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Expression of matrix metalloproteinase-9 in nasopharyngeal carcinoma and association with Epstein-Barr virus infection

  • Biomedical Science
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Abstract

Objective: To evaluate the expression of matrix metalloproteinase-9 (MMP9) in nasopharyngeal carcinoma and the association between MMP9 and Epstein-Barr virus infection. Methods: The MMP9 expression was studied by immunohistochemical analysis; and Epstein-Barr virus encoded small nuclear mRNA-1 (EBER-1) produced by in situ hybridization were examined in 41 nasopharyngeal carcinoma sections, and the relation between them, and the associations of MMP9 with clinical features were statistically analyzed. Results: Positive expression rate of MMP9 was 73.17%. The expression of MMP9 showed significant positive correlation with the expression of EBER-1 (γ=0.483, P=0.001). There was significant association of MMP9 expression with lymph nodes metastasis and clinical stage (P<0.001), non-significant association with age, gender, pathological classification and T classification. Conclusions: The highly pronounced expression of MMP9 is associated with cervical lymph nodes metastasis. Epstein-Barr virus can enhance NPC metastasis by up-regulating the expression of MMP9.

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  1. Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 310016, Hangzhou, China

    Jian-guo Tang, Xuan Li & Ping Chen

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  1. Jian-guo Tang
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  2. Xuan Li
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  3. Ping Chen
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Correspondence to Jian-guo Tang.

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Tang, Jg., Li, X. & Chen, P. Expression of matrix metalloproteinase-9 in nasopharyngeal carcinoma and association with Epstein-Barr virus infection. J. Zheijang Univ.-Sci. 5, 1304–1312 (2004). https://doi.org/10.1631/jzus.2004.1304

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  • DOI: https://doi.org/10.1631/jzus.2004.1304

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