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Superselective intra-arterial chemoradiotherapy using altered blood flow compared to conventional systemic chemoradiotherapy for locally advanced oral squamous cell carcinoma: a single-center retrospective study

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A Correction to this article was published on 09 March 2021

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Abstract

Purpose

To evaluate the efficacy and safety of superselective intra-arterial (IA) chemoradiotherapy with cisplatin and transcatheter arterial embolization (TAE) on advanced oral cancer, and to compare it with that of systemic chemoradiotherapy.

Materials and methods

This single-center retrospective study included 23 consecutive patients with locally advanced oral squamous cell carcinoma from November 2011 to November 2019. Of these, 15 received superselective IA cisplatin chemoradiotherapy with altered blood flow in the branches of the external carotid artery, and eight received systemic chemoradiotherapy. Medical charts were reviewed for the evaluation of patient data, drug toxicity, and antitumor efficacy.

Results

Local control rate for the superselective IA infusion group, who underwent 6–7 cycles was significantly higher than that of the systemic chemotherapy group (11/13, 85% vs 3/8, 38%; p = 0.04). Regional control, locoregional control, disease-free survival, and overall survival rates were not significantly different between the groups (p = 0.15–0.907). Acute toxicity rates of grade 3 or higher were not significantly different between the IA and IV chemotherapy groups (p = 0.221).

Conclusion

Superselective IA chemoradiotherapy with cisplatin using altered blood flow in the branches of the external carotid artery with TAE may be useful for inoperable oral cancer.

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Authors and Affiliations

  1. Department of Radiology, Tokyo Dental College Ichikawa General Hospital, 5-11-13, Sugano, Ichiwaka, Chiba, 272-8513, Japan

    Koichi Masuda, Shinji Yamazoe & Takuji Mogami

  2. Department of Radiology, The Jikei Medical University Hosipital, 3-25-8, Nishishinbashi, Minato-ku, Tokyo, 105-8461, Japan

    Akira Baba & Hiroya Ojiri

  3. Oral Cancer Center, Tokyo Dental College Ichikawa General Hospital, 5-11-13, Sugano, Ichiwaka, Chiba, 272-8513, Japan

    Satoru Ogane & Takeshi Nomura

Authors
  1. Koichi Masuda
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  2. Shinji Yamazoe
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  3. Akira Baba
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  4. Takuji Mogami
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  5. Satoru Ogane
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  6. Takeshi Nomura
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  7. Hiroya Ojiri
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Correspondence to Koichi Masuda.

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The authors declare no conflicts of interest associated with this manuscript.

Ethical approval

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5). Informed consent was obtained from all patients for being included in the study.'

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The original online version of this article was revised due to a retrospective Open Access cancellation.

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Masuda, K., Yamazoe, S., Baba, A. et al. Superselective intra-arterial chemoradiotherapy using altered blood flow compared to conventional systemic chemoradiotherapy for locally advanced oral squamous cell carcinoma: a single-center retrospective study. Oral Radiol 37, 700–706 (2021). https://doi.org/10.1007/s11282-021-00519-5

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  • DOI: https://doi.org/10.1007/s11282-021-00519-5

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