoembolization therapy on hepatocellular carcinoma: evaluation with contrast-enhanced power Doppler sonography and contrast-enhanced harmonic imaging. Acad. Radiol., 9(2):s382–s383. [doi:10.1016/S1076-6332(03)80238-6]
Gu, G.H., Huang, J.Q., He, H., 2002. Sequential-release of anticancer drugs microcapsulated with ethylcellulose. Chin. Med. J., 115(11):1730–1732.
Harris, M., Gibbs, P., Cebon, J., Jones, R., Sewell, R., Schelleman, T., Angus, P., 2001. Hepatocellular carcinoma and chemoembolization. Intern. Med. J., 31(9):517–522. [doi:10.1046/j.1445-5994.2001.00131.x]
Hayashi, P.H., Ludkowski, M., Forman, L.M., Osgood, M., Johnson, S., Kugelmas, M., 2004. Hepatic artery chemoembolization for hepatocellular carcinoma in patients listed for liver transplantation. Am. J. Transplant., 4(5):782–787. [doi:10.1111/j.1600-6143.2004.00413.x]
Huang, Y.H., Wu, J.C., Chen, S.C., Chen, C.H., Chang, J.H., Huo, T.I., 2006. Survival benefit of transcatheter arterial chemoembolizaton in patients with hepatocellular carcinoma larger than 10 cm in diameter. Aliment. Pharmacol. Ther., 23(1):129–135. [doi:10.1111/j.1365-2036.2006.02704.x]
Iguchi, H., Kusuki, M., Nakamura, A., Kanazawa, A., Hachiya, K., Yamane, H., 2006. Outcome of preoperative concurrent chemoradiotherapy and surgery for resectable lingual squamous cell carcinoma greater than 3 cm: the possibility of less extensive surgery. Oral Oncol., 42(4):391–397. [doi:10.1016/j.oraloncology.2005.09.006]
Jang, M.K., Lee, H.C., Kim, I.S., Lim, Y.S., Chung, Y.H.W.A., Lee, Y.S., 2004. Role of additional angiography and chemoembolization in patients with hepatocellular carcinoma who achieved complete necrosis following transarterial chemoembolization. J. Gastroenterol. Hepatol., 19(9):1074–1080. [doi:10.1111/j.1440-1746.2004.03414.x]
Kato, T., Nemoto, R., Mori, H., Takahashi, M., Harada, M., 1981. Arterial chemoembolization with mitomycin C microcapsules in the treatment of primary or secondary carcinoma of the kidney, liver, bone and intrapelvic organs. Cancer, 48(3):674–680. [doi:10.1002/1097-0142(19810801)48:3〈674::AID-CNCR2820480303〉3.0.CO;2-E]
Kimura, Y., Ariji, Y., Gotoh, M., Toyoda, T., Kato, M., Kawamata, A., 2001. Doppler sonography of the deep lingual artery. Acta Radiol., 42(3):306–311. [doi:10.1080/028418501127346693]
Kovács, A.F., Turowski, B., 2002. Chemoembolization of oral and oropharyngeal cancer using a high-dose cisplatin crystal suspension and degradable starch microspheres. Oral Oncol., 38(1):87–95. [doi:10.1016/S1368-8375(01)00088-4]
Munro, N.P., Woodhams, S., Nawrocki, J.D., Fletcher, M.S., Thomas, P.J., 2003. The role of transarterial embolization in the treatment of renal cell carcinoma. BJU Int., 92(3):240. [doi:10.1046/j.1464-410X.2003.04314.x]
Ross, C.J.D., Chang, P.L., 2002. Development of small alginate microcapsules for recombinant gene product delivery to the rodent brain. J. Biomater. Sci. Polym. Ed., 13(8):953–962. [doi:10.1163/156856202320401988]
Ruben, R.P., Tim, O.L., Murat, B., Corrina, C.M.M., Timm, K., Michael, G., 2005. Prospective analysis of German patients with hepatocellular carcinoma undergoing transcatheter arterial chemoembolization with or without prophylactic antibiotic therapy. J. Gastroenterol. Hepatol., 20(7):1134.
Shang, Z.J., Li, Z.B., Li, J.R., 2006. VEGF is up-regulated by hypoxic stimulation and related to tumour angiogenesis and severity of disease in oral squamous cell carcinoma: in vitro and in vivo studies. Int. J. Oral Maxillofac. Surg., 35(6):533–538. [doi:10.1016/j.ijom.2005.09.006]
Sun, C.X., Yang, M.D., Huang, J.Q., Zhang, M., 1997. The scanning electronic microscope study of human lingual artery cast model. Chin. J. Stomatol., 32(3):190 (in Chinese).
Tsurumaru, D., Kuroiwa, T., Yabuuchi, H., Hirata, H., Higaki, Y., Tomita, K., 2007. Efficacy of intra-arterial infusion chemotherapy for head and neck cancers using coaxial catheter technique: initial experience. Cardiovasc. Intervent. Radiol., 30(2):207–211. [doi:10.1007/s00270-005-0272-0]
Uehara, M., Sano, K., Ikeda, H., Sekine, J., Irie, A., Toyota, T., 2004. Expression of vascular endothelial growth factor and prognosis of oral squamous cell carcinoma. Oral Oncol., 40(3):321–325. [doi:10.1016/j.oraloncology.2003.08.020]
Uraki, J., Yamakado, K., Nakatsuka, A., Takeda, K., 2004. Transcatheter hepatic arterial chemoembolization for hepatocellular carcinoma invading the portal veins: therapeutic effects and prognostic factors. Eur. J. Radiol., 51(1):12–18. [doi:10.1016/S0720-048X(03)00219-5]
Veness, M.J., 1999. Tongue cancer in younger patients. Aust. Radiol., 43(1):76–82. [doi:10.1046/j.1440-1673.1999.00606.x]
Veness, M.J., Morgan, G.J., Sathiyaseelan, Y., Gebski, V., 2003. Anterior tongue cancer: age is not a predictor of outcome and should not alter treatment. ANZ J. Surg., 73(11):899–905. [doi:10.1046/j.1445-2197.2003.02818.x]
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
He, H., Huang, Jq., Ping, Fy. et al. Deep lingual arterial chemoembolization of tongue carcinoma with microcapsuled anticancer drug. J. Zhejiang Univ. - Sci. B 8, 704–708 (2007). https://doi.org/10.1631/jzus.2007.B0704
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1631/jzus.2007.B0704
Key words
- Tongue carcinoma
- Artery cast
- Arterial chemoembolization
- Deep lingual arterial embolization
- Anticancer drug
- Carboplatinum